Adhesion Molecules


Cell adhesion molecules (CAMs) belong to four different families: immunoglobulin (Ig) superfamily, integrins, cadherins, and selectins. CAMs mediate cell-to-cell and/or cell-to-extracellular matrix (ECM) interactions that can be either adhesive or inhibitory in nature. These interactions can also be associated with changes in downstream signaling pathways, cytoskeletal reorganization, or gene expression.


View our recombinant adhesion molecules.


Enzymes and Regulators


Enzymes act as biological catalysts to regulate chemical reactions and are highly specific to the substrates with which they react. Through these reactions, enzymes and their regulators modulate cell fate, localization, and activity of many proteins. Enzymes also regulate protein-protein interactions, create new bioactive molecules, and contribute to signal transduction. Through these actions, enzymes influence cellular functions such as proliferation, differentiation, DNA replication, inflammation, and apoptosis.


View our recombinant enzymes.





Soluble Receptors


Receptors bind to their respective ligands and recognize and respond to cell signals. They are a broad group which includes signaling receptors, non-signaling decoy receptors, receptor-associated proteins, and soluble receptors. Naturally occurring soluble receptors can be generated by several mechanisms, including proteolytic cleavage of surface-bound receptor ectodomains, alternative splicing of mRNA transcripts, transcription of distinct genes, cleavage of GPI-anchored receptors, and extracellular release of membrane-bound receptors within vesicles of exosomes.


One example is soluble cytokine receptors which once bound to cytokines can act as either agonists or antagonists of cytokine signaling. Our recombinant soluble receptors are constructed to encode only the extracellular domain and do not include the transmembrane or cytoplasmic domains.


View our recombinant soluble receptors.





Other Recombinant Proteins


In addition to the groups of proteins already described, we have many other recombinant proteins that can be used in a variety of bioassays. These proteins also play important cellular roles including cell migration, survival, regulation of immune responses, apoptosis, neuroinflammation, Alzheimer’s disease, tumor cell phenotypes, and autoimmune diseases.


View our other recombinant proteins.



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