Purified anti-mouse CD365 (Tim-1) Antibody

Pricing & Availability
Clone
3B3 (See other available formats)
Other Names
T cell immunoglobulin and mucin domain containing protein-1, T cell and airway phenotype regulator (Tapr), hepatitic virus cellular receptor 1, CD365
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
3B3_PURE_CD365_Antibody_040616
Mouse Tim-1 transfected cells were stained with purified anti-mouse CD365 (clone 3B3, filled histogram) or purified rat IgG2a, κ isotype control (open histogram), followed by anti-rat IgG PE.
  • 3B3_PURE_CD365_Antibody_040616
    Mouse Tim-1 transfected cells were stained with purified anti-mouse CD365 (clone 3B3, filled histogram) or purified rat IgG2a, κ isotype control (open histogram), followed by anti-rat IgG PE.
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151702 100 µg 144€
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Description

CD365 (Tim-1) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-1 and hepatitis virus cellular receptor 1. It is developmentally expressed at high levels in the blastocyst. Tim-1 is expressed on activated CD4+ lymphocytes especially on Th2 cells and has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in costimulation of T cell proliferation. Tim-1 is an endogenous ligand for LMIR5/CD300b.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant mouse TIM-1 (igV domain) FC chimera IFA
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Direct ELISA - Reported in the literature

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.75 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2616785 (BioLegend Cat. No. 151702)

Antigen Details

Structure
Transmembrane protein containing immunoglobulin domain and mucin-like domain with the predicted molecular weight of 33 kD.
Distribution
Developmentally regulated; highly expressed in embryonic development in blastocysts. Expressed on activated CD4+ lymphocytes, especially Th2 cell lines.
Function
Binds hepatitis virus, may play a critical role in immune responses and the development of atopic diseases (in particular airway hyperreactivity).
Ligand/Receptor
Binds hepatitis A virus in humans, Tim-4, and LMIR5/CD300b.
Biology Area
Cell Biology, Cell Proliferation and Viability, Immunology
Molecular Family
CD Molecules, TCRs
Antigen References

1. McIntire JJ, et al. 2001. Nat. Immunol. 2:1109.
2. Kuchroo VK, et al. 2003. Nat. Rev. Immunol. 3:454.
3. Wills-Karp M, et al. 2001. Nat. Rev. Immunol. 1:69.
4. Meyers JH, et al. 2005. Nat. Immunol. 6(5):455.
5. Umetsu S, et al. 2005. Nat. Immunol. 6:447.
6. Lee HH, et al. 2010. J. Immunol. 185:5225.

Gene ID
171283 View all products for this Gene ID
UniProt
View information about CD365 on UniProt.org

Related FAQs

There are no FAQs for this product.
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For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

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