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Purified anti-human CD11c Antibody

Pricing & Availability
Clone
Bu15 (See other available formats)
Regulatory Status
RUO
Workshop
V S143
Other Names
Integrin αx subunit, ITGAX, CR4, p150
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
Bu15_Pure_110308.jpg
Human peripheral blood granulocytes stained with purified Bu15, followed by anti-mouse IgG FITC
  • Bu15_Pure_110308.jpg
    Human peripheral blood granulocytes stained with purified Bu15, followed by anti-mouse IgG FITC
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337202 100 µg 90€
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Description

CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
CyTOF® - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone Bu15 has a different binding epitope than clone 3.9. The binding of Bu15 with CD11c is divalent cation independent. Additional reported applications (for the relevant formats of this clone) include: inhibition of CD11c mediated adhesion and stimulation of chemokine production by monocytes.

Application References
  1. Sadhu C, et al. 2008. J. Immunoass. Immunoch. 29:42.
  2. Rezzonico R, et al. 2001. Blood 97:2932.
  3. Sadhu C, et al. 2007. J. Leukoc. Biol. 81:1395.
  4. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
Product Citations
  1. Martin–Fernandez M, et al. 2020. Cell Reports. 31(6):107633. PubMed
  2. Taft J, et al. 2021. Cell. 184(17):4447-4463.e20. PubMed
  3. Cao Q, et al. 2018. Am J Physiol Renal Physiol. 314:F561. PubMed
  4. Mann ER, et al. 2020. Sci Immunol. :5. PubMed
  5. Yang R, et al. 2020. Cell. 183(7):1826-1847.e31. PubMed
  6. Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed
  7. Gruber CN, et al. 2020. Cell. 183:982. PubMed
  8. Wastyk HC, et al. 2021. Cell. 184(16):4137-4153.e14. PubMed
  9. Henrick BM, et al. 2021. Cell. . PubMed
  10. Newell KL, et al. 2021. PLoS One. 16:e0244855. PubMed
  11. NULL, et al. 2022. Cell. 185:916. PubMed
  12. Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
  13. Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
RRID
AB_1236381 (BioLegend Cat. No. 337202)

Antigen Details

Structure
Integrin, type I transmembrane glycoprotein, associates with integrin β2 (CD18), 145-150 kD
Distribution

Myeloid, dendritic cells, NK cells, B cells and T cell subsets

Function
Adhesion, CTL killing Ligand Receptor: CD54, fibrinogen, iC3b, ICAM-1, ICAM-4 Antigen
Cell Type
B cells, Dendritic cells, Neutrophils, NK cells, T cells
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Petty H. 1996. Immunol. Today 17:209.
2. Springer T. 1994. Cell 76:301.
3. Ihanus E, et al. 2007. Blood 109:802-810.

Gene ID
3687 View all products for this Gene ID
UniProt
View information about CD11c on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 02/14/2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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