- A17160B (See other available formats)
- Other Names
- LGALS2, HL14, Lectin, CGL-2, Galactoside-Binding, Soluble, 2 Beta-Galactoside-Binding Lectin L-14-II, Lactose-Binding Lectin 2, S-Lac Lectin 2, Gal-2
- Mouse IgG2b, κ
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- Product Citations
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Human Galectin-2 (Gal-2) is a soluble lactose-binding lectin that was initially cloned from a human hepatoma cDNA library, and designated as L-14-II (LGALS2). The galectins are a family of lectins that possess similar carbohydrate binding specificities and conserved consensus sequences. The mammalian galectins are involved in the regulation of inflammation, cell adhesion, cell proliferation, and cell death. Galectins are divided into three groups: prototype, tandem repeat a, and chimera type. Gal-2 belongs to the prototype group that includes Galectins 1, 2, 5, 7, 10, 11, 13, 14, and 15. The prototype galectins contain one carbohydrate recognition domain (CRD) and can form homodimers. Gal-2 shares 43% amino acid sequence identity with Gal-1. Studies in rat tissues and human tumor cell lines have shown that Gal-2 is expressed in gastrointestinal tract. Gal-2 induces apoptosis of lamina propria T lymphocytes, and ameliorates acute and chronic experimental colitis in mice. In addition, Gal-2 and Gal-1 induce phosphatidylserine exposure in fMLP-activated human neutrophils, but not in resting neutrophils. Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans, and Gal-2 and Gal-3 possesses higher binding than Gal-1 to fucose-containing A and B blood group antigensProduct Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant human Galectin-2 protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 10 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 0.1 - 1.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2783460 (BioLegend Cat. No. 856601)
AB_2783461 (BioLegend Cat. No. 856602)
- Human Galectin-2 is a 132 amino acid protein with a molecular mass of ~15 kD.
Tissue distribution: Highly expressed in gastrointestinal tract, and to lesser extent in the immune system, kidney, and brain.
Cellular distribution: Cytosol.
- Galectin-2 his involved in immune cell homeostasis, inflammation, cell adhesion and protein trafficking. The protein levels of Galectin-2, and also other Galectin proteins, are significantly increased in colon and breast cancer patients, promoting cancer cell adhesion.
Cellular targets: Interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α)
- Ligand Receptor
- CD14, Toll-like receptor (TLR)-4 pathway, glycoconjugates
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience
- Molecular Family
- Adhesion Molecules
- Antigen References
- Delacour D, et al. 2009. Traffic. 10(10):1405-13.
- Barrow H, et al. 2011. Clin Cancer Res. 17(22):7035-46.
- Rabinovich G.A., et al. 2002. Trends Immunol. 23(6):313-20.
- Yıldırım C. et al. 2015. PLoS One. 10(4):e0124347.
- Gene ID
- 3957 View all products for this Gene ID
- View information about Galectin-2 on UniProt.org
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