Purified anti-human CD235a (Glycophorin A) Recombinant Antibody

Pricing & Availability
Clone
QA19A08 (See other available formats)
Regulatory Status
RUO
Other Names
PAS-2, Sialoglycoprotein alpha, MN sialoglycoprotein, Glycophorin A, MNS blood group, GYPA
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
QA19A08_PURE_CD235a_Antibody_062922
Human red blood cells were stained with purified anti-human CD235a (Glycophorin A) recombinant (clone QA19A08) (filled histogram) or mouse IgG2a, κ isotype control (open histogram) followed by PE anti-mouse IgG.
  • QA19A08_PURE_CD235a_Antibody_062922
    Human red blood cells were stained with purified anti-human CD235a (Glycophorin A) recombinant (clone QA19A08) (filled histogram) or mouse IgG2a, κ isotype control (open histogram) followed by PE anti-mouse IgG.
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379002 100 µg £70
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Description

CD235a (Glycophorin A) is member of the glycophorin A family. It is a type I sialoglycoprotein with a molecular weight of 10 kD, present in the cell membrane as a homodimer. Glycophorin A is expressed by erythroid precursors and erythrocytes. It carries the antigen determinants for the MNS blood groups and has been proposed to be an inhibitor of hemagglutination and hemolysis. Glycophorin A binds siglec 5, the erythrocyte binding antigen (EBA-175) of P. falciparum and some viruses, including influenza virus and hepatitis A virus.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2927846 (BioLegend Cat. No. 379002)

Antigen Details

Structure
Member of the glycophorin A family; type I protein with a molecular weight of 10 kD; present in the membrane as homodimer
Distribution

Erythrocytes and erythroid precursors

Function
Possible inhibitor of hemagglutination and hemolysis; carries the antigen determinants for the MNS blood groups
Ligand/Receptor
Siglec 5, erythrocyte binding antigen (EBA-175) of P. falciparum, receptor for the influenza virus, hepatitis A virus
Antigen References
  1. Reid ME. 2009. Immunohematology. 25:95-101.
  2. Palacajornsuk P. 2006. Immunohematology. 22:171-82.
  3. Pasvol G. 2003. Trends Parasitol. 19:430-2.
  4. Takakuwa Y. 2001. Curr Opin Hematol. 8:80-4.
Gene ID
2993 View all products for this Gene ID
UniProt
View information about CD235a on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 06/29/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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