- S20020H (See other available formats)
- Regulatory Status
- Other Names
- S152, T14, TNFRSF7
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
CD27 is a 50-55 kD type I membrane protein also known as S152 and T14. It is a lymphocyte-specific member of the TNF-receptor superfamily. CD27 is expressed on medullary thymocytes, virtually all mature T cells, some B cells, and NK cells. CD27 binds to CD70 and plays an important role in costimulation of T cell activation, and regulation of B cell differentiation and proliferation. The cytoplasmic domains of CD27 have also been shown to interact with TRAF2 and TRAF5 to elicit NF-κB and SAPK/JNK activation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Hu CD27 transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone S20020H does not block binding of clones M-T271, O323, or S20020G on target cells.
Clone S20020H can block binding between CD27 and CD70 (CD27L).
AB_2927931 (BioLegend Cat. No. 385002)
- TNF-R superfamily, type I transmembrane glycoprotein, 50-55 kD
Medullary thymocytes, T and B cell subsets, NK cells
- T cell costimulation
- TRAF2, TRAF5
- Cell Type
- B cells, Lymphocytes, NK cells, T cells
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
- Camerini D, et al. 1991. J Immunol. 147:3156-60.
- Hintzen R, et al. 1994. Immunol Today. 15:307-11.
- Gene ID
- 939 View all products for this Gene ID
- View information about CD27 on UniProt.org
|Purified anti-human CD27||S20020H||FC|
|FITC anti-human CD27||S20020H||FC|
|PE anti-human CD27||S20020H||FC|
|APC anti-human CD27||S20020H||FC|
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