- 8E5 (See other available formats)
- Other Names
- Mouse IgG1, κ
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Desmoglein 2 (DSG2) is a calcium-binding adhesion molecule that is highly expressed in epithelial cells and cardiomyocytes in vertebrates. DSG2 mainly locates to the intracellular adhesive junction called desmosome, which is a structure that functions in cell-to-cell adhesion. Clinically, mutations in DSG2 are mostly linked to cardiomyopathy. A recent GWAS study has shown that DSG2 is 1 of the 20 genetic risk factors that are associated with Alzheimer's disease.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg/ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2814633 (BioLegend Cat. No. 869401)
AB_2814634 (BioLegend Cat. No. 869402)
- DSG2 is a 1118 amino acid protein with predicted molecular mass of ~122 kD and observed molecular mass of ~150 kD.
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Plasma membrane
- DSG2 is localized to desmosomes and functions in cell-to-cell adhesion.
- DSG2 is an integral component of desmosomes.
- Cell Type
- Epithelial cells
- Biology Area
- Cell Adhesion, Neurodegeneration, Neuroinflammation, Synaptic Biology
- Molecular Family
- Adhesion Molecules
- Antigen References
- Kim JH. 2018. Dement Neurocogn Disord. 10.12779/dnd.2018.17.4.131.
- Harrison OJ, et al. 2016. Proc. Natl. Acad. Sci U S A. 113:7160-5.
- Gene ID
- 1829 View all products for this Gene ID
- View information about Desmoglein 2 on UniProt.org
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