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- Clone
- 53a.2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Integrin alpha V beta 6
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Human colon carcinoma cell line (HT29) stained with purified anti-human Integrin αVβ6 (clone 53a.2) (filled histogram), or rat IgG2a, κ isotype control (open histogram) followed by PE goat anti-rat IgG.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 384202 | 100 µg | 308€ | ||||
Integrins are heterodimeric transmembrane receptors comprising alpha and beta subunits that function as cell anchoring and signaling molecules. The ITGAV gene encodes integrin alpha V, a type I integral membrane glycoprotein known as the vitronectin receptor α chain, or CD51. It forms a heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. Integrin αV contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Integrin beta 6 is a protein that in humans is encoded by the ITGB6 gene. The β6 subunit only combines with αV to generate a single heterodimer. Integrin αVβ6 is a subtype of the integrin family expressed exclusively on epithelial cells. Integrin αVβ6 is usually expressed at low or undetectable levels in normal adult tissues but can be highly upregulated during pathological and physiological processes such as wound healing, fibrosis, inflammation, and cancer.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
ICC, IP - Reported in the literature, not verified in house - Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
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- Marsh D, el al. 2008. Cancer Res. 68:3295.
- RRID
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AB_2927857 (BioLegend Cat. No. 384202)
Antigen Details
- Distribution
-
Epithelial cells
- Function
- Modulate innate immune surveillance, maintain epithelial stem cell quiescence
- Ligand/Receptor
- Serve as a fibronectin receptor
- Cell Type
- Epithelial cells
- Biology Area
- Angiogenesis, Cell Adhesion
- Molecular Family
- Adhesion Molecules
- Gene ID
- 3685 View all products for this Gene ID 3694 View all products for this Gene ID
- UniProt
- View information about Integrin alphaVbeta6 on UniProt.org
Related FAQs
Other Formats
View All Integrin αVβ6 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human Integrin αVβ6 | 53a.2 | FC,ICC,IP |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human Integrin αVβ6
Human colon carcinoma cell line (HT29) stained with purified...
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