- Clone
- SA214G2 (See other available formats)
- Other Names
- CDw198, C-C chemokine receptor type 8, CKR-8, CC-CKR-8, Ter1
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 mouse thymocytes were stained with CD4 FITC and CD198 (CCR8) (clone SA214G2) APC (top) or rat IgG2b, κ APC isotype control (bottom). -
| Cat # | Size | Price | Quantity Avail. | Save | ||
|---|---|---|---|---|---|---|
| 150309 | 25 µg | 100€ | ||||
| 150310 | 100 µg | 260€ | ||||
C-C chemokine receptor type 8 (CCR8) CD198, is a 41 kD G-protein coupled receptor with 7 transmembrane regions. CCR8 is expressed by a subset of thymocytes, Tregs, NKT and Th2-polarized cells, a subset of macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 mediates chemotaxis toward its ligand CCL1, and is involved in apoptosis of thymocytes.
Product DetailsProduct Details
- Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse CD198 (CCR8)-transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Red Laser (633 nm)
- RRID
-
AB_2629601 (BioLegend Cat. No. 150309)
AB_2629602 (BioLegend Cat. No. 150310)
Antigen Details
- Structure
- G-protein coupled receptor, 7 transmembrane regions, 41 kD.
- Distribution
-
Thymocytes, Tregs, NKT and Th2-polarized cells, subset of macrophages, monocytes and monocyte-derived dendritic cells.
- Function
- Chemotaxis, involved in thymocyte apoptosis
- Ligand/Receptor
- CCL1 (SCY1,TCA-3)
- Cell Type
- Dendritic cells, Macrophages, Monocytes, NKT cells, Th2, Thymocytes, Tregs
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
-
1. Coghill JM, et al. 2013. Blood. 122:825.
2. Islam SA, et al. 2011. Nat. Immunol. 12:167.
3. Hoshino A, et al. 2007. J. Immunol. 178:5296.
3. Qu C, et al. 2004. J. Exp. Med. 200:1231. - Gene ID
- 12776 View all products for this Gene ID
- UniProt
- View information about CD198 on UniProt.org
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