CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser
Red Laser (633 nm)
Application Notes
Clone Bu15 has a different binding epitope than clone 3.9. The binding of Bu15 with CD11c is divalent cation independent. Additional reported applications (for the relevant formats of this clone) include: inhibition of CD11c mediated adhesion and stimulation of chemokine production by monocytes.
Application References
Sadhu C, et al. 2008. J. Immunoass. Immunoch. 29:42.
Rezzonico R, et al. 2001. Blood 97:2932.
Sadhu C, et al. 2007. J. Leukoc. Biol. 81:1395.
Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
Product Citations
Hunn M, et al. 2012. Clin Cancer Res. 18:6446. PubMed
Halim TYF et al. 2018. Immunity. 48(6):1195-1207 . PubMed
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