- MAR-1 (See other available formats)
- Regulatory Status
- Other Names
- FceRIa, FceRI-α, high affinity IgE receptor
- Armenian Hamster IgG
- Ave. Rating
- Submit a Review
- Product Citations
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FcεRIα is a transmembrane protein belonging to the Ig superfamily. FcεRIα forms a tetrameric complex with one β and two γ-subunits. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via FcεRIα, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcεRIα subunit.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Armenian Hamster
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA.
- The antibody was purified by affinity chromatography.
- 1.0 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
CyTOF® - Verified
- Recommended Usage
This product is suitable for use with the Maxpar® Metal Labeling Kits. For metal labeling using Maxpar® Ready antibodies, proceed directly to the step to Partially Reduce the Antibody by adding 100 µl of Maxpar® Ready antibody to 100 µl of 4 mM TCEP-R in a 50 kDa filter and continue with the protocol. Always refer to the latest version of Maxpar® User Guide when conjugating Maxpar® Ready antibodies.
- Application Notes
Additional reported applications (for relevant formats of this clone) include: depletion2, immunohistochemistry of frozen sections (OCT embedded2).
- Additional Product Notes
Maxpar® is a registered trademark of Standard BioTools Inc.
- Application References
- Obata K, et al. 2007. Blood 110:913 (FC)
- Sokol CL, et al. 2008. Nat. Immunol. 9:310 (FC, Deplete, IHC)
- Chen J, et al. 2009. J. Biol. Chem.. 284:5763 (FC)
- Product Citations
AB_2563768 (BioLegend Cat. No. 134321)
- A transmembrane protein of Ig super family member
Expressed on mast and basophils.
- Play an important role in triggering IgE-mediated allergic reactions.
- Cell Type
- Basophils, Mast cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules, Fc Receptors
- Antigen References
1. Arinobu Y, et al. 2005. P. Natl. Acad. Sci. USA 102:18105.
2. Yamaguchi M, et al. 2001. Int. Immunol. 13:843.
- Gene ID
- 2205 View all products for this Gene ID
- View information about FcepsilonRIalpha on UniProt.org
Related Pages & Pathways
- Can I obtain CyTOF data related to your Maxpar® Ready antibody clones?
We do not test our antibodies by mass cytometry or on a CyTOF machine in-house. The data displayed on our website is provided by Fluidigm®. Please contact Fluidigm® directly for additional data and further details.
- Can I use Maxpar® Ready format clones for flow cytometry staining?
We have not tested the Maxpar® Ready antibodies formulated in solution containing EDTA for flow cytometry staining. While it is likely that this will work in majority of the situations, it is best to use the non-EDTA formulated version of the same clone for flow cytometry testing. The presence of EDTA in some situations might negatively affect staining.
- I am having difficulty observing a signal after conjugating a metal tag to your Maxpar® antibody. Please help troubleshoot.
We only supply the antibody and not test that in house. Please contact Fluidigm® directly for troubleshooting advice: http://techsupport.fluidigm.com/
- Is there a difference between buffer formulations related to Maxpar® Ready and purified format antibodies?
The Maxpar® Ready format antibody clones are formulated in Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and EDTA. The regular purified format clones are formulated in solution that does not contain any EDTA. Both formulations are however without any extra carrier proteins.
Other FormatsView All FcεRIα Reagents Request Custom Conjugation
|Purified anti-mouse FcεRIα||MAR-1||FC,IHC-F|
|Biotin anti-mouse FcεRIα||MAR-1||FC|
|FITC anti-mouse FcεRIα||MAR-1||FC|
|PE anti-mouse FcεRIα||MAR-1||FC|
|Alexa Fluor® 647 anti-mouse FcεRIα||MAR-1||FC|
|Pacific Blue™ anti-mouse FcεRIα||MAR-1||FC|
|APC anti-mouse FcεRIα||MAR-1||FC|
|PE/Cyanine7 anti-mouse FcεRIα||MAR-1||FC|
|PerCP/Cyanine5.5 anti-mouse FcεRIα||MAR-1||FC|
|Purified anti-mouse FcεRIα (Maxpar® Ready)||MAR-1||FC,CyTOF®|
|Alexa Fluor® 700 anti-mouse FcεRIα||MAR-1||FC|
|APC/Cyanine7 anti-mouse FcεRIα||MAR-1||FC|
|PE/Dazzle™ 594 anti-mouse FcεRIα||MAR-1||FC|
|Alexa Fluor® 488 anti-mouse FcεRIα||MAR-1||FC|
|Brilliant Violet 510™ anti-mouse FcεRIα||MAR-1||FC|
|TotalSeq™-A0115 anti-mouse FcεRIα||MAR-1||PG|
|Ultra-LEAF™ Purified anti-mouse FcεRIα||MAR-1||FC,IHC-F|
|TotalSeq™-C0115 anti-mouse FcεRIα||MAR-1||PG|
|TotalSeq™-B0115 anti-mouse FcεRIα||MAR-1||PG|
|APC/Fire™ 750 anti-mouse FcεRIα||MAR-1||FC|
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
Purified anti-mouse FcεRIα
Biotin anti-mouse FcεRIα
FITC anti-mouse FcεRIα
PE anti-mouse FcεRIα
Alexa Fluor® 647 anti-mouse FcεRIα
Pacific Blue™ anti-mouse FcεRIα
APC anti-mouse FcεRIα
PE/Cyanine7 anti-mouse FcεRIα
PerCP/Cyanine5.5 anti-mouse FcεRIα
Purified anti-mouse FcεRIα (Maxpar® Ready)
Alexa Fluor® 700 anti-mouse FcεRIα
APC/Cyanine7 anti-mouse FcεRIα
PE/Dazzle™ 594 anti-mouse FcεRIα
Alexa Fluor® 488 anti-mouse FcεRIα
Brilliant Violet 510™ anti-mouse FcεRIα
TotalSeq™-A0115 anti-mouse FcεRIα
Ultra-LEAF™ Purified anti-mouse FcεRIα
TotalSeq™-C0115 anti-mouse FcεRIα
TotalSeq™-B0115 anti-mouse FcεRIα
APC/Fire™ 750 anti-mouse FcεRIα