Purified anti-Tubulin β 3 (TUBB3) Antibody (Previously Covance catalog# MMS-435P)

Pricing & Availability
Clone
TUJ1 (See other available formats)
Other Names
CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, Tubulin beta-3 chain, tubulin beta-III, tubulin beta-4 chain, class III beta-tubulin
Previously
Covance Catalog# MMS-435P
Isotype
Mouse IgG2a, κ
Ave. Rating
15 reviews
Product Citations
publications
A_TUJ1_PURE_Tubulin-beta3_IHCP_Hu_011618
IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded human brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • A_TUJ1_PURE_Tubulin-beta3_IHCP_Hu_011618
    IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded human brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • B_TUJ1_PURE_Tubulin-beta3_IHCP_Rat_011618
    IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded rat brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • C_TUJ1_PURE_Tubulin-beta3_WB_011618
    Western blot of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of Mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blots were incubated with 1 ug/mL of TUJ1 or mouse IgG overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • D_TUJ1_PURE_Tubulin-beta3_ICC_011618
    ICC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on SH-SY5Y neuroblastoma cells. The cells were fixed by 4% PFA, permeabilized with a buffer containing 0.1% Triton X-100 and 0.25% BSA, and blocked with 2% Normal Goat Serum and 0.02% BSA. The cells were then incubated with 1 µg/mL of the primary antibody for 3 hours at room temperature, followed by incubation with 0.5 µg/mL Alexa Fluor® 594 goat anti-mouse IgG (Cat. No. 405326) for 1 hour at room temperature. Nuclei were counterstained with DAPI. The image was captured with a 60X objective Scale bar: 20 µm
  • E_Ankita_Patil
    Methanol fixed superior cervical ganglion neurons were stained with anti-tubulin β3 (pink) and anti-TRIM46 (aqua), then stained with secondary antibodies, phalloidin (orange) and DAPI (blue). Image generously submitted to the 2017 Cell Life Imaging Competition by Ankita Patil from Drexel University.
Cat # Size Price Quantity Avail. Save
801213 25 µL 72€
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801201 100 µL 180€
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801202 250 µL 266€
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Description

Tubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors. Studies indicate that it is a predictive and prognostic marker in various tumors.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This antibody was raised against microtubules derived from rat brain.
Formulation
Phosphate-buffered solution + 0.03% Thimerosal.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1.0 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

IHC-P - Quality tested
WB, ICC - Validated
FC - Reported in the literature

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg/ml is suggested. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg/ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: flow cytometry4, immunofluorescence microscopy1-5,7, immunohistochemistry5,7, and Western blotting8.

This antibody is well characterized and highly reactive to neuron specific Class III β-tubulin (βIII). TUJ1 does not identify β-tubulin found in glial cells. TUJ1 recognizes an epitope located within the last 15 C-terminal residues8.

Application References
  1. Nishimura K, et al. 2017. PLoS One. 12(1): e0170568. (ICC)
  2. Jongbloets J, et al. 2017. Nat Commun. 8: 14666. (ICC) PubMed
  3. Liu W.J, et al. 2015. Eur J Histochem. 59(1): 2464. (ICC) PubMed
  4. Chintalapudi SR, et al. 2016. Front Aging Neursci. 8:93. (FC, ICC) PubMed
  5. Ambasudhan R, et al. 2011. Cell Stem Cell. 9(2):113. (IHC, ICC)
  6. Hu X., et al. 2006. Nature Neuroscicene. 9(12):1520. (WB) PubMed
  7. Zechner D., et al. 2003. Develop Biology. 258(2):406. (ICC, IHC)
  8. Lee MK, et al. 1990. Proc. Natl. Acad. Sci. USA 18:7195. (WB)
Product Citations
  1. Kim K, et al. 2015. PLoS One. 10: 0142693. PubMed
  2. Jouhilahti E, et al. 2008. J Histochem Cytochem. 56:1113-1119. PubMed
  3. Barry D, et al. 2012. J Neurosci. 32:6209-6219. PubMed
  4. Ferletta M, et al. 2011. Int J Cancer. 129:45-60. PubMed
  5. Wirt S, et al. 2010. J Cell Biol. 191:809-825. PubMed
  6. Cesca F, et al. 2012. Cell Death Differ. 19:194-208. PubMed
  7. Kim K, et al. 2013. J Cell Biol. 200:443-458. PubMed
  8. Flores-Otero J, et al. 2007. J Neurosci. 27:14023-14034. PubMed
  9. Wang Q, et al. 2016. Sci Rep. 6:19003. PubMed
  10. Kizuka Y, et al. 2016. Biochem J. 473: 21 - 30. PubMed
  11. Dudok J, et al. 2016. Neurosci Res. S0168-0102(16)00002-X. PubMed
  12. Caiazzo M, et al. 2016. Nat Mater. 0.1038/nmat4536. PubMed
  13. Rraklli V, et al. 2016. Stem Cell Res. 16:1-9. PubMed
  14. Rooney G, et al. 2016. J Neurosci. 36: 142 - 152.. PubMed
  15. Fan C, et al. 2016. Sci Rep. 6:19579. PubMed
  16. Kishi N, et al. 2016. Nat Commun. 7:10520. PubMed
  17. Nawaz M, et al. 2016. PLoS One. 11: 0148634. PubMed
  18. Mazzulli J, et al. 2016. Proc Natl Acad Sci U S A. 113: 1931 - 1936. PubMed
  19. Ulbrich L, et al. 2016. Biochem J. 473: 423 - 434. PubMed
  20. Taverna E, et al. 2016. Sci Rep. 6:21206. PubMed
  21. Long K, et al. 2016. Nat Commun. 7:10354. PubMed
  22. Sancho-Martinez I, et al. 2016. Nat Commun. 7:10743. PubMed
  23. Jablonski K, et al. 2016. Stem Cell Reports. 8: 1119-1127. PubMed
  24. He H, et al. 2016. J Neurosci. 36: 3079 - 3091. PubMed
  25. Tanimoto R, et al. 2016. Sci Rep. 6:22071. PubMed
  26. Mita T, et al. 2016. J Biol Chem. 291: 4955 - 4965. PubMed
  27. Binder Z, et al. 2016. PLoS One. 11: 0150271. PubMed
  28. Wang W, et al. 2016. Nat Commun. 7:10936. PubMed
  29. Intoh A, et al. 2016. Hum Mol Genet. 10.1093/hmg/ddw053. PubMed
  30. Petracca Y, et al. 2016. Development. 143: 880 - 891. PubMed
  31. Pinto M, et al. 2016. J Cell Biol. 212: 789 - 801. PubMed
  32. Nagao M, et al. 2016. Nat Commun. 7:11102. PubMed
  33. Lalli M, et al. 2016. Hum Mol Genet. 25: 1294-1306. PubMed
  34. Paquet D, et al. 2016. Nature. 533: 125-129. PubMed
  35. Okamoto M, et al. 2016. Nat Commun. 7: 11349. PubMed
  36. Xue Y, et al. 2016. Nat Neurosci. 19: 807-15. PubMed
  37. Wang L, Hou S, Han Y 2016. Nat Neurosci. 19: 888-896. PubMed
  38. Takeo Y, et al. 2016. Sci Rep. 6: 25180. PubMed
  39. Kida H, et al. 2016. Cereb Cortex. 10.1093/cercor/bhw134. PubMed
  40. Soares V, et al. 2016. Neuro Oncology. 10.1093/neuonc/now099. PubMed
  41. Itoh Y, et al. 2016. Proc Natl Acad Sci U S A. 113: 2955 - 2964. PubMed
  42. Vanderperre B, et al. 2016. PLoS Genet. 12: 1006056. PubMed
  43. George L, et al. 2016. Dev Biol. 413:70-85. PubMed
  44. Thakurela S, et al. 2016. Sci Rep. 6: 25828. PubMed
  45. Kushwaha R, et al. 2016. Stem Cell Reports. 6:772-783. PubMed
  46. Liu X, et al. 2016. Nat Commun. 7:11508. PubMed
  47. Fame R, et al. 2016. J Neurosci. 36: 6403 - 6419. PubMed
  48. Haas M, et al. 2016. Cell Rep. 15:2251-2265. PubMed
  49. Bedogni F, et al. 2016. Cereb Cortex. 26: 2517 - 2529. PubMed
  50. Edmondson R, Adock A, Yang L 2016. PLoS One. 11: 0158116. PubMed
  51. Quintes S, et al. 2016. Nat Neurosci. 10.1038/nn.4321. PubMed
  52. Marchetto M, et al. 2016. Mol Psychiatry. 10.1038/mp.2016.95. PubMed
  53. Muscat A, et al. 2016. Clin Cancer Res. 22: 3560 - 3570. PubMed
  54. Guo S, Du Y, Liu X 2016. Nat Commun. 7:12230. PubMed
  55. Demais V, et al. 2016. J Neurosci. 36: 8012 - 8025. PubMed
  56. Li S, et al. 2016. Sci Rep. 6:29514. PubMed
  57. Drobish J, et al. 2016. Toxicol Sci. 154(2):309-319. PubMed
  58. Borromeo M, et al. 2016. Cell Rep. 16:1259-1272. PubMed
  59. Maison S, Liberman L, Liverman M 2016. eNeuro. 3: ENEURO.0207-16.2016. PubMed
  60. Roese-Koerner B, et al. 2016. Stem Cell Reports. 7:207-219. PubMed
  61. Zalfa C, et al. 2016. Cell Death Dis. 7:e2331. PubMed
  62. Borgs L, et al. 2016. Sci Rep. 6: 33377. PubMed
  63. Wang T, et al. 2016. Nat Commun. 7: 12976. PubMed
  64. Mikami Y, et al. 2016. EBioMedicine. 11: 253-261. PubMed
  65. Sadick J, et al. 2016. Sci Rep. 6: 33999. PubMed
  66. Gai M, et al. 2016. EMBO Rep. 17: 1396 - 1409. PubMed
  67. Durak O, et al. 2016. Nat Neurosci. 19:1477-1488. PubMed
  68. Gaitán-Peñas H, et al. 2016. Biophys J. 111:1429-1443. PubMed
  69. Martin C, et al. 2016. Genes Dev. 30: 2158 - 2172. PubMed
  70. Pei S, et al. 2016. Sci Rep. 6:33822. PubMed
  71. Hegazy A, et al. 2016. J Biol Chem. 291: 21496 - 21509. PubMed
  72. Zeltner N, et al. 2016. Nat Med. 22:1421-1427. PubMed
  73. M Rodriguez, S Noctor, E Muñoz 2016. PLoS One. 11:e0167063. PubMed
  74. Damiani D, et al. 2016. Nat Commun. 7:13509. PubMed
  75. Rubio A, et al. 2016. Sci Rep. 6:37540. PubMed
  76. Okamoto-Uchida Y, et al. 2016. Sci Rep. 6:37697. PubMed
  77. Fimiani C, et al. 2016. Sci Rep. 6:39311. PubMed
  78. Jiang G, et al. 2016. Stem Cells Trans Med. 5(12):1595-1606. PubMed
  79. Nonomura K, et al. 2016. Nature. 541:176-181. PubMed
  80. Laura Kerosuo, Marianne E. Bronner 2016. Cell Rep. 17:2648-2659. PubMed
  81. Jager P, et al. 2016. Nat Commun. 7:13579. PubMed
  82. Teresa Rivera, Candy Haggblom, Sandro Cosconati 2016. Nat Struct Mol Biol. 24:30-39. PubMed
  83. Chen W, et al. 2017. eNeuro. 3(6). PubMed
  84. LI Y, et al. 2017. Proc Natl Acad Sci U S A. 114(2):E209-E218. PubMed
  85. Sandor C, et al. 2017. Hum Mol Genet. 10.1093/hmg/ddw412. PubMed
  86. Shi W, et al. 2017. Nat Neurosci. 10.1038/nn.4519. PubMed
  87. Friocourt F, et al. 2017. Sci Rep. 7:37569. PubMed
  88. Landegger L, et al. 2017. Nat Biotechnol. 35:280-284. PubMed
  89. Ueki J, et al. 2017. Sci Rep. 7:42522. PubMed
  90. Johansson E, et al. 2017. Cell Rep. 10.1016/j.celrep.2017.07.049. PubMed
  91. Liu P, et al. 2017. Stem Cell Rep. 10.1016/j.stemcr.2017.05.007. PubMed
  92. Ogawa Y, et al. 2017. PLoS One. 12(6):e0178978. PubMed
  93. Hackelberg S, et al. 2017. PLoS One. 10.1371/journal.pone.0180427. PubMed
  94. Coste C, et al. 2017. PLoS One. 10.1371/journal.pone.0177962. PubMed
  95. Flaherty E,et al. 2017. NPJ Schizophr.. 10.1038/s41537-017-0033-5. PubMed
  96. Miranda AM, et al. 2018. Nat Commun. 9:291. PubMed
  97. Allende ML, et al. 2018. J Lipid Res. 59:550. PubMed
  98. Janssens S, et al. 2018. mSystems. 3. PubMed
  99. Muthusamy N, et al. 2018. Sci Rep. 8:1766. PubMed
  100. Kuwahara H, et al. 2018. Sci Rep. 8:4377. PubMed
  101. Goffena J, et al. 2018. Nat Commun. 9:889. PubMed
  102. Ryan T, et al. 2018. Nat Commun. 9:817. PubMed
  103. Chau KF, et al. 2018. Elife. 19:E663. PubMed
  104. Luisier R, et al. 2018. Nat Commun. 8:6458. PubMed
  105. Urrea L, et al. 2018. Mol Neurobiol. 15:1630. PubMed
  106. Stepp MA, et al. 2018. Exp Eye Res. 10:113. PubMed
  107. Boyer NP, et al. 2018. Eneuro. 55:1847. PubMed
  108. Park SY, et al. 2018. Mol Brain. 169:91. PubMed
  109. Liu C, et al. 2018. Stem Cell Reports. 4:43. PubMed
  110. Playne R, et al. 2018. J Stem Cells Regen Med. 7:e36998. PubMed
  111. Valdez C, et al. 2017. Hum Mol Genet. 26:4861. PubMed
  112. Augé E, et al. 2018. Sci Rep. 8:13525. PubMed
  113. Bachmann SO, et al. 2019. Transl Psychiatry. 9:29. PubMed
  114. Amaral JD, et al. 2019. Front Chem. 7:15. PubMed
  115. Hor JH, et al. 2018. Cell Death Dis. 9:1100. PubMed
  116. Xu Z, et al. 2019. Front Neurosci. 12:970. PubMed
  117. Trajkovic K, et al. 2019. PLoS One. 14:e0211727. PubMed
  118. Gao L, et al. 2019. Sci Rep. 9:3462. PubMed
  119. Cheng LS, et al. 2017. Pediatr Res. 81:838. PubMed
  120. Sabo JK, et al. 2017. Ann Neurol. 81:560. PubMed
  121. Toda T, et al. 2017. Cell Stem Cell. 21:618. PubMed
  122. Makar T, et al. 2018. Stem Cell Res Ther. 9:127. PubMed
  123. Liu WA, et al. 2018. Genes Dev. 32:763. PubMed
  124. Xu Z, et al. 2018. Development. 145:. PubMed
  125. Spitalieri P, et al. 2018. Front Physiol. 9:967. PubMed
  126. Han S, et al. 2018. Development. 145:. PubMed
  127. Ding D, et al. 2018. J Otol. 13:115. PubMed
  128. Erwig MS, et al. 2019. Elife. 8:. PubMed
  129. Hu X, et al. 2019. Stem Cell Reports. 12:290. PubMed
  130. Roselló-Busquets C, et al. 2019. Front Cell Neurosci. 13:40. PubMed
  131. Liu H, et al. 2019. Front Cell Neurosci. 13:60. PubMed
  132. Tohgi N, et al. 2017. Cell Cycle. 16:95. PubMed
  133. Xue J, et al. 2017. ACS Appl Mater Interfaces. 9:12299. PubMed
  134. Sun L, et al. 2017. Oncotarget. 8:40065. PubMed
  135. Howlett EH, et al. 2017. Hum Mol Genet. 26:4340. PubMed
  136. Teng X, et al. 2018. Thyroid. 28:667. PubMed
  137. Fernandes KA, et al. 2018. Exp Eye Res. 171:54. PubMed
  138. Stallings NR, et al. 2018. Sci Signal. 11:522. PubMed
  139. Christiansen EM, et al. 2018. Cell. 173:792. PubMed
  140. Acosta S, et al. 2018. Genesis. 56:e23212. PubMed
  141. Rich CA, et al. 2018. Glia. 66:2617. PubMed
  142. Stepp MA, et al. 2018. Int J Mol Sci. 19:12. PubMed
  143. Pronin A, et al. 2019. Front Mol Neurosci. 12:36. PubMed
  144. Vyas P, et al. 2019. Sci Rep. 9:5549. PubMed
  145. Thayer JA, et al. 2019. Autophagy. 7:1-14. PubMed
  146. Heil C, et al. 2019. Open Biol. 9:180145. PubMed
  147. Kirihara T, et al. 2019. iScience. 14:301. PubMed
  148. Calatayud C, et al. 2019. Sci Rep. 9:6811. PubMed
  149. Zhang N, et al. 2019. Adv Sci (Weinh). 6:1800808. PubMed
  150. Laussu J, et al. 2017. Neural Dev. 12:10. PubMed
  151. Tramarin M, et al. 2018. Hum Mol Genet. 27:2052. PubMed
  152. Nicole O, et al. 2018. Mol Psychiatry. 23:2209. PubMed
  153. Vinci M, et al. 2018. Nat Med. 24:1204. PubMed
  154. González C, et al. 2018. Mol Psychiatry. 23:2363. PubMed
  155. Hu D, et al. 2019. Acta Neuropathol. 137:939. PubMed
  156. Wanner R, et al. 2019. Front Neurol. 10:310. PubMed
  157. Friedl RM, et al. 2019. Dis Model Mech. 0.5. PubMed
  158. Lee J, et al. 2018. Invest Ophthalmol Vis Sci. 59:3531. PubMed
  159. Stylianou N, et al. 2019. Oncogene. 38:913. PubMed
  160. Sun Z, et al. 2019. Nat Commun. 10:3892. PubMed
  161. Sanli I, et al. 2018. Cell Rep. 23:337. PubMed
  162. Cha HL, et al. 2019. Mol Brain. 12:57. PubMed
  163. Miltner AM, et al. 2019. Int J Mol Sci. 20. PubMed
  164. Lenz KM, et al. 2018. J Neurosci. 38:8044. PubMed
  165. Coleman JH, et al. 2019. J Neurosci. 39:814. PubMed
  166. Moakley D, et al. 2019. Sci Rep. 9:10835. PubMed
  167. Gao L, et al. 2019. Front Cell Neurosci. 13:316. PubMed
  168. Sarkar C, et al. 2019. Autophagy. N/A. PubMed
  169. Raspa A, et al. 2019. CNS Neurosci Ther. 25:86. PubMed
  170. Barbiero I, et al. 2017. Hum Mol Genet. 26:3520. PubMed
  171. Malkemper EP, et al. 2018. Biol Open. 7:bio034462. PubMed
  172. Kim J, et al. 2018. Development. 145. PubMed
  173. Mo J, et al. 2017. Invest Ophthalmol Vis Sci. 58:137. PubMed
  174. Singh K, et al. 2018. Front Mol Neurosci. 11:30. PubMed
  175. Kim J, et al. 2017. Histochem Cell Biol. 148:489. PubMed
  176. Suarato G, et al. 2017. Biomaterials. 112:176. PubMed
  177. Khayati K, et al. 2017. FASEB J. 31:598. PubMed
  178. Sorrells SF, et al. 2019. Nat Commun. 10:2748. PubMed
  179. Tiihonen J, et al. 2019. Nat Commun. 10:3933. PubMed
  180. Poulopoulos A, et al. 2019. Nature. 565:356. PubMed
  181. Croteau LP, et al. 2019. Sci Rep. 9:12009. PubMed
  182. Boso D, et al. 2019. Theranostics. 9:4860. PubMed
  183. Canali G, et al. 2018. Hum Mol Genet. 27:1941. PubMed
  184. Van Der Raadt J, et al. 2019. Nucleic Acids Res. 47:5587. PubMed
  185. Hockman D, et al. 2018. Dev Biol. 444:s308. PubMed
  186. Mohlin S, et al. 2019. EMBO Mol Med. 11:e10058. PubMed
  187. Kaur T, et al. 2019. Front Neurosci. 13:620. PubMed
  188. Vassilev V, et al. 2017. Dev Cell. 43:463. PubMed
  189. Haverfield JT, et al. 2017. Reprod Fertil Dev. 29:609. PubMed
  190. Duan RS, et al. 2018. Cell Death Differ. 25:1598. PubMed
  191. Watanabe Y, et al. 2018. Development. 145. PubMed
  192. Kurabayashi N, et al. 2018. Development. 145. PubMed
  193. Boucherie C, et al. 2018. Mol Psychiatry. 23:723. PubMed
  194. Fujitani M, et al. 2017. Mol Psychiatry. 22:364. PubMed
  195. Tiethof AK, et al. 2018. Toxics. 6:52. PubMed
  196. Enriquez‐Rios V et al. 2017. The Journal of Neuroscience. 37(4):893-905 . PubMed
  197. Marlier Q et al. 2018. Cell Death Discov. 4:43 . PubMed
  198. Wu X et al. 2018. Cell. 172(3):423-438 . PubMed
  199. Sevilla A et al. 2018. Stem cell research. 29:99-102 . PubMed
  200. Buijsen RAM et al. 2018. Stem cell research. 29:125-128 . PubMed
  201. Sommer A et al. 2018. Cell stem cell. 23(1):123-131 . PubMed
  202. Merten N et al. 2018. Cell chemical biology. 25(6):775-786 . PubMed
  203. Miquel‐Serra L et al. 2018. Stem cell research. 24:155-159 . PubMed
  204. Mura M et al. 2018. Stem cell research. 29:157-161 . PubMed
  205. Mains RE et al. 2018. Endocrinology. 159(7):2621-2639 . PubMed
  206. Umegaki Y et al. 2018. The Journal of Neuroscience. 38(21):4985-4995 . PubMed
  207. Tandon R et al. 2018. Stem cell research. 33:120-124 . PubMed
  208. Amrita Pathak et al. 2018. Developmental cell. 46(3):376-387 . PubMed
  209. Lee SW et al. 2018. Developmental cell. 46(1):73-84 . PubMed
  210. Lee SY et al. 2018. Stem cell research. 30:145-149 . PubMed
  211. Hermanto Y et al. 2018. Journal of neuroscience research. 96(5):863-874 . PubMed
  212. Thomas RA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  213. Millan‐Zambrano G et al. 2018. Molecular cell. 72(4):625-635 . PubMed
  214. Anne Jacob et al. 2018. Journal of neurochemistry. 146(3):251-268 . PubMed
  215. Cárdenas A et al. 2018. Cell. 174(3):590-606 . PubMed
  216. Sun S et al. 2018. Cell. 174(5):1247-1263 . PubMed
  217. Tavano S et al. 2018. Neuron. 97(6):1299-1314 . PubMed
  218. Lehtonen Ŝ et al. 2018. Stem cell research. 30:96-99 . PubMed
  219. Moon KH et al. 2018. Developmental cell. 44(1):13-28 . PubMed
  220. Oksanen M et al. 2018. Stem cell research. 31:181-185 . PubMed
  221. Senft AD et al. 2018. Cell reports. 24(8):1977-1985 . PubMed
  222. Erin Frey et al. 2018. eNeuro. 5(3) pii: ENEURO. PubMed
  223. Kelly SM et al. 2018. Neuron. 99(2):345-361 . PubMed
  224. Liu Y et al. 2018. Cell stem cell. 23(5):758-771 . PubMed
  225. Kaur T et al. 2018. The Journal of comparative neurology. 526(5):824-835 . PubMed
  226. Fan L et al. 2018. eLife. 7 pii: e35242. PubMed
  227. Chia PH et al. 2018. eLife. 7 pii: e32451. PubMed
  228. Valadas JS et al. 2018. Neuron. 98(6):1155-1169 . PubMed
  229. Vitali I et al. 2018. Cell. 174(5):1264-1276 . PubMed
  230. Mura M et al. 2018. Stem cell research. 29:170-173 . PubMed
  231. Tripathy R et al. 2018. Neuron. 100(6):1354-1368 . PubMed
  232. Knudsen JG et al. 2018. Cell metabolism. 29(2):430-442 . PubMed
  233. Lehrman EK et al. 2018. Neuron. 100(1):120-134 . PubMed
  234. Shin BC et al. 2018. The Journal of Neuroscience. 38(44):9579-9599 . PubMed
  235. Yi‐Lan Weng et al. 2018. Neuron. 97(2):313-325 . PubMed
  236. Qiang L et al. 2018. Current biology : CB. 28(13):2181-2189 . PubMed
  237. Zahr SK et al. 2018. Neuron. 97(3):520-537 . PubMed
  238. Liu L et al. 2017. Cell metabolism. 26(5):719-737 . PubMed
  239. Debadrita Bhattacharya et al. 2018. eLife. 7 pii: e40556. PubMed
  240. Gupta S et al. 2017. Journal of neurochemistry. 145(3):188-203 . PubMed
  241. Joanna Ruth Appel et al. 2018. The Journal of Neuroscience. 38(26):5949-5968 . PubMed
  242. Diacou R et al. 2018. Cell reports. 25(9):2510-2523 . PubMed
  243. Lang C et al. 2019. Cell stem cell. 24(1):93-106 . PubMed
  244. Luo C et al. 2019. eLife. 8 pii: e40197. PubMed
  245. Zunke F et al. 2017. Neuron. 97(1):92-107 . PubMed
  246. Pai EL et al. 2019. Cell reports. 26(5):1157-1173 . PubMed
  247. Linkous A et al. 2019. Cell reports. 26(12):3203-3211 . PubMed
  248. Wang G et al. 2019. eLife. 8 pii: e38730. PubMed
  249. Hickey SL et al. 2019. Cell reports. 27(6):1699-1711 . PubMed
  250. Meijer M et al. 2019. Cell Rep. 27(7):2199-2211 . PubMed
  251. Rhee HJ et al. 2019. Cell Rep. 27(7):2212-2228 . PubMed
  252. Alexander JM et al. 2019. Elife. 8 pii: e41769. PubMed
  253. Yang T et al. 2018. Cell reports. 24(10):2694-2708 . PubMed
  254. Shao Q et al. 2019. PLoS One. 14(6):e0218811 . PubMed
  255. Nash B et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed
  256. Lin CI et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed
  257. Miesfeld JB et al. 2017. Gene expression patterns : GEP. 27:114-121 . PubMed
  258. Nam H et al. 2019. Elife. 8 pii: e46683. PubMed
  259. Stratton JA et al. 2018. Cell reports. 24(10):2561-2572 . PubMed
  260. Velychko S et al. 2019. Cell reports. 27(1):30-39 . PubMed
  261. Sarah E Pease‐Raissi et al. 2017. Neuron. 96(2):373-386 . PubMed
  262. Ibañez Rodriguez MP et al. 2018. The Journal of comparative neurology. 526(15):2462-2481 . PubMed
  263. Fan D et al. 2019. Elife. 8 pii: e49226. PubMed
  264. Park KK et al. 2017. The Journal of comparative neurology. 525(2):380-388 . PubMed
  265. Child KM et al. 2018. The Journal of Neuroscience. 38(31):6806-6824 . PubMed
  266. Chanda S et al. 2019. Cell Stem Cell. 25(1):103-119 . PubMed
  267. Chang CH et al. 2019. Developmental cell. 48(2):184-199 . PubMed
  268. Ioannou MS et al. 2019. Curr Protoc Cell Biol. 84(1):e95 . PubMed
  269. Ioannou MS et al. 2019. Cell. 177(6):1522-1535 . PubMed
  270. Ogawa Y et al. 2019. Neurosci Res. pii: S0168-0102(19)30120-8 . PubMed
  271. Neurohr GE et al. 2019. Cell. 176(5):1083-1097 . PubMed
  272. Wu Z et al. 2019. Neuron. 101(4):635-647 . PubMed
  273. Gao F et al. 2019. Mol Cell. 75(5):891-904 . PubMed
  274. Daoutsali E et al. 2019. Stem Cell Res. 1723:19:00 . PubMed
  275. Schreurs RRCE et al. 2019. Immunity. 50(2):462-476 . PubMed
  276. Paonessa F et al. 2019. Cell reports. 26(3):582-593 . PubMed
  277. Murcia‐Belmonte V et al. 2019. Current biology : CB. 29(7):1149-1160 . PubMed
  278. Arellano‐Viera E et al. 2019. Stem cell research. 1726:10:00 . PubMed
  279. Leibinger M et al. 2019. Commun Biol. 0.304166667 . PubMed
  280. Vicario N et al. 2019. Molecular neurobiology. 56(11):7338-7354 . PubMed
  281. Hermanto Y et al. 2019. Journal of neuroscience research. 97(7):828-845 . PubMed
  282. Di Bella DJ et al. 2019. Cell Rep. 28(9):2264-2274 . PubMed
  283. Pollen AA et al. 2019. Cell. 176(4):743-756 . PubMed
  284. Freeman S et al. 2019. EMBO Rep. 20(9):e47097 . PubMed
  285. Auboyer L et al. 2019. Stem Cell Res. 1723:41:00 . PubMed
  286. Sharma N et al. 2019. Neuron. 102(2):390-406 . PubMed
  287. Friocourt F et al. 2019. The Journal of comparative neurology. 527(12):2009-2029 . PubMed
  288. Mura M et al. 2019. Stem Cell Res. 1727:31:00 . PubMed
  289. Comai G et al. 2019. Elife. 8 pii: e47460. PubMed
  290. Mura M et al. 2019. Stem cell research. 1726:16:00 . PubMed
  291. Hertz NT et al. 2019. Neuron. 103(3):412-422 . PubMed
  292. de la Cerda B et al. 2019. Stem cell research. 1726:26:00 . PubMed
  293. Levin E et al. 2019. Cell reports. 26(4):1021-1032 . PubMed
  294. Ribic A et al. 2019. Cell reports. 26(2):381-393 . PubMed
  295. Auboyer L et al. 2019. Stem Cell Res. 1727:38:00 . PubMed
  296. Mura M et al. 2019. Stem Cell Res. 1727:37:00 . PubMed
  297. Herdy J et al. 2019. Elife. 8 pii: e41356. PubMed
  298. Kwart D et al. 2019. Neuron. 104(2):256-270 . PubMed
  299. Corman A et al. 2018. Cell chemical biology. 26(2):235-243 . PubMed
  300. Lavado A et al. 2018. Dev Cell. 47(5):576-591 . PubMed
  301. Lee SG et al. 2018. Stem Cell Res. 31:197-200 . PubMed
  302. Brekk OR et al. 2018. Molecular and cellular neurosciences. 95:1-12 . PubMed
  303. Angelim MKSC et al. 2018. Glia. 66(11):2470-2486 . PubMed
  304. Richard E et al. 2018. Stem cell research. 29:143-147 . PubMed
  305. García‐Peña CM et al. 2018. Frontiers in neuroanatomy. 0.566666667 . PubMed
  306. Mangold CA et al. 2018. J Neurochem. 144(6):723-735 . PubMed
  307. Voronova A et al. 2017. Neuron. 94(3):500-516 . PubMed
  308. Larhammar M et al. 2017. eLife. 6 pii: e20725. PubMed
  309. Kurtenbach S et al. 2017. PloS one. 12(11):e0187576 . PubMed
  310. Wu JS et al. 2017. The Journal of comparative neurology. 526(3):425-438 . PubMed
  311. Walker LJ et al. 2017. eLife. 6 pii: e22540. PubMed
  312. Zhu J et al. 2017. Cell stem cell. 20(3):374-384 . PubMed
  313. Norsworthy MW et al. 2017. Neuron. 94(6):1112-1120 . PubMed
  314. Wu J et al. 2017. Cell. 168(3):473-486 . PubMed
  315. Lin B et al. 2017. Cell stem cell. 21(6):761-774 . PubMed
  316. Kow Essuman et al. 2017. Neuron. 93(6):1334-1343 . PubMed
  317. Abud EM et al. 2017. Neuron. 94(2):278-293 . PubMed
  318. Shao Q et al. 2017. The Journal of Neuroscience. 37(23):5620-5633 . PubMed
  319. Belle M et al. 2017. Cell. 169(1):161-173 . PubMed
  320. Gouti M et al. 2017. Developmental cell. 41(3):243-261 . PubMed
  321. Stratton JA et al. 2017. eNeuro. 4(3) pii: ENEURO. PubMed
  322. Ma S et al. 2017. Developmental cell. 41(4):366-381 . PubMed
  323. Cotton JL et al. 2017. Developmental cell. 43(1):35-47 . PubMed
  324. Huang YA et al. 2017. Cell. 168(3):427-441 . PubMed
  325. Shepherd DJ et al. 2017. Journal of neuropathology and experimental neurology. 76(8):683-696 . PubMed
  326. Varga E et al. 2017. Stem cell research. 25:30-33 . PubMed
  327. Petkovich DA et al. 2017. Cell metabolism. 25(4):954-960 . PubMed
  328. Hansen M et al. 2017. Stem cell research. 25:34-37 . PubMed
  329. Hansen M et al. 2017. Stem cell research. 25:42-45 . PubMed
  330. Hilla AM et al. 2017. The Journal of Neuroscience. 37(25):6113-6124 . PubMed
  331. Ilouz R et al. 2017. eLife. 6 pii: e17681. PubMed
  332. Molotkov A et al. 2017. Developmental cell. 41(5):511-526 . PubMed
  333. Michael Lerche et al. 2017. Structure (London, England : 1993). 25(8):1175-1186 . PubMed
  334. Yu M et al. 2017. Cell research. 27(12):1441-1465 . PubMed
  335. Chen X et al. 2017. Developmental cell. 43(5):563-576 . PubMed
  336. Espuny‐Camacho I et al. 2017. Neuron. 93(5):1066-1081 . PubMed
  337. Sloan SA et al. 2017. Neuron. 95(4):779-790 . PubMed
  338. Leibinger M et al. 2017. Proceedings of the National Academy of Sciences of the United States of America. 114(27):E5454-E5463 . PubMed
  339. Welsbie DS et al. 2017. Neuron. 94(6):1142-1154 . PubMed
  340. Levin E et al. 2017. Scientific reports. 7(1):643 . PubMed
  341. Wang L et al. 2017. The Journal of comparative neurology. 525(13):2915-2928 . PubMed
  342. Sevilla A et al. 2017. Stem Cell Res. 25:217-220 . PubMed
  343. Wang L et al. 2016. The Journal of comparative neurology. 524(11):2322-34 . PubMed
  344. Harrington AJ et al. 2016. eLife. 5 pii: e20059. PubMed
  345. Huh CJ et al. 2016. eLife. 5 pii: e18648. PubMed
  346. Miyake S et al. 2015. Cell death & disease. 6:e1638 . PubMed
  347. Crouch EE et al. 2015. The Journal of Neuroscience. 35(11):4528-39 . PubMed
  348. Nguyen HX et al. 2014. The Journal of comparative neurology. 522(12):2767-83 . PubMed
  349. Ziller MJ, et al. 2018. Cell Stem Cell. 1.304861111. PubMed
  350. Kim YJ, et al. 2018. Neuron. 100:1180. PubMed
  351. Wang XW, et al. 2018. Cell Rep. 24:2540. PubMed
  352. Jung JS, et al. 2019. J Neurosci. 39:6425. PubMed
  353. Tomassoni–Ardori F, et al. 2019. Elife. 8:e46677. PubMed
  354. Wu C, et al. 2019. Cell Rep. 26:1143. PubMed
  355. Bachmann SB, et al. 2019. Cell Rep. 27:3305. PubMed
  356. Kano M, et al. 2019. Endocrinology. 160:1701. PubMed
  357. An D, et al. 2019. Elife. 8:e44423. PubMed
  358. Tsuboi M, et al. 2018. Dev Cell. 47:758. PubMed
  359. Hegarty DM, et al. 2017. J Comp Neurol. 525:2019. PubMed
  360. Weng YL, et al. 2017. Neuron. 94:337. PubMed
  361. Kaplan A, et al. 2017. Neuron. 93:1082. PubMed
  362. Coleman JH, et al. 2017. J Comp Neurol. 525:3391. PubMed
  363. Tozer S, et al. 2017. Neuron. 93:542. PubMed
  364. Liu Z, et al. 2017. Stem Cells Dev. 26:177. PubMed
  365. Ichihara–Tanaka K, et al. 2017. J Histochem Cytochem. 65:513. PubMed
  366. Inoue SI, et al. 2017. Hum Mol Genet. 26:4715. PubMed
  367. Mettang M, et al. 2018. FASEB J. 32:1916. PubMed
  368. Tokuyama MA, et al. 2018. Dev Biol. 433:287. PubMed
  369. Pinheiro H, et al. 2018. Front Pharmacol. 0.527083333. PubMed
  370. Baek C, et al. 2018. PLoS Biol. 16:e2004162. PubMed
  371. Bustos F, et al. 2018. Cell Rep. 2.06875. PubMed
  372. Makdissy N, et al. 2018. Stem Cell Res Ther. 0.466666667. PubMed
  373. Li J, et al. 2018. Neural Plast. 2018:6890613. PubMed
  374. Park JH, et al. 2018. Mol Cell Biol. 38:e00217. PubMed
  375. Hegarty DM, et al. 2018. Pain Rep. 3:e664. PubMed
  376. Syc–Mazurek SB, et al. 2018. Cell Death Dis. 1.135416667. PubMed
  377. Duncan DS, et al. 2018. Front Neurosci. 0.9875. PubMed
  378. Romer–Seibert JS, et al. 2019. FASEB J. 33:3291. PubMed
  379. Bucan V, et al. 2019. Int J Mol Med. 43:593. PubMed
  380. Medeiros CS, et al. 2018. J Refract Surg. 34:790. PubMed
  381. Macova I, et al. 2019. J Neurosci. 39:984. PubMed
  382. Xie Y, et al. 2019. RNA Biol. 0.723611111. PubMed
  383. Maslon MM, et al. 2019. EMBO J. 38:e101244. PubMed
  384. Steevens AR, et al. 2019. Development. 146:dev170522. PubMed
  385. Song Z, et al. 2019. Front Cell Dev Biol. 0.352083333. PubMed
  386. Yang SC, et al. 2019. FASEB J. 33:10577. PubMed
  387. Bonnefont J, et al. 2019. Neuron. 103:1096. PubMed
  388. Teissier A, et al. 2019. Mol Psychiatry. :. PubMed
  389. Wang SE, et al. 2019. Exp Neurobiol. 28:537. PubMed
  390. Ozaki K, et al. 2019. Invest Ophthalmol Vis Sci. 60:4151. PubMed
  391. Arai Y, et al. 2019. Cell Rep. 29:645. PubMed
  392. Valès S, et al. 2019. EBioMedicine. 49:172. PubMed
  393. Pettingill P, et al. 2019. Brain. 142:3852. PubMed
  394. Yang C, et al. 2020. Neuron. 105:276. PubMed
  395. Llères D, et al. 2019. Genome Biol. 1.022222222. PubMed
  396. Yang D, et al. 2019. Elife. 8:e49249. PubMed
  397. Chen YT, et al. 2019. Stem Cell Res Ther. 0.6875. PubMed
  398. Dai WJ, et al. 2019. Evid Based Complement Alternat Med. 2019:8413576. PubMed
  399. Mayanagi T, et al. 2020. Front Cell Neurosci. 0.933333333. PubMed
  400. Ding D, et al. 2020. J Otol. 15:36. PubMed
RRID
AB_2728521 (BioLegend Cat. No. 801213)
AB_2313773 (BioLegend Cat. No. 801201)
AB_10063408 (BioLegend Cat. No. 801202)
Disclaimer

Covered by US patents 5,675,063 and 7,429,487. Sold under license from Epitomics.

Antigen Details

Structure
Tubulin β 3 is a 450 amino acid protein with a molecular mass of ~50 kD.
Distribution

Tissue distribution: central and peripheral nervous system.
Cellular distribution: cytosol, cytoskeleton and nucleus.

Function
Tubulin β 3 is the major constituent of microtubules, and plays a critical role in proper axon guidance and maintenance.
Interaction
Alpha tubulin, kinesin and dynein.
Cell Type
Mature Neurons, Neural Stem Cells
Biology Area
Cell Biology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
Microtubules
Antigen References

1. Zhao X, et al. 2017. Med Sci Monit. 22: 3915.
2. Lebok P, et al. 2016. Oncol Lett. 11(3):1987.
3. Du J, et al. 2015. BMC Cancer. 15:536. PubMed
4. Rogue DM., et al. 2013. Clin Exp Metastasis. 31(1): 101.
5. Ploussard G, et al. 2010. Cancer Res. 70(22):9253. PubMed

Gene ID
10381 View all products for this Gene ID
UniProt
View information about Tubulin beta 3 (TUBB3) on UniProt.org

Related FAQs

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Go To Top Version: 6    Revision Date: 10/24/2019

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