- W18073A (See other available formats)
- Other Names
- GSN, Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin
- Rat IgG2a, κ
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- Product Citations
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Gelsolin (GSN) is a calcium-regulated protein that serves actin filament assembly and disassembly and regulates cytoskeletal actin organization. GSN caps the plus end of the actin-filament to block monomer exchange, consequently, regulating filament length near the plasma membrane. Further, it contributes to cell movement and cell morphology. Four different isoforms of the molecule have been described that are produce via alternative splicing and initiation, including a soluble form. GSN is associated with a variety of diseases such as inflammation, cancer and amyloidosis.Product Details
- Antibody Type
- Host Species
- Partial human recombinant Gelsolin protein (amino acids 239-503)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IP - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 1.0 µg per ml. For immunoprecipitation, the suggested use of this reagent is 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- GSN is a 782 amino acid protein with a predicted molecular weight of 86 kD
- Functions in assembly and disassembly of actin filaments.
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure
- Molecular Family
- Protein Kinases/Phosphatase
- Antigen References
- Janmey, P.A. and Stossel, T.P., 1987. Nature. 325:362
- Burtnick LD, et al. 1997. Cell. 90:661.
- Gene ID
- 2934 View all products for this Gene ID
- View information about Gelsolin on UniProt.org
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