- Poly28616 (See other available formats)
- Other Names
- GOT1, Aspartate Aminotransferase
- Rabbit Polyclonal IgG
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- Product Citations
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GOT1 is the cytoplasmic form of aspartate aminotransferase and plays a role in amino acid metabolism, and the tricarboxylic acid cycles. GOT1 is one of the 6 genes that is commonly shared and regulated in the aging population and AD patients, suggesting that it may contribute as an aging-dependent AD risk factor1.Product Details
- Antibody Type
- Host Species
- Recombinant Aspartate Aminotransferase (AST)
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 0.5 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- GOT1 is a 413 amino acid protein with an apparent molecular mass of ~ 46 kD.
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Cytosol and nucleus
- GOT1 is a cytoplasmic aspartate aminotransferase that plays a role in amino acid metabolism and the tricarboxylic acid cycles.
- Forms homodimer.
- Cell Type
- Astrocytes, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes
- Biology Area
- Neurodegeneration, Neuroinflammation, Neuroscience
- Antigen References
- Zheng JJ, et al. 2018. Medicine (Baltimore). 97(28):e11343
- Zhang K, et al. 2018. Mol Carcinog. 57(11):1566
- Gene ID
- 2805 View all products for this Gene ID
- View information about Aspartate Aminotransferase on UniProt.org
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