PE anti-human CD182 (CXCR2) Antibody

Pricing & Availability
5E8/CXCR2 (See other available formats)
Regulatory Status
Other Names
CD182, CXCR2, CD128b, IL-8RB, Type II IL-8 receptor
Mouse IgG1, κ
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Product Citations
Human peripheral blood granulocytes stained with 5E8/CXCR2 PE
  • 5E8slash-CXCR2-PE_111605
    Human peripheral blood granulocytes stained with 5E8/CXCR2 PE
Compare all formats See PE spectral data
Cat # Size Price Save
320705 25 tests ¥26,840
320706 100 tests ¥58,960

CXCR2 is a 67-70 kD seven-transmembrane protein, also known as IL-8 receptor B (IL-8RB), CD182, and CD128b. It is a CXC chemokine receptor belongs to G protein-coupled receptor (GPCR) family. CXCR2 is expressed as homodimer or heterodimer with CXCR1 and found on granulocytes, NK cells, subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. CXCR2 mediates neutrophil activation and chemotaxis, megakaryocytic proliferation, and angiogenesis via binding its ligands including IL-8(CXCL8), NAP-2(CXCL7), GCP-2(CXCL6), and GRO-α,β,γ (CXCL1, CXCL2, CXCL3).

Product Details
Technical data sheet

Product Details

Verified Reactivity
Antibody Type
Host Species
Human CXCR2 transfected L1.2 cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: The 5E8/CXCR2 antibody is useful for immunofluorescent staining and flow cytometric analysis of CXCR2 expression.

Application References

(PubMed link indicates BioLegend citation)
  1. Kyriakakis E, et al. 2011. J Leukoc Biol. 90:929. PubMed.
Product Citations
  1. Perrigue P, et al. 2015. Mol Cancer Res. 13:636. PubMed
  2. Malekghasemi S, et al. 2020. Cell Biol Int. 44:2031. PubMed
  3. Mandl M, et al. 2014. PLoS One. 9:112140. PubMed
  4. Whilding LM, et al. 2019. Cancers (Basel). 11:5. PubMed
  5. Yin S, et al. 2015. Sci Rep. 5: 14432. PubMed
  6. Collins PL et al. 2018. Cell. 176(1-2):348-360 . PubMed
  7. Walle T, et al. 2022. Sci Adv. 8:eabh4050. PubMed
  8. Tian Z, et al. 2022. Cancer Cell Int. 22:362. PubMed
AB_439806 (BioLegend Cat. No. 320705)
AB_439807 (BioLegend Cat. No. 320706)

Antigen Details

Seven transmembrane spanning, G protein-coupled receptor (CPCR), 67-70 kD, homodier or teterodimer with CXCR1

Granulocytes, NK cells, subset of T cells, monocytes, endothelial cells, oligodendrocytes

Neutrophil activation, chemotaxis, angiogenesis
IL-8(CXCL8), NAP-2(CXCL7), GCP-2(CXCL6), GRO-& alpha;,ß, γ (CXCL1, CXCL2, CXCL3)
Cell Type
Granulocytes, NK cells, T cells, Monocytes, Endothelial cells, Oligodendrocytes, Neutrophils
Biology Area
Angiogenesis, Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Chuntharapai A, et al. 1994. J. Immunol. 153:5682.
2. Wilson S, et al. 2005. J. Biol. Chem. 280:28663.
3. Emadi S, et al. 2005. Blood 105:464.
4. Omari KM, et al. 2005. Brain 128:1003.
5. Juremalm M and Nilsson G. 2005. Chem. Immunol. Allergy 87:130.
6. Wolf M, et al. 1998. Eur. J. Immunol. 28:164.

Gene ID
3579 View all products for this Gene ID
View information about CD182 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Does staining at room temperature or even at 37°C help for checking chemokine receptors expression?

Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal.

Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.


This product is supplied subject to the terms and conditions, including the limited license, located at ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.


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