- O94E6/ARG1 (See other available formats)
- Regulatory Status
- Other Names
- Arginase 1, liver type Arginase, Type I Arginase, ARG1
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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ARG1 (Arginase 1), is a marker for the M2 anti-inflammatory macrophage subset that hydrolyzes l-arginine into urea and ornithine, and plays an important role in wound healing, antiviral immune responses, and atherosclerosis. The inherited deficiency of this enzyme results in argininemia, which is an autosomal recessive disorder characterized by hyperammonemia. Recent studies show that intracellular pathogens induce the expression of ARG1 in mouse macrophages through the Toll-like receptor (TLR) pathway. The deletion of this enzyme in macrophages favors host survival. Other studies indicate that ARG1 also plays a role in T cell responses and selective antagonists of ARG1 might prove beneficial in fighting diseases in which T-cell responses are inappropriately suppressed.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Full length recombinant human ARG1 protein produced in HEK293T cells.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
KO/KD-WB - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2566050 (BioLegend Cat. No. 678801)
AB_2566051 (BioLegend Cat. No. 678802)
- 322 amino acids with a predicted molecular weight of approximately 35 kD.
Expressed predominantly in the liver. It can also be induced in macrophages. Cytoplasmic.
- Arginase 1 plays an important role in processes such as wound healing, antiviral immune response, and atherosclerosis.
- Binds 2 manganese ions per subunit as a cofactor.
- Cell Type
- Dendritic cells, Macrophages
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience
- Molecular Family
- Enzymes and Regulators
- Antigen References
1. Wu G, et al. 1998. Biochem. J. 336:1.
2. El Kasmi KC, et al. 2008. Nat. Immunol. 9:1399.
3. Pesce JT, et al. 2009. PLoS Pathog. 5:e1000371.
4. Burrack KS, et al. 2014. Front Immunol. 5:428.
5. Pourcet B, et al. 2013. Trends Cardiovasc. Med. 23:143.
6. Bronte V, et al. 2003. Trends Immunol. 24:302.
- Gene ID
- 383 View all products for this Gene ID
- View information about Arginase 1 on UniProt.org
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