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APC anti-human CD365 (Tim-1) Antibody

Pricing & Availability
Clone
1D12 (See other available formats)
Regulatory Status
RUO
Workshop
HCDM listed
Other Names
T cell immunoglobulin mucin 1, TIMD-1, KIM-1 (kidney injury molecule-1), HAVCR-1, CD365
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
1D12_APC_Tim-1_Antibody_FC_092514
Human kidney cell line 769-P was stained with anti-human CD365 (Tim-1, clone 1D12) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
  • 1D12_APC_Tim-1_Antibody_FC_092514
    Human kidney cell line 769-P was stained with anti-human CD365 (Tim-1, clone 1D12) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).
Compare all formats See APC spectral data
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353905 25 tests £111
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353906 100 tests £256
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Description

CD365 (Tim-1) is a transmembrane glycoprotein expressed on activated CD4+ lymphocytes especially on Th2 cells. It has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is a hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in the costimulation of T cell proliferation. Tim-1 has been reported to be an endogenous ligand for LMIR5 (Leukocyte mono-immunoglobulin (Ig)-like receptor 5), and the Tim-1-LMIR5 interaction plays a physiological role in immune regulation by myeloid cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human TIM-1-IgV Fc
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported application (for the relevant formats) include: blocking function1.

Application References

(PubMed link indicates BioLegend citation)
  1. Freeman GJ, et al. 2007. Immunity. 27:927. (Block)
Product Citations
  1. Xue H, et al. 2016. PLoS One. 11: 0154815. PubMed
  2. Das A, et al. 2017. Mbio. 10.1128/mBio.00969-17. PubMed
  3. Omori S, et al. 2021. Cell Reports. 34(6):108734. PubMed
  4. Zapatero–Belinchón FJ, et al. 2019. Viruses. 11:3. PubMed
RRID
AB_2564324 (BioLegend Cat. No. 353905)
AB_2564325 (BioLegend Cat. No. 353906)

Antigen Details

Structure
Type 1 transmembrane glycoprotein.
Distribution

Activated CD4+ lymphocytes, especially on Th2 cells.

Function
TIM-1 ligation induces T cell proliferation, promotes cytokine production, and aids in the regulation of Th2 immunity.
Ligand/Receptor
TIM-4
Cell Type
Dendritic cells, T cells, Th2
Biology Area
Immunology, Inhibitory Molecules
Molecular Family
CD Molecules
Antigen References

1. Freeman GJ, et al. 2007. Immunity. 27:927.
2. Meyers JH, et al. 2005. Nat. Immunol. 6:455.
3. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
4. Mariat C, et al. 2005. Philos. Trans. R. Soc. Lond. B. 360:1681.
5. Yamanishi Y, et al. 2010. J. Exp. Med. 207:1501.

Gene ID
26762 View all products for this Gene ID
UniProt
View information about CD365 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 01/14/2015

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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