- 27-9 (See other available formats)
- Regulatory Status
- Other Names
- Junctional adhesion molecule-1,Jam-1, Jam-A, junctional adhesion molecule-A, CD321
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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F11R is a cell adhesion molecule and immunoglobulin superfamily member and an important regulator of tight junction assembly in epithelia. It is found on the surface of platelets, and plays a role in platelet aggregation, secretion, adhesion, and spreading. By interacting with integrin alpha-L/beta-2, it is involved in leukocyte transmigration.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- E14.5 mouse fetal liver cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-F - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.5 µg per million cells in 100 µL volume. For immunohistochemistry, a concentration range of 2.0 - 5.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
- Sugano Y et al. 2008. Blood. 111(3): 1167–72.
AB_2904280 (BioLegend Cat. No. 107802)
- 32 kD single pass type I membrane glycoprotein, member of the immunoglobin superfamily
Cell membrane, tight junctions
- Protein homodimerization, integrin binding, PDZ domain binding, tight junction formation
- integrin alpha-L/beta-2, MPDZ, PARD3, ITGAL
- integrin alpha-L/beta-2
- Cell Type
- Endothelial cells, Epithelial cells, Leukocytes, Platelets
- Biology Area
- Angiogenesis, Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
- Martin-Padura I, et al. 1998. J. Cell Biol. 142:117-27.
- Muller W.A. 2003. Trends Immunol. 24:327-34.
- Kostrewa D., et al. 2001. EMBO J. 20:4391-8.
- Gene ID
- O88792 View all products for this Gene ID
- View information about CD321 on UniProt.org
|Purified anti-mouse CD321 (F11R)||27-9||FC, IHC-F|
|PE anti-mouse CD321 (F11R)||27-9||FC|
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