- N227/21 (See other available formats)
- Regulatory Status
- Other Names
- Methyl-CpG-binding protein 2, meCp-2 protein, RS, RTS, RTT, PPMX, MRX16, MRX79, MRXSL, AUTSX3, MRXS13
- Mouse IgG1, κ
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- Product Citations
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Methyl CpG binding protein (MECP2), also known as autism susceptibility to X-linked 2 (AUTSX3), is a nuclear protein crucial for normal neuronal function that binds to methylated DNA, forming complexes with histone deacteylases and turning off gene expression. MECP2 expression is an X-linked trait. Loss of MECP2 expression causes Rett Syndrome (also known as RTS, RTT, or RS) a neurological disorder which causes decelerated growth of hands, feet, and the head.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- This monoclonal antibody was raised against a synthetic peptide corresponding to amino acids 157-169 (FTVTG[dimethyl-R]GSPSRRE) of human MECP2.
- This antibody is provided in 50% glycerol in aqueous buffered solutions with preservatives.
- The antibody was purified by affinity chromatography and conjugated with HRP under optimal conditions.
- 0.5 mg/mL
- Storage & Handling
- Upon receipt, the antibody solution should be stored undiluted at -20°C, and protected from prolonged exposure to light.
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Additional Product Notes
The reactivity of HRP anti-MECP2 antibody was verified in FFPE mouse and rat brain tissue.
AB_2734566 (BioLegend Cat. No. 814003)
AB_2734567 (BioLegend Cat. No. 814004)
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