- CPTC-Fascin1-2 (See other available formats)
- Other Names
- FASN1, 55 kDa actin-bundling protein, Singed-like protein, p55
- Mouse IgG2a, κ
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- Product Citations
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Fascin is a 55 kD F-actin binding protein that is involved in cell motility and migration. Fascin plays an important role in the organization and formation of membrane ruffles, stress fibers, and a diverse set of cell protrusions, such as filopodia. In the mouse subventricular zone-derived migratory neuroblasts, Fascin is highly upregulated to guide the migration of cells along the rostral migratory stream. In Drosophila, Fascin controls neuronal class-specific dendrite arbor morphology to elicit the accurate establishment of neuronal circuits.Product Details
- Antibody Type
- Host Species
- Recombinant human Fascin full-length protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Human Fascin is a 493 amino acid protein with a molecular mass of 54 kD.
Tissue distribution: Ubiquitously expressed
Cellular distribution: Cytosol, cytoskeleton, and stress fibers
- Fascin is involved in the assembly of filamentous actin.
- Fascin interacts with RUFY3, beta-catenin, and PLXNB3.
- Cell Type
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroscience
- Molecular Family
- Cytoskeletal Proteins
- Antigen References
- Yamashiro S, et al. 1998. Mol Biol Cell. 9(5): 993-1006.
- Nagel J, et al. 2012. Development 139, 2999-3009
- Sonego M, et al. 2013. J Neurosci. 33(30): 12171–85.
- Gene ID
- 6624 View all products for this Gene ID
- View information about Fascin-1 on UniProt.org
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