Purified anti-Tubulin β 3 (TUBB3) Antibody (Previously Covance catalog# MMS-435P)

Pricing & Availability
Clone
TUJ1 (See other available formats)
Regulatory Status
RUO
Other Names
CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, Tubulin beta-3 chain, tubulin beta-III, tubulin beta-4 chain, class III beta-tubulin
Previously
Covance Catalog# MMS-435P
Isotype
Mouse IgG2a, κ
Ave. Rating
Submit a Review
Product Citations
publications
A_TUJ1_PURE_Tubulin-beta3_IHCP_Hu_011618
IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded human brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • A_TUJ1_PURE_Tubulin-beta3_IHCP_Hu_011618
    IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded human brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 1 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • B_TUJ1_PURE_Tubulin-beta3_IHCP_Rat_011618
    IHC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on formalin-fixed paraffin-embedded rat brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 0.5 µg/mL of the primary antibody overnight at 4°C. BioLegend’s Ultra Streptavidin (USA) HRP Detection Kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
  • C_TUJ1_PURE_Tubulin-beta3_WB_011618
    Western blot of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of Mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blots were incubated with 1 ug/mL of TUJ1 or mouse IgG overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • D_TUJ1_PURE_Tubulin-beta3_ICC_011618
    ICC staining of purified anti-Tubulin β 3 (TUBB3) antibody (clone TUJ1) on SH-SY5Y neuroblastoma cells. The cells were fixed by 4% PFA, permeabilized with a buffer containing 0.1% Triton X-100 and 0.25% BSA, and blocked with 2% Normal Goat Serum and 0.02% BSA. The cells were then incubated with 1 µg/mL of the primary antibody for 3 hours at room temperature, followed by incubation with 0.5 µg/mL Alexa Fluor® 594 goat anti-mouse IgG (Cat. No. 405326) for 1 hour at room temperature. Nuclei were counterstained with DAPI. The image was captured with a 60X objective Scale bar: 20 µm
  • E_Ankita_Patil
    Methanol fixed superior cervical ganglion neurons were stained with anti-tubulin β3 (pink) and anti-TRIM46 (aqua), then stained with secondary antibodies, phalloidin (orange) and DAPI (blue). Image generously submitted to the 2017 Cell Life Imaging Competition by Ankita Patil from Drexel University.
Compare all formats
Cat # Size Price Quantity Check Availability Save
801213 25 µL 85€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
801201 100 µL 212€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
801202 250 µL 313€
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

Tubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors. Studies indicate that it is a predictive and prognostic marker in various tumors.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This antibody was raised against microtubules derived from rat brain.
Formulation
Phosphate-buffered solution + 0.03% Thimerosal.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1.0 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

IHC-P - Quality tested
WB, ICC - Verified
FC - Reported in the literature, not verified in house
SB - Community verified

Recommended Usage

Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 5.0 µg/ml is suggested. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg/ml. For immunocytochemistry, a concentration range of 1.0 - 5.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: flow cytometry4, immunofluorescence microscopy1-5,7, immunohistochemistry5,7, Western blotting8, and spatial biology (IBEX)9,10.

This antibody is well characterized and highly reactive to neuron specific Class III ß-tubulin (ßIII). TUJ1 does not identify ß-tubulin found in glial cells. TUJ1 recognizes an epitope located within the last 15 C-terminal residues8.

Additional Product Notes

This product has been verified for IHC-F (Immunohistochemistry - frozen tissue sections) on the NanoString GeoMx® Digital Spatial Profiler. The GeoMx® enables researchers to perform spatial analysis of protein and RNA targets in FFPE and fresh frozen human and mouse samples. For more information about our spatial biology products and the GeoMx® platform, please visit our spatial biology page.

Application References

(PubMed link indicates BioLegend citation)
  1. Nishimura K, et al. 2017. PLoS One. 12(1): e0170568. (ICC)
  2. Jongbloets J, et al. 2017. Nat Commun. 8: 14666. (ICC) PubMed
  3. Liu W.J, et al. 2015. Eur J Histochem. 59(1): 2464. (ICC) PubMed
  4. Chintalapudi SR, et al. 2016. Front Aging Neursci. 8:93. (FC, ICC) PubMed
  5. Ambasudhan R, et al. 2011. Cell Stem Cell. 9(2):113. (IHC, ICC)
  6. Hu X., et al. 2006. Nature Neuroscicene. 9(12):1520. (WB) PubMed
  7. Zechner D., et al. 2003. Develop Biology. 258(2):406. (ICC, IHC)
  8. Lee MK, et al. 1990. Proc. Natl. Acad. Sci. USA 18:7195. (WB)
  9. Radtke AJ, et al. 2020. Proc Natl Acad Sci USA. 117:33455-33465. (SB) PubMed
  10. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Birsa N, et al. 2021. Sci Adv. 7: . PubMed
  2. Castelli LM, et al. 2021. Mol Neurodegener. 16:53. PubMed
  3. Nakayama T, et al. 2021. Cell Rep Med. 2:100421. PubMed
  4. Ye M, et al. 2021. Cell Death Dis. 12:1149. PubMed
  5. Seebauer L, et al. 2022. Int J Mol Sci. 23:. PubMed
  6. Zainul Z, et al. 2022. Sci Rep. 12:3344. PubMed
  7. Ahangari N, et al. 2021. J Neuropathol Exp Neurol. 80:944. PubMed
  8. Dang LT, et al. 2021. Dev Neurobiol. 81:696. PubMed
  9. Tsefou E, et al. 2021. Biochem J. 478:4099. PubMed
  10. Jacquier A, et al. 2022. Acta Neuropathol. 144:707. PubMed
  11. Wang Z, et al. 2022. Research (Wash D C). 2022:9832128. PubMed
  12. Schroeter MS, et al. 2022. MRS Bull. 47:530. PubMed
  13. Lee J, et al. 2022. Nat Protoc. 17:1266. PubMed
  14. Gai M, et al. 2016. EMBO Rep. 17: 1396 - 1409. PubMed
  15. Nonomura K, et al. 2016. Nature. 541:176-181. PubMed
  16. Ueki J, et al. 2017. Sci Rep. 7:42522. PubMed
  17. Fernandes HJR, et al. 2020. Cell Rep. 33:108263. PubMed
  18. Ko KW, et al. 2020. J Cell Biol. 219:00:00. PubMed
  19. Tilak M, et al. 2021. Molecular Cancer Research. 19(5):757-770. PubMed
  20. Alonso-Barroso E, et al. 2017. Stem Cell Research. 23:173-177. PubMed
  21. Wang YL, et al. 2021. Cell Reports. 36(8):109537. PubMed
  22. Tristan CA, et al. 2020. bioRxiv. . PubMed
  23. Abey A, et al. 2020. Brain Pathol. 31:144. PubMed
  24. Boyer NP, et al. 2018. Eneuro. 55:1847. PubMed
  25. Lee SW et al. 2018. Developmental cell. 46(1):73-84 . PubMed
  26. Chia PH et al. 2018. eLife. 7 pii: e32451. PubMed
  27. Erwig MS, et al. 2019. Elife. 8:. PubMed
  28. Tohgi N, et al. 2017. Cell Cycle. 16:95. PubMed
  29. Nicole O, et al. 2018. Mol Psychiatry. 23:2209. PubMed
  30. Kirihara T, et al. 2019. iScience. 14:301. PubMed
  31. Sanli I, et al. 2018. Cell Rep. 23:337. PubMed
  32. Croteau LP, et al. 2019. Sci Rep. 9:12009. PubMed
  33. Ioannou MS et al. 2019. Cell. 177(6):1522-1535 . PubMed
  34. Paonessa F et al. 2019. Cell reports. 26(3):582-593 . PubMed
  35. de la Cerda B et al. 2019. Stem cell research. 1726:26:00 . PubMed
  36. García‐Peña CM et al. 2018. Frontiers in neuroanatomy. 0.566666667 . PubMed
  37. Coleman JH, et al. 2017. J Comp Neurol. 525:3391. PubMed
  38. Abud EM et al. 2017. Neuron. 94(2):278-293 . PubMed
  39. Huang YA et al. 2017. Cell. 168(3):427-441 . PubMed
  40. Hegarty DM, et al. 2018. Pain Rep. 3:e664. PubMed
  41. Dai WJ, et al. 2019. Evid Based Complement Alternat Med. 2019:8413576. PubMed
  42. Wang XW, et al. 2020. Cell Rep. 31:107537. PubMed
  43. Woeste MA, et al. 2019. J Biol Chem. 294:3853. PubMed
  44. Tian R, et al. 2019. Neuron. 104:239. PubMed
  45. Babetto E, et al. 2020. Nat Neurosci. 23:1215. PubMed
  46. Eltahir MK, et al. 2022. PLoS One. 17:e0269683. PubMed
  47. Simoes S, et al. 2021. Cell Rep. 37:110182. PubMed
  48. Viais R, et al. 2021. Elife. 10:. PubMed
  49. Lafarga V, et al. 2021. EMBO J. 40:e103311. PubMed
  50. Kim S, et al. 2021. Nat Commun. 12:1807. PubMed
  51. Brown AL, et al. 2022. Nature. 603:131. PubMed
  52. Ruden JB, et al. 2021. Front Mol Neurosci. 14:777049. PubMed
  53. Tseng JH, et al. 2021. Cell Rep. 35:109037. PubMed
  54. Guo B, et al. 2021. Front Cell Dev Biol. 9:768970. PubMed
  55. Li F, et al. 2021. Nat Commun. 12:3845. PubMed
  56. Xia F, et al. 2021. Acta Neuropathol Commun. 51:9. PubMed
  57. Shin BC, et al. 2021. Experimental Neurology. 338:113603. PubMed
  58. Wang D, et al. 2020. Journal of Biological Chemistry. 295(25):8374-8386. PubMed
  59. Khoa LTP, et al. 2020. Cell Stem Cell. 27(3):441-458.e10. PubMed
  60. Domènech EB, et al. 2020. Invest Ophthalmol Vis Sci. 61:14:00. PubMed
  61. Elhardt C, et al. 2020. Transl Vis Sci Technol. 9:06. PubMed
  62. Lee SE, et al. 2020. Cell Death Dis. 1.19375. PubMed
  63. Orozco-Díaz R, et al. 2019. PLoS One. 14:e0220393. PubMed
  64. Arber C, et al. 2019. Brain Commun. 1:fcz024. PubMed
  65. Valès S, et al. 2019. EBioMedicine. 49:172. PubMed
  66. Teissier A, et al. 2019. Mol Psychiatry. :. PubMed
  67. Macova I, et al. 2019. J Neurosci. 39:984. PubMed
  68. Inoue SI, et al. 2017. Hum Mol Genet. 26:4715. PubMed
  69. Shepherd DJ et al. 2017. Journal of neuropathology and experimental neurology. 76(8):683-696 . PubMed
  70. Kow Essuman et al. 2017. Neuron. 93(6):1334-1343 . PubMed
  71. Mangold CA et al. 2018. J Neurochem. 144(6):723-735 . PubMed
  72. Levin E et al. 2019. Cell reports. 26(4):1021-1032 . PubMed
  73. Murcia-Belmonte V, et al. 2019. Curr Biol. 29:1149. PubMed
  74. Daoutsali E et al. 2019. Stem Cell Res. 1723:19:00 . PubMed
  75. Ogawa Y et al. 2019. Neurosci Res. pii: S0168-0102(19)30120-8 . PubMed
  76. Tiethof AK, et al. 2018. Toxics. 6:52. PubMed
  77. Boso D, et al. 2019. Theranostics. 9:4860. PubMed
  78. Cha HL, et al. 2019. Mol Brain. 12:57. PubMed
  79. Wang G et al. 2019. eLife. 8 pii: e38730. PubMed
  80. Vinci M, et al. 2018. Nat Med. 24:1204. PubMed
  81. Laussu J, et al. 2017. Neural Dev. 12:10. PubMed
  82. Hu X, et al. 2019. Stem Cell Reports. 12:290. PubMed
  83. Valadas JS et al. 2018. Neuron. 98(6):1155-1169 . PubMed
  84. Ziller MJ, et al. 2018. Cell Stem Cell. 1.304861111. PubMed
  85. Park SY, et al. 2018. Mol Brain. 169:91. PubMed
  86. Yun T, et al. 2021. Cell Death Discov. 7:257. PubMed
  87. Herbst WA, et al. 2021. J Cell Biol. 220:. PubMed
  88. Heinrich A, et al. 2021. Cell Rep. 37:109885. PubMed
  89. Earley AM, et al. 2021. Sci Rep. 11:22257. PubMed
  90. Ramirez S, et al. 2021. STAR Protoc. 2:100987. PubMed
  91. Valenzuela M, et al. 2022. Stem Cell Res Ther. 13:261. PubMed
  92. Richardson RT, et al. 2021. Sci Rep. 11:11229. PubMed
  93. Guo X, et al. 2021. Cell. 184:4299. PubMed
  94. Vilallongue N, et al. 2022. Nat Commun. 13:6040. PubMed
  95. Kishi N, et al. 2016. Nat Commun. 7:10520. PubMed
  96. Nawaz M, et al. 2016. PLoS One. 11: 0148634. PubMed
  97. Tao W, et al. 2020. EMBO Mol Med. 12:e12291. PubMed
  98. Bae B, et al. 2020. RNA. 26:1414. PubMed
  99. Halikere A, et al. 2020. Mol Psychiatry. 25:1406. PubMed
  100. Song JM, et al. 2021. The Journal of Neuroscience. 41(11):2344-2359. PubMed
  101. Benito-Kwiecinski S, et al. 2021. Cell. 184(8):2084-2102.e19. PubMed
  102. Bayerl J, et al. 2021. Cell Stem Cell. . PubMed
  103. Eriksen AZ, et al. 2021. Cell Stem Cell. 28(7):1205-1220.e7. PubMed
  104. Elsayed AK, et al. 2021. Stem Cell Research. 54:102433. PubMed
  105. Lpez-Mrquez A, et al. 2019. Stem Cell Research. 38:101469. PubMed
  106. Sood S, et al. 2020. Proc Natl Acad Sci U S A. 22331:117. PubMed
  107. Lim SH, et al. 2020. J Cell Sci. :133. PubMed
  108. Coste C, et al. 2017. PLoS One. 10.1371/journal.pone.0177962. PubMed
  109. Miranda AM, et al. 2018. Nat Commun. 9:291. PubMed
  110. Liu C, et al. 2018. Stem Cell Reports. 4:43. PubMed
  111. Lee SY et al. 2018. Stem cell research. 30:145-149 . PubMed
  112. Vitali I et al. 2018. Cell. 174(5):1264-1276 . PubMed
  113. Roselló-Busquets C, et al. 2019. Front Cell Neurosci. 13:40. PubMed
  114. Stepp MA, et al. 2018. Int J Mol Sci. 19:12. PubMed
  115. Miltner AM, et al. 2019. Int J Mol Sci. 20. PubMed
  116. Canali G, et al. 2018. Hum Mol Genet. 27:1941. PubMed
  117. Haverfield JT, et al. 2017. Reprod Fertil Dev. 29:609. PubMed
  118. Arellano‐Viera E et al. 2019. Stem cell research. 1726:10:00 . PubMed
  119. Ribic A et al. 2019. Cell reports. 26(2):381-393 . PubMed
  120. Varga E et al. 2017. Stem cell research. 25:30-33 . PubMed
  121. Nguyen HX et al. 2014. The Journal of comparative neurology. 522(12):2767-83 . PubMed
  122. Bonnefont J, et al. 2019. Neuron. 103:1096. PubMed
  123. Giandomenico SL, et al. 2019. Nat Neurosci. 22:669. PubMed
  124. Stratton JA, et al. 2020. Front Aging Neurosci. 0.620833333. PubMed
  125. Masumoto K, et al. 2022. Sci Rep. 12:10351. PubMed
  126. McClellan S, et al. 2021. Invest Ophthalmol Vis Sci. 62:14. PubMed
  127. Hagihara H, et al. 2021. Cell Rep. 37:109820. PubMed
  128. Boussaad I, et al. 2021. Sci Rep. 11:1439. PubMed
  129. Savino E, et al. 2021. Cells. 10:. PubMed
  130. Liu X, et al. 2021. Cell Prolif. 54:e13124. PubMed
  131. Doron-Mandel E, et al. 2021. EMBO J. 40:e107158. PubMed
  132. Lennox AL, et al. 2020. Neuron. 404:106. PubMed
  133. Pecori F, et al. 2021. Cell Reports. 36(2):109361. PubMed
  134. Aarts CEM, et al. 2021. Stem Cell Research. 54:102444. PubMed
  135. Zhang K, et al. 2021. Neuron. 109(12):1949-1962.e6. PubMed
  136. Aprigliano R, et al. 2021. Cell Reports Medicine. 2(4):100240. PubMed
  137. Pantier R, et al. 2021. Molecular Cell. 81(4):845-858.e8. PubMed
  138. Parlanti P, et al. 2020. Exp Eye Res. 194:107998. PubMed
  139. Toma JS, et al. 2020. Eneuro. 7:00. PubMed
  140. Solis-Castro OO, et al. 2020. Stem Cells Transl Med. 1.390277778. PubMed
  141. Ucuncu E, et al. 2020. Nat Commun. 4.685416667. PubMed
  142. LI Y, et al. 2017. Proc Natl Acad Sci U S A. 114(2):E209-E218. PubMed
  143. Jiang G, et al. 2016. Stem Cells Trans Med. 5(12):1595-1606. PubMed
  144. Martin C, et al. 2016. Genes Dev. 30: 2158 - 2172. PubMed
  145. Kida H, et al. 2016. Cereb Cortex. 10.1093/cercor/bhw134. PubMed
  146. Savino E, et al. 2020. Cell Death Dis. 1.052777778. PubMed
  147. Saito K, et al. 2019. Cell Rep. 29:1555. PubMed
  148. Lilian SJ, et al. 2019. J Assoc Res Otolaryngol. 20:133. PubMed
  149. Milbreta U, et al. 2019. Mol Ther. 27:411. PubMed
  150. Arai Y, et al. 2019. Cell Rep. 29:645. PubMed
  151. Bucan V, et al. 2019. Int J Mol Med. 43:593. PubMed
  152. Petkovich DA et al. 2017. Cell metabolism. 25(4):954-960 . PubMed
  153. Auboyer L et al. 2019. Stem Cell Res. 1727:38:00 . PubMed
  154. Tomassoni–Ardori F, et al. 2019. Elife. 8:e46677. PubMed
  155. Van Der Raadt J, et al. 2019. Nucleic Acids Res. 47:5587. PubMed
  156. Raspa A, et al. 2019. CNS Neurosci Ther. 25:86. PubMed
  157. González C, et al. 2018. Mol Psychiatry. 23:2363. PubMed
  158. Liu H, et al. 2019. Front Cell Neurosci. 13:60. PubMed
  159. Mura M et al. 2018. Stem cell research. 29:170-173 . PubMed
  160. Hermanto Y et al. 2018. Journal of neuroscience research. 96(5):863-874 . PubMed
  161. Playne R, et al. 2018. J Stem Cells Regen Med. 7:e36998. PubMed
  162. Allende ML, et al. 2018. J Lipid Res. 59:550. PubMed
  163. Iwasa N, et al. 2021. Front Cell Neurosci. 15:605030. PubMed
  164. Boshans LL, et al. 2021. Sci Rep. 11:3552. PubMed
  165. Weiss FD, et al. 2021. Nat Commun. 12:2919. PubMed
  166. Mallach A, et al. 2021. Cells. 10:. PubMed
  167. Hernandez-Clavijo A, et al. 2022. Cell Physiol Biochem. 56:254. PubMed
  168. Wang W, et al. 2021. EMBO J. 40:e106771. PubMed
  169. Lin YC, et al. 2021. Nat Neurosci. 24:1077. PubMed
  170. Lim JY, et al. 2021. Stem Cell Res Ther. 12:402. PubMed
  171. Mifsud KR, et al. 2021. Nat Commun. 12:4737. PubMed
  172. Li Y, et al. 2022. Front Neurosci. 16:945277. PubMed
  173. Kim K, et al. 2015. PLoS One. 10: 0142693. PubMed
  174. Mazzulli J, et al. 2016. Proc Natl Acad Sci U S A. 113: 1931 - 1936. PubMed
  175. Soares V, et al. 2016. Neuro Oncology. 10.1093/neuonc/now099. PubMed
  176. Mikami Y, et al. 2016. EBioMedicine. 11: 253-261. PubMed
  177. Pal-Ghosh S, et al. 2020. Invest Ophthalmol Vis Sci. 61:01:00. PubMed
  178. Janz A, et al. 2021. Stem Cell Research. 53:102256. PubMed
  179. Janssens S, et al. 2018. mSystems. 3. PubMed
  180. Thomas RA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  181. Tripathy R, et al. 2018. Neuron. 100:1354. PubMed
  182. Lenz KM, et al. 2018. J Neurosci. 38:8044. PubMed
  183. Nam H et al. 2019. Elife. 8 pii: e46683. PubMed
  184. Boucherie C, et al. 2018. Mol Psychiatry. 23:723. PubMed
  185. Leibinger M et al. 2019. Commun Biol. 0.304166667 . PubMed
  186. Mura M et al. 2019. Stem Cell Res. 1727:37:00 . PubMed
  187. Hansen M et al. 2017. Stem cell research. 25:34-37 . PubMed
  188. Yang SC, et al. 2019. FASEB J. 33:10577. PubMed
  189. Qiang L, et al. 2019. Hum Mol Genet. 28:1136. PubMed
  190. Iyer AA, et al. 2022. Elife. 11:. PubMed
  191. Cheng Y, et al. 2022. Nat Commun. 13:4418. PubMed
  192. Ramirez S, et al. 2021. Cells. 10:. PubMed
  193. Wareham LK, et al. 2021. iScience. 24:103141. PubMed
  194. Abe K, et al. 2021. Biophys J. 120:3566. PubMed
  195. Mura M, et al. 2019. Stem Cell Research. 42:101658. PubMed
  196. Alkobtawi M, et al. 2021. Cell Reports. 35(12):109289. PubMed
  197. Li W, et al. 2021. Stem Cell Research. 53:102259. PubMed
  198. Haas M, et al. 2016. Cell Rep. 15:2251-2265. PubMed
  199. Itoh Y, et al. 2016. Proc Natl Acad Sci U S A. 113: 2955 - 2964. PubMed
  200. Nagao M, et al. 2016. Nat Commun. 7:11102. PubMed
  201. Taverna E, et al. 2016. Sci Rep. 6:21206. PubMed
  202. Ulbrich L, et al. 2016. Biochem J. 473: 423 - 434. PubMed
  203. Barry D, et al. 2012. J Neurosci. 32:6209-6219. PubMed
  204. Catanese A, et al. 2019. Autophagy. 15:1719. PubMed
  205. Pettingill P, et al. 2019. Brain. 142:3852. PubMed
  206. Wang SE, et al. 2019. Exp Neurobiol. 28:537. PubMed
  207. Song Z, et al. 2019. Front Cell Dev Biol. 0.352083333. PubMed
  208. Wang L et al. 2016. The Journal of comparative neurology. 524(11):2322-34 . PubMed
  209. Hansen M et al. 2017. Stem cell research. 25:42-45 . PubMed
  210. Herdy J et al. 2019. Elife. 8 pii: e41356. PubMed
  211. Vicario N et al. 2019. Molecular neurobiology. 56(11):7338-7354 . PubMed
  212. Child KM et al. 2018. The Journal of Neuroscience. 38(31):6806-6824 . PubMed
  213. Fujitani M, et al. 2017. Mol Psychiatry. 22:364. PubMed
  214. Hockman D, et al. 2018. Dev Biol. 444:s308. PubMed
  215. Barbiero I, et al. 2017. Hum Mol Genet. 26:3520. PubMed
  216. Coleman JH, et al. 2019. J Neurosci. 39:814. PubMed
  217. Luo C et al. 2019. eLife. 8 pii: e40197. PubMed
  218. Liu L et al. 2017. Cell metabolism. 26(5):719-737 . PubMed
  219. Knudsen JG et al. 2018. Cell metabolism. 29(2):430-442 . PubMed
  220. Millan‐Zambrano G et al. 2018. Molecular cell. 72(4):625-635 . PubMed
  221. Sevilla A et al. 2018. Stem cell research. 29:99-102 . PubMed
  222. Muthusamy N, et al. 2018. Sci Rep. 8:1766. PubMed
  223. Guerriero I, et al. 2021. PLoS One. 16:e0253828. PubMed
  224. Diao X, et al. 2021. Cells. 10:. PubMed
  225. Lamotte JD, et al. 2021. Front Pharmacol. 11:617867. PubMed
  226. Paik S, et al. 2021. Biomedicines. 9:. PubMed
  227. Nehme R, et al. 2022. Nat Commun. 13:3690. PubMed
  228. Xia L, et al. 2022. Front Pharmacol. 13:881195. PubMed
  229. Zhang L, et al. 2022. Front Aging Neurosci. 14:926485. PubMed
  230. Lu P, et al. 2022. Invest Ophthalmol Vis Sci. 63:18. PubMed
  231. Heuermann ML, et al. 2022. Front Cell Neurosci. 16:841864. PubMed
  232. McSweeney D, et al. 2022. iScience. 25:105187. PubMed
  233. Caiazzo M, et al. 2016. Nat Mater. 0.1038/nmat4536. PubMed
  234. Fan C, et al. 2016. Sci Rep. 6:19579. PubMed
  235. Vanderperre B, et al. 2016. PLoS Genet. 12: 1006056. PubMed
  236. Wang T, et al. 2016. Nat Commun. 7: 12976. PubMed
  237. Pei S, et al. 2016. Sci Rep. 6:33822. PubMed
  238. M Rodriguez, S Noctor, E Muñoz 2016. PLoS One. 11:e0167063. PubMed
  239. Ahn LY, et al. 2021. J Neurosci Res. 99:110. PubMed
  240. Black JB, et al. 2020. Cell Rep. 33:108460. PubMed
  241. Birkhoff JC, et al. 2020. Hum Mol Genet. 29:2535. PubMed
  242. Pereiro X, et al. 2020. Cells. 9:00. PubMed
  243. Berenguer-Escuder C, et al. 2020. Human Molecular Genetics. 29(8):1353-1364. PubMed
  244. Tapias A, et al. 2021. eLife. 10:00. PubMed
  245. Dong L, et al. 2021. Stem Cell Research. 53:102260. PubMed
  246. Zhang T, et al. 2021. STAR Protocols. 2(1):100346. PubMed
  247. Arribas-Carreira L, et al. 2019. Stem Cell Research. 39:101503. PubMed
  248. Schoger E, et al. 2021. Stem Cell Research. 56:102518. PubMed
  249. Klima S, et al. 2020. ALTEX. . PubMed
  250. Kuwahara H, et al. 2018. Sci Rep. 8:4377. PubMed
  251. Anne Jacob et al. 2018. Journal of neurochemistry. 146(3):251-268 . PubMed
  252. Lehrman EK et al. 2018. Neuron. 100(1):120-134 . PubMed
  253. Valdez C, et al. 2017. Hum Mol Genet. 26:4861. PubMed
  254. Moakley D, et al. 2019. Sci Rep. 9:10835. PubMed
  255. Malkemper EP, et al. 2018. Biol Open. 7:bio034462. PubMed
  256. Stratton JA et al. 2018. Cell reports. 24(10):2561-2572 . PubMed
  257. Neurohr GE, et al. 2019. Cell. 176:1083. PubMed
  258. Hermanto Y et al. 2019. Journal of neuroscience research. 97(7):828-845 . PubMed
  259. An D, et al. 2019. Elife. 8:e44423. PubMed
  260. Voronova A et al. 2017. Neuron. 94(3):500-516 . PubMed
  261. Hilla AM et al. 2017. The Journal of Neuroscience. 37(25):6113-6124 . PubMed
  262. Bustos F, et al. 2018. Cell Rep. 2.06875. PubMed
  263. Mayanagi T, et al. 2020. Front Cell Neurosci. 0.933333333. PubMed
  264. Arsić A, et al. 2020. Sci Rep. 10:6441. PubMed
  265. Edwards G, et al. 2020. Cell Death Dis. 11:254. PubMed
  266. Nishimura K, et al. 2017. PLoS One. 12:e0170568. PubMed
  267. Roselló-Busquets C, et al. 2020. Front Mol Neurosci. 13:56. PubMed
  268. Wang X, et al. 2019. Front Neurosci. 1.324305556. PubMed
  269. Ha GH, et al. 2022. Aging (Albany NY). 14:. PubMed
  270. Meyer Zu Reckendorf S, et al. 2022. J Neurosci. 42:2474. PubMed
  271. van Niekerk EA, et al. 2022. Cell Rep Methods. 2:100255. PubMed
  272. Nouri P, et al. 2022. Cells. 11:. PubMed
  273. Amo-Aparicio J, et al. 2021. Theranostics. 11:9805. PubMed
  274. Fagerlund I, et al. 2021. Cells. 11:. PubMed
  275. Petrovic A, et al. 2022. Int J Mol Sci. 23:. PubMed
  276. Colombo S, et al. 2022. Development. 149:. PubMed
  277. Sidoli M, et al. 2021. J Neurosci. 41:4536. PubMed
  278. Simone R, et al. 2021. Nature. 594:117. PubMed
  279. Li A, et al. 2021. STAR Protoc. 2:100580. PubMed
  280. Osuka S, et al. 2021. J Clin Invest. 131: . PubMed
  281. Lasman L, et al. 2020. Genes Dev. 34:1373. PubMed
  282. Wong HS, et al. 2021. Cell. . PubMed
  283. Kim JW, et al. 2020. Cell Stem Cell. 27(4):633-645.e7. PubMed
  284. Evsen L, et al. 2020. Development. 147:00:00. PubMed
  285. Huang YA, et al. 2020. J Cell Sci. 133:00:00. PubMed
  286. Levin G, et al. 2020. Front Bioeng Biotechnol. 0.663888889. PubMed
  287. Seo HH, et al. 2020. Emerg Microbes Infect. 1.724305556. PubMed
  288. Laura Kerosuo, Marianne E. Bronner 2016. Cell Rep. 17:2648-2659. PubMed
  289. George L, et al. 2016. Dev Biol. 413:70-85. PubMed
  290. Ferletta M, et al. 2011. Int J Cancer. 129:45-60. PubMed
  291. Banal C, et al. 2020. Stem Cell Research. 72.78888889. PubMed
  292. Zhao J, et al. 2020. Aging (Albany NY). 12:5590. PubMed
  293. Themeli M, et al. 2020. Stem Cell Reports. 14:300. PubMed
  294. Ding D, et al. 2020. J Otol. 15:36. PubMed
  295. Ilouz R et al. 2017. eLife. 6 pii: e17681. PubMed
  296. Kwart D et al. 2019. Neuron. 104(2):256-270 . PubMed
  297. Di Bella DJ, et al. 2019. Cell Rep. 28:2264. PubMed
  298. Velychko S et al. 2019. Cell reports. 27(1):30-39 . PubMed
  299. Kim J, et al. 2018. Development. 145. PubMed
  300. Yang T et al. 2018. Cell reports. 24(10):2694-2708 . PubMed
  301. Cheng LS, et al. 2017. Pediatr Res. 81:838. PubMed
  302. Augé E, et al. 2018. Sci Rep. 8:13525. PubMed
  303. Shin BC et al. 2018. The Journal of Neuroscience. 38(44):9579-9599 . PubMed
  304. Cárdenas A et al. 2018. Cell. 174(3):590-606 . PubMed
  305. Goffena J, et al. 2018. Nat Commun. 9:889. PubMed
  306. Ogawa Y, et al. 2017. PLoS One. 12(6):e0178978. PubMed
  307. Zheng Z, et al. 2021. Cell Biol Toxicol. Online ahead of prin. PubMed
  308. Lim SH, et al. 2020. J Cell Sci. . PubMed
  309. Salti A, et al. 2021. Cells. 10:. PubMed
  310. Araki R, et al. 2021. Heliyon. 7:e08071. PubMed
  311. Ye E, et al. 2022. Int J Oncol. 60:. PubMed
  312. Taïb S, et al. 2022. Elife. 11:. PubMed
  313. Bérenger-Currias NM, et al. 2022. J Tissue Eng. 13:20417314221103042. PubMed
  314. Wirt S, et al. 2010. J Cell Biol. 191:809-825. PubMed
  315. Wang Q, et al. 2016. Sci Rep. 6:19003. PubMed
  316. Petracca Y, et al. 2016. Development. 143: 880 - 891. PubMed
  317. Lalli M, et al. 2016. Hum Mol Genet. 25: 1294-1306. PubMed
  318. Thakurela S, et al. 2016. Sci Rep. 6: 25828. PubMed
  319. Bedogni F, et al. 2016. Cereb Cortex. 26: 2517 - 2529. PubMed
  320. Landegger L, et al. 2017. Nat Biotechnol. 35:280-284. PubMed
  321. Pournasr B, et al. 2020. Stem Cell Res. 48:101953. PubMed
  322. Trapecar M, et al. 2021. Sci Adv. 7:00. PubMed
  323. Smith KE, et al. 2020. Journal of Neuroscience Research. 99(2):679-698. PubMed
  324. Isaja L, et al. 2021. Stem Cell Research. 53:102325. PubMed
  325. Elsayed AK, et al. 2021. Stem Cell Research. 56:102500. PubMed
  326. Bargagna-Mohan P, et al. 2020. J Neurosci Res. . PubMed
  327. Lee N, et al. 2021. Biochem Biophys Rep. 100973:26. PubMed
  328. Chau KF, et al. 2018. Elife. 19:E663. PubMed
  329. Sun S et al. 2018. Cell. 174(5):1247-1263 . PubMed
  330. Yi‐Lan Weng et al. 2018. Neuron. 97(2):313-325 . PubMed
  331. Bachmann SO, et al. 2019. Transl Psychiatry. 9:29. PubMed
  332. Sabo JK, et al. 2017. Ann Neurol. 81:560. PubMed
  333. Gao L, et al. 2019. Front Cell Neurosci. 13:316. PubMed
  334. Shao Q et al. 2019. PLoS One. 14(6):e0218811 . PubMed
  335. Mohlin S, et al. 2019. EMBO Mol Med. 11:e10058. PubMed
  336. Ibañez Rodriguez MP et al. 2018. The Journal of comparative neurology. 526(15):2462-2481 . PubMed
  337. Duan RS, et al. 2018. Cell Death Differ. 25:1598. PubMed
  338. Pollen AA, et al. 2019. Cell. 176:743. PubMed
  339. Corman A, et al. 2019. Cell Chem Biol. 26:235. PubMed
  340. Molotkov A et al. 2017. Developmental cell. 41(5):511-526 . PubMed
  341. Yang C, et al. 2020. Neuron. 105:276. PubMed
  342. Marchetta P, et al. 2020. Front Aging Neurosci. 12:83. PubMed
  343. Fujiwara N, et al. 2022. Pediatr Surg Int. 39:18. PubMed
  344. Zhu Z, et al. 2022. Aging Cell. 21:e13587. PubMed
  345. Schaeffer J, et al. 2022. Front Cell Dev Biol. 10:917589. PubMed
  346. Li J, et al. 2021. Neural Plast. 2021:4894881. PubMed
  347. Wilmerding A, et al. 2021. Int J Mol Sci. 22:. PubMed
  348. Hu D, et al. 2021. Nat Commun. 12:5305. PubMed
  349. Russo-Savage L, et al. 2020. Neurobiol Aging. 95:69. PubMed
  350. Urciuolo A, et al. 2020. Nat Biomed Eng. 4:901. PubMed
  351. Sadick JS, et al. 2020. Ann Biomed Eng. 48:2218. PubMed
  352. Lecomte A, et al. 2020. Adv Biosyst. e2000114:4. PubMed
  353. Wang L, et al. 2020. Nat Commun. 3.2625. PubMed
  354. Sheehan CJ, et al. 2020. Development. 147:00:00. PubMed
  355. Zabolocki M, et al. 2020. Nat Commun. 4.3125. PubMed
  356. Liu R, et al. 2021. Oncol Lett. 21:06. PubMed
  357. Zhang X, et al. 2020. Sci Adv. 6:00. PubMed
  358. Sadick J, et al. 2016. Sci Rep. 6: 33999. PubMed
  359. Guo S, Du Y, Liu X 2016. Nat Commun. 7:12230. PubMed
  360. Kushwaha R, et al. 2016. Stem Cell Reports. 6:772-783. PubMed
  361. Paquet D, et al. 2016. Nature. 533: 125-129. PubMed
  362. Binder Z, et al. 2016. PLoS One. 11: 0150271. PubMed
  363. He H, et al. 2016. J Neurosci. 36: 3079 - 3091. PubMed
  364. Khong ZJ, et al. 2020. Cell Death Dis. 11:182. PubMed
  365. Pinheiro H, et al. 2018. Front Pharmacol. 0.527083333. PubMed
  366. Ichihara–Tanaka K, et al. 2017. J Histochem Cytochem. 65:513. PubMed
  367. Harrington AJ et al. 2016. eLife. 5 pii: e20059. PubMed
  368. Michael Lerche et al. 2017. Structure (London, England : 1993). 25(8):1175-1186 . PubMed
  369. Larhammar M et al. 2017. eLife. 6 pii: e20725. PubMed
  370. Lavado A et al. 2018. Dev Cell. 47(5):576-591 . PubMed
  371. Freeman S et al. 2019. EMBO Rep. 20(9):e47097 . PubMed
  372. Kaur T, et al. 2019. Front Neurosci. 13:620. PubMed
  373. Nash B et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed
  374. Sarkar C, et al. 2019. Autophagy. N/A. PubMed
  375. Tramarin M, et al. 2018. Hum Mol Genet. 27:2052. PubMed
  376. Xue J, et al. 2017. ACS Appl Mater Interfaces. 9:12299. PubMed
  377. Toda T, et al. 2017. Cell Stem Cell. 21:618. PubMed
  378. Amaral JD, et al. 2019. Front Chem. 7:15. PubMed
  379. Wang XW, et al. 2018. Cell Rep. 24:2540. PubMed
  380. Tavano S et al. 2018. Neuron. 97(6):1299-1314 . PubMed
  381. Luisier R, et al. 2018. Nat Commun. 8:6458. PubMed
  382. de Matos AM, et al. 2020. J Med Chem. 63:11663. PubMed
  383. Calamini B, et al. 2021. Dis Model Mech. 14:. PubMed
  384. Gandhi S, et al. 2021. Development. 148:. PubMed
  385. Stern S, et al. 2021. Neuron. 109:3436. PubMed
  386. Nath M, et al. 2022. Eneuro. 9:. PubMed
  387. Pinto M, et al. 2016. J Cell Biol. 212: 789 - 801. PubMed
  388. Okamoto M, et al. 2016. Nat Commun. 7: 11349. PubMed
  389. Liu X, et al. 2016. Nat Commun. 7:11508. PubMed
  390. Grandi FC, et al. 2020. Front Mol Neurosci. 0.599305556. PubMed
  391. Ewan EE, et al. 2021. Sci Rep. 0.718055556. PubMed
  392. Brievac D, et al. 2020. Journal of Neurochemistry. 157(3):666-683. PubMed
  393. Hu Z, et al. 2020. Cell Rep. 107657:31. PubMed
  394. Lehtonen Ŝ et al. 2018. Stem cell research. 30:96-99 . PubMed
  395. Qiang L et al. 2018. Current biology : CB. 28(13):2181-2189 . PubMed
  396. Hor JH, et al. 2018. Cell Death Dis. 9:1100. PubMed
  397. Gupta S et al. 2017. Journal of neurochemistry. 145(3):188-203 . PubMed
  398. Howlett EH, et al. 2017. Hum Mol Genet. 26:4340. PubMed
  399. Zunke F et al. 2017. Neuron. 97(1):92-107 . PubMed
  400. Fernandes KA, et al. 2018. Exp Eye Res. 171:54. PubMed
  401. Linkous A et al. 2019. Cell reports. 26(12):3203-3211 . PubMed
  402. Pronin A, et al. 2019. Front Mol Neurosci. 12:36. PubMed
  403. Meijer M et al. 2019. Cell Rep. 27(7):2199-2211 . PubMed
  404. Lin CI et al. 2019. eNeuro. 6(4) pii: ENEURO. PubMed
  405. Auboyer L et al. 2019. Stem Cell Res. 1723:41:00 . PubMed
  406. Kurtenbach S et al. 2017. PloS one. 12(11):e0187576 . PubMed
  407. Yu M et al. 2017. Cell research. 27(12):1441-1465 . PubMed
  408. Huh CJ et al. 2016. eLife. 5 pii: e18648. PubMed
  409. Li J, et al. 2018. Neural Plast. 2018:6890613. PubMed
  410. Chen YT, et al. 2019. Stem Cell Res Ther. 0.6875. PubMed
  411. Syal C, et al. 2020. Theranostics. 10:6337. PubMed
  412. Contreras E, et al. 2022. Cell Tissue Res. :. PubMed
  413. Sluysmans S, et al. 2021. Mol Biol Cell. 32:ar34. PubMed
  414. Ma C, et al. 2022. Int J Mol Med. 50:. PubMed
  415. Khan M, et al. 2021. Cell. 184:5932. PubMed
  416. Xu PF, et al. 2021. Nature Communications. 12(1):3277. PubMed
  417. Anderson EM, et al. 2021. Addiction Biology. :e13060. PubMed
  418. Lin NH, et al. 2021. The FASEB Journal. 35(5):e21614. PubMed
  419. Leibinger M, et al. 2021. Nature Communications. 12(1):391. PubMed
  420. Huang S, et al. 2020. Cell Rep. 33:108394. PubMed
  421. Rubio A, et al. 2016. Sci Rep. 6:37540. PubMed
  422. Intoh A, et al. 2016. Hum Mol Genet. 10.1093/hmg/ddw053. PubMed
  423. Sancho-Martinez I, et al. 2016. Nat Commun. 7:10743. PubMed
  424. Jouhilahti E, et al. 2008. J Histochem Cytochem. 56:1113-1119. PubMed
  425. Gilliam EA, et al. 2020. American Journal of Physiology-Gastrointestinal and Liver Physiology. 319(2):G261-G279.. PubMed
  426. Dionisi C, et al. 2020. Sci Rep. 10:7752. PubMed
  427. Lindsay CD, et al. 2019. Acta Biomater. 95:225. PubMed
  428. Makdissy N, et al. 2018. Stem Cell Res Ther. 0.466666667. PubMed
  429. Mettang M, et al. 2018. FASEB J. 32:1916. PubMed
  430. Chen X et al. 2017. Developmental cell. 43(5):563-576 . PubMed
  431. Hegarty DM, et al. 2017. J Comp Neurol. 525:2019. PubMed
  432. Tsuboi M, et al. 2018. Dev Cell. 47:758. PubMed
  433. Sharma N et al. 2019. Neuron. 102(2):390-406 . PubMed
  434. Mo J, et al. 2017. Invest Ophthalmol Vis Sci. 58:137. PubMed
  435. Rhee HJ et al. 2019. Cell Rep. 27(7):2212-2228 . PubMed
  436. Makar T, et al. 2018. Stem Cell Res Ther. 9:127. PubMed
  437. Debadrita Bhattacharya et al. 2018. eLife. 7 pii: e40556. PubMed
  438. Zahr SK et al. 2018. Neuron. 97(3):520-537 . PubMed
  439. Kim YJ, et al. 2018. Neuron. 100:1180. PubMed
  440. Borys BS, et al. 2021. Stem Cell Res Ther. 12:55. PubMed
  441. Little JN, et al. 2021. J Neurosci. 41:3344. PubMed
  442. Sanchez CG, et al. 2021. Commun Biol. 4:736. PubMed
  443. Wang L, et al. 2021. Nat Med. 27:1600. PubMed
  444. Sepehrimanesh M, et al. 2021. STAR Protoc. 2:100917. PubMed
  445. Barbuti PA, et al. 2021. Sci Rep. 11:21946. PubMed
  446. Meng X, et al. 2022. Proc Natl Acad Sci U S A. 119:. PubMed
  447. Argolo DS, et al. 2022. Int J Tryptophan Res. 15:11786469211069946. PubMed
  448. Li Y, et al. 2022. J Cell Biol. 221:. PubMed
  449. Yamamoto Y, et al. 2022. Life Sci Alliance. 5:. PubMed
  450. Chen J, et al. 2021. Int J Mol Sci. 23:. PubMed
  451. Zhang H, et al. 2022. Elife. 11:. PubMed
  452. Tang J, et al. 2022. Antioxidants (Basel). 11:. PubMed
  453. Xue Y, et al. 2016. Nat Neurosci. 19: 807-15. PubMed
  454. Muscat A, et al. 2016. Clin Cancer Res. 22: 3560 - 3570. PubMed
  455. Sandor C, et al. 2017. Hum Mol Genet. 10.1093/hmg/ddw412. PubMed
  456. Ingersoll MA, et al. 2020. Sci Adv. 6:00. PubMed
  457. Jiang B, et al. 2020. Sci Adv. 6:00. PubMed
  458. Barbuti PA, et al. 2020. Cells. 9:00. PubMed
  459. Vila-Cejudo M, et al. 2018. Journal of Assisted Reproduction and Genetics. 36(1):99-111. PubMed
  460. Koinuma S, et al. 2020. Journal of Neurochemistry. 157(4):1196-1206. PubMed
  461. Dementyeva EV, et al. 2021. Stem Cell Research. 53:102344. PubMed
  462. Han JS, et al. 2020. Proc Natl Acad Sci U S A. 23073:117. PubMed
  463. Gupta S, et al. 2021. STAR Protoc. 100319:2. PubMed
  464. Hertzano R, et al. 2020. Laryngoscope. . PubMed
  465. Flaherty E,et al. 2017. NPJ Schizophr.. 10.1038/s41537-017-0033-5. PubMed
  466. Ryan T, et al. 2018. Nat Commun. 9:817. PubMed
  467. Moon KH et al. 2018. Developmental cell. 44(1):13-28 . PubMed
  468. Xu Z, et al. 2019. Front Neurosci. 12:970. PubMed
  469. Joanna Ruth Appel et al. 2018. The Journal of Neuroscience. 38(26):5949-5968 . PubMed
  470. Vyas P, et al. 2019. Sci Rep. 9:5549. PubMed
  471. Zhang N, et al. 2019. Adv Sci (Weinh). 6:1800808. PubMed
  472. Singh K, et al. 2018. Front Mol Neurosci. 11:30. PubMed
  473. Friocourt F et al. 2019. The Journal of comparative neurology. 527(12):2009-2029 . PubMed
  474. Weng YL, et al. 2017. Neuron. 94:337. PubMed
  475. Espuny‐Camacho I et al. 2017. Neuron. 93(5):1066-1081 . PubMed
  476. Park JH, et al. 2018. Mol Cell Biol. 38:e00217. PubMed
  477. Ozaki K, et al. 2019. Invest Ophthalmol Vis Sci. 60:4151. PubMed
  478. Llères D, et al. 2019. Genome Biol. 1.022222222. PubMed
  479. Dourado NS, et al. 2020. Front Aging Neurosci. 12:119. PubMed
  480. Götzl JK, et al. 2018. Mol Neurodegener. 13:48. PubMed
  481. Reyes RV, et al. 2022. Front Neurosci. 16:908719. PubMed
  482. He B, et al. 2021. J Anat. 239:913. PubMed
  483. Arsic A, et al. 2022. Nat Commun. 13:314. PubMed
  484. Calamini B, et al. 2021. Dis Model Mech. . PubMed
  485. Brown D, et al. 2021. Neurotherapeutics. 18:387. PubMed
  486. Wang M, et al. 2021. Neuron. 109:257. PubMed
  487. Ren J, et al. 2021. Cells. 10:. PubMed
  488. Cui K, et al. 2020. Microsyst Nanoeng. 6:49. PubMed
  489. Cuddy LK, et al. 2021. STAR Protoc. 100340:2. PubMed
  490. Matern MS, et al. 2020. Development. :147. PubMed
  491. Nikulina E, et al. 2020. FEBS Lett. 1389:594. PubMed
  492. Ghita L, et al. 2021. Journal of Neuroscience Research. :. PubMed
  493. Simon DJ, et al. 2021. Developmental Cell. 56(7):976-984.e3. PubMed
  494. Maor-Nof M, et al. 2021. Cell. 184(3):689-708.e20. PubMed
  495. Kraemer BR, et al. 2020. Neuroscience. 453:222-236. PubMed
  496. Schörnig M, et al. 2021. Elife. 10:00. PubMed
  497. Camilieri-Asch V, et al. 2020. Front Neuroanat. 14:560534. PubMed
  498. Durak O, et al. 2016. Nat Neurosci. 19:1477-1488. PubMed
  499. Drobish J, et al. 2016. Toxicol Sci. 154(2):309-319. PubMed
  500. Marchetto M, et al. 2016. Mol Psychiatry. 10.1038/mp.2016.95. PubMed
  501. Wang W, et al. 2016. Nat Commun. 7:10936. PubMed
  502. Tanimoto R, et al. 2016. Sci Rep. 6:22071. PubMed
  503. Stathakos P, et al. 2020. Autophagy. :1. PubMed
  504. Huang YA, et al. 2019. J Neurosci. 39:7408. PubMed
  505. Dang LT, et al. 2020. Front Cell Neurosci. 14:122. PubMed
  506. Sloan SA et al. 2017. Neuron. 95(4):779-790 . PubMed
  507. Shao Q et al. 2017. The Journal of Neuroscience. 37(23):5620-5633 . PubMed
  508. Wu JS et al. 2017. The Journal of comparative neurology. 526(3):425-438 . PubMed
  509. Wu C, et al. 2019. Cell Rep. 26:1143. PubMed
  510. Vassilev V, et al. 2017. Dev Cell. 43:463. PubMed
  511. Kim J, et al. 2017. Histochem Cell Biol. 148:489. PubMed
  512. Thayer JA, et al. 2019. Autophagy. 7:1-14. PubMed
  513. Liu WA, et al. 2018. Genes Dev. 32:763. PubMed
  514. Trajkovic K, et al. 2019. PLoS One. 14:e0211727. PubMed
  515. Oksanen M et al. 2018. Stem cell research. 31:181-185 . PubMed
  516. Johansson E, et al. 2017. Cell Rep. 10.1016/j.celrep.2017.07.049. PubMed
  517. Petrovic A, et al. 2021. Front Cell Neurosci. 15:661492. PubMed
  518. Liang D, et al. 2021. Nat Neurosci. 24:941. PubMed
  519. Lautz JD, et al. 2021. Cell Rep. 37:110076. PubMed
  520. De La Rossa A, et al. 2022. Elife. 11:. PubMed
  521. Rabadán MA, et al. 2022. Nat Commun. 13:3340. PubMed
  522. Williams LA, et al. 2022. Mol Ther Nucleic Acids. 29:189. PubMed
  523. Vahsen BF, et al. 2022. Sci Rep. 12:12606. PubMed
  524. Sefiani A, et al. 2022. Sci Rep. 12:13125. PubMed
  525. Tay SH, et al. 2021. Methods Mol Biol. 2549:359. PubMed
  526. Fisher ES, et al. 2022. J Neuroinflammation. 19:266. PubMed
  527. Quintes S, et al. 2016. Nat Neurosci. 10.1038/nn.4321. PubMed
  528. Demais V, et al. 2016. J Neurosci. 36: 8012 - 8025. PubMed
  529. Borromeo M, et al. 2016. Cell Rep. 16:1259-1272. PubMed
  530. Borgs L, et al. 2016. Sci Rep. 6: 33377. PubMed
  531. Enriquez‐Rios V et al. 2017. The Journal of Neuroscience. 37(4):893-905 . PubMed
  532. Shi W, et al. 2017. Nat Neurosci. 10.1038/nn.4519. PubMed
  533. Brann DH, et al. 2020. Sci Adv. 6:00. PubMed
  534. McNeely KC, et al. 2020. Proc Natl Acad Sci U S A. 117:9584. PubMed
  535. Li Y, et al. 2021. Stem Cell Research. 55:102460. PubMed
  536. Hilla AM, et al. 2018. BIO-PROTOCOL. 8(16):e2979. PubMed
  537. Kitajima R, et al. 2020. Stem Cell Res. 101749:44. PubMed
  538. Fouda AY, et al. 2020. Invest Ophthalmol Vis Sci. 51:61. PubMed
  539. Wu X, et al. 2018. Cell. 172:423. PubMed
  540. Buijsen RAM et al. 2018. Stem cell research. 29:125-128 . PubMed
  541. Miquel‐Serra L et al. 2018. Stem cell research. 24:155-159 . PubMed
  542. Senft AD, et al. 2018. Cell Rep. 24:1977. PubMed
  543. Gao L, et al. 2019. Sci Rep. 9:3462. PubMed
  544. Xu Z, et al. 2018. Development. 145:. PubMed
  545. Christiansen EM, et al. 2018. Cell. 173:792. PubMed
  546. Rich CA, et al. 2018. Glia. 66:2617. PubMed
  547. Heil C, et al. 2019. Open Biol. 9:180145. PubMed
  548. Wanner R, et al. 2019. Front Neurol. 10:310. PubMed
  549. Hickey SL et al. 2019. Cell reports. 27(6):1699-1711 . PubMed
  550. Suarato G, et al. 2017. Biomaterials. 112:176. PubMed
  551. Watanabe Y, et al. 2018. Development. 145. PubMed
  552. Chanda S et al. 2019. Cell Stem Cell. 25(1):103-119 . PubMed
  553. Wu Z, et al. 2019. Neuron. 101:635. PubMed
  554. Bachmann SB, et al. 2019. Cell Rep. 27:3305. PubMed
  555. Kaplan A, et al. 2017. Neuron. 93:1082. PubMed
  556. Tozer S, et al. 2017. Neuron. 93:542. PubMed
  557. Leibinger M et al. 2017. Proceedings of the National Academy of Sciences of the United States of America. 114(27):E5454-E5463 . PubMed
  558. Syc–Mazurek SB, et al. 2018. Cell Death Dis. 1.135416667. PubMed
  559. Kang PH, et al. 2020. Mol Biol Cell. 31:386. PubMed
  560. Tehrani S, et al. 2018. Sci Rep. 8:4453. PubMed
  561. Russo R, et al. 2018. Cell Death Dis. 1.05625. PubMed
  562. Suenkel C, et al. 2020. Cell Reports. 30(7):2170-2179. PubMed
  563. Peitz M, et al. 2020. STAR Protoc. 1:100038. PubMed
  564. Rantanen LM, et al. 2022. Cells. 11:. PubMed
  565. Hamity MV, et al. 2022. Invest Ophthalmol Vis Sci. 63:38. PubMed
  566. Lam AN, et al. 2021. Data Brief. 35:106897. PubMed
  567. Cui K, et al. 2022. Cell Regen. 11:7. PubMed
  568. Zhao D, et al. 2021. Cell Death Differ. 28:337. PubMed
  569. Schenk MS, et al. 2021. Transl Vis Sci Technol. 10:22. PubMed
  570. Dong Y, et al. 2021. STAR Protoc. 2:100853. PubMed
  571. Calado SM, et al. 2021. Stem Cell Research. 55:102462. PubMed
  572. Bieler M, et al. 2021. Journal of Comparative Neurology. 529(12):3194-3205. PubMed
  573. Kondo N, et al. 2020. Cancers (Basel). 12:00. PubMed
  574. Friocourt F, et al. 2017. Sci Rep. 7:37569. PubMed
  575. Fimiani C, et al. 2016. Sci Rep. 6:39311. PubMed
  576. Damiani D, et al. 2016. Nat Commun. 7:13509. PubMed
  577. Hegazy A, et al. 2016. J Biol Chem. 291: 21496 - 21509. PubMed
  578. Maison S, Liberman L, Liverman M 2016. eNeuro. 3: ENEURO.0207-16.2016. PubMed
  579. Edmondson R, Adock A, Yang L 2016. PLoS One. 11: 0158116. PubMed
  580. Jablonski K, et al. 2016. Stem Cell Reports. 8: 1119-1127. PubMed
  581. Rraklli V, et al. 2016. Stem Cell Res. 16:1-9. PubMed
  582. Kizuka Y, et al. 2016. Biochem J. 473: 21 - 30. PubMed
  583. Kim K, et al. 2013. J Cell Biol. 200:443-458. PubMed
  584. Cesca F, et al. 2012. Cell Death Differ. 19:194-208. PubMed
  585. Yao H, et al. 2020. Sci Rep. 10:17445. PubMed
  586. Matthies D, et al. 2020. Sci Rep. 10:11953. PubMed
  587. Hattori Y, et al. 2020. Nat Commun. 11:1631. PubMed
  588. Duncan DS, et al. 2018. Front Neurosci. 0.9875. PubMed
  589. Welsbie DS et al. 2017. Neuron. 94(6):1142-1154 . PubMed
  590. Belle M et al. 2017. Cell. 169(1):161-173 . PubMed
  591. Walker LJ et al. 2017. eLife. 6 pii: e22540. PubMed
  592. Mura M et al. 2019. Stem Cell Res. 1727:31:00 . PubMed
  593. Gao F et al. 2019. Mol Cell. 75(5):891-904 . PubMed
  594. Kurabayashi N, et al. 2018. Development. 145. PubMed
  595. Miesfeld JB et al. 2017. Gene expression patterns : GEP. 27:114-121 . PubMed
  596. Calatayud C, et al. 2019. Sci Rep. 9:6811. PubMed
  597. Pai EL et al. 2019. Cell reports. 26(5):1157-1173 . PubMed
  598. Teng X, et al. 2018. Thyroid. 28:667. PubMed
  599. Sun L, et al. 2017. Oncotarget. 8:40065. PubMed
  600. Spitalieri P, et al. 2018. Front Physiol. 9:967. PubMed
  601. Erin Frey et al. 2018. eNeuro. 5(3) pii: ENEURO. PubMed
  602. Mura M et al. 2018. Stem cell research. 29:157-161 . PubMed
  603. Doucet-O'Hare TT, et al. 2021. Sci Rep. 11:12893. PubMed
  604. Gandhi S, et al. 2021. Development. 148:dev193565. PubMed
  605. Ketschek A, et al. 2021. J Neurosci. 41:6637. PubMed
  606. Park SH, et al. 2021. Biochem Pharmacol. 188:114520. PubMed
  607. Oksdath Mansilla M, et al. 2021. BMC Biomed Eng. 3:6. PubMed
  608. Flores-Otero J, et al. 2007. J Neurosci. 27:14023-14034. PubMed
  609. Wang L, Hou S, Han Y 2016. Nat Neurosci. 19: 888-896. PubMed
  610. Roese-Koerner B, et al. 2016. Stem Cell Reports. 7:207-219. PubMed
  611. Choi R, et al. 2020. Laryngoscope Investig Otolaryngol. 0.885416667. PubMed
  612. Ng AQE, et al. 2020. Cell Reports. 30(5):1434-1446.e7. PubMed
  613. Hawkins FJ, et al. 2020. Cell Stem Cell. 28(1):79-95.e8. PubMed
  614. Arber C, et al. 2021. Cell Reports. 34(2):108615. PubMed
  615. Zhang X, et al. 2021. Cell Reports. 34(11):108830. PubMed
  616. Czeisler C, et al. 2016. Journal of Comparative Neurology. 524(17):3485-3502. PubMed
  617. Abreu CA, et al. 2021. Journal of Neurochemistry. 158(3):694-709. PubMed
  618. Liu P, et al. 2017. Stem Cell Rep. 10.1016/j.stemcr.2017.05.007. PubMed
  619. Sommer A et al. 2018. Cell stem cell. 23(1):123-131 . PubMed
  620. Mains RE et al. 2018. Endocrinology. 159(7):2621-2639 . PubMed
  621. Kelly SM et al. 2018. Neuron. 99(2):345-361 . PubMed
  622. Han S, et al. 2018. Development. 145:. PubMed
  623. Friedl RM, et al. 2019. Dis Model Mech. 0.5. PubMed
  624. Khayati K, et al. 2017. FASEB J. 31:598. PubMed
  625. Comai G et al. 2019. Elife. 8 pii: e47460. PubMed
  626. Lee SG et al. 2018. Stem Cell Res. 31:197-200 . PubMed
  627. Zhu J et al. 2017. Cell stem cell. 20(3):374-384 . PubMed
  628. Gouti M, et al. 2017. Dev Cell. 41:243. PubMed
  629. Levin E et al. 2017. Scientific reports. 7(1):643 . PubMed
  630. Tokuyama MA, et al. 2018. Dev Biol. 433:287. PubMed
  631. Xie Y, et al. 2019. RNA Biol. 0.723611111. PubMed
  632. Yang D, et al. 2019. Elife. 8:e49249. PubMed
  633. Heinrich A, et al. 2020. Cell Rep. 31:107513. PubMed
  634. Park S, et al. 2020. PLoS Biol. 18:e3000296. PubMed
  635. Pappa S, et al. 2019. Proc Natl Acad Sci U S A. 116:19464. PubMed
  636. Marquardt LM, et al. 2020. Sci Adv. 6:eaaz1039. PubMed
  637. Xu X, et al. 2022. Biology (Basel). 11:. PubMed
  638. Namchaiw P, et al. 2022. PLoS One. 17:e0273458. PubMed
  639. Wu C, et al. 2022. J Hum Genet. :. PubMed
  640. Wilmerding A, et al. 2022. Neoplasia. 24:120. PubMed
  641. Yang Y, et al. 2022. Nucleic Acids Res. 50:191. PubMed
  642. Hilton BJ, et al. 2021. Neuron. S0896-6273:00775-3. PubMed
  643. Bassil R, et al. 2021. Nat Commun. 12:5220. PubMed
  644. Vaes N, et al. 2021. EMBO Rep. 22:e51913. PubMed
  645. Bouma MJ, et al. 2019. Stem Cell Research. 41:101654. PubMed
  646. Rebs S, et al. 2021. Stem Cell Research. 53:102263. PubMed
  647. Gao T, et al. 2021. JCI Insight. 6(10):. PubMed
  648. Liu W, et al. 2020. J Exp Med. 217:00:00. PubMed
  649. Franco A, et al. 2020. Elife. 9:00. PubMed
  650. Chen W, et al. 2017. eNeuro. 3(6). PubMed
  651. Teresa Rivera, Candy Haggblom, Sandro Cosconati 2016. Nat Struct Mol Biol. 24:30-39. PubMed
  652. Jager P, et al. 2016. Nat Commun. 7:13579. PubMed
  653. Zeltner N, et al. 2016. Nat Med. 22:1421-1427. PubMed
  654. Gaitán-Peñas H, et al. 2016. Biophys J. 111:1429-1443. PubMed
  655. Zalfa C, et al. 2016. Cell Death Dis. 7:e2331. PubMed
  656. Li S, et al. 2016. Sci Rep. 6:29514. PubMed
  657. Mita T, et al. 2016. J Biol Chem. 291: 4955 - 4965. PubMed
  658. Jia L, et al. 2018. Mol Neurobiol. 55:9089. PubMed
  659. Sun W, et al. 2020. J Clin Invest. 130:345. PubMed
  660. Baek C, et al. 2018. PLoS Biol. 16:e2004162. PubMed
  661. Miyake S et al. 2015. Cell death & disease. 6:e1638 . PubMed
  662. Wang L et al. 2017. The Journal of comparative neurology. 525(13):2915-2928 . PubMed
  663. Stratton JA et al. 2017. eNeuro. 4(3) pii: ENEURO. PubMed
  664. Norsworthy MW et al. 2017. Neuron. 94(6):1112-1120 . PubMed
  665. Brekk OR et al. 2018. Molecular and cellular neurosciences. 95:1-12 . PubMed
  666. Mura M et al. 2019. Stem cell research. 1726:16:00 . PubMed
  667. Jung JS, et al. 2019. J Neurosci. 39:6425. PubMed
  668. Fan D et al. 2019. Elife. 8 pii: e49226. PubMed
  669. Sarah E Pease‐Raissi et al. 2017. Neuron. 96(2):373-386 . PubMed
  670. Sorrells SF, et al. 2019. Nat Commun. 10:2748. PubMed
  671. Lee J, et al. 2018. Invest Ophthalmol Vis Sci. 59:3531. PubMed
  672. Alexander JM et al. 2019. Elife. 8 pii: e41769. PubMed
  673. Hu D, et al. 2019. Acta Neuropathol. 137:939. PubMed
  674. Acosta S, et al. 2018. Genesis. 56:e23212. PubMed
  675. Stallings NR, et al. 2018. Sci Signal. 11:522. PubMed
  676. Diacou R et al. 2018. Cell reports. 25(9):2510-2523 . PubMed
  677. Liu Y et al. 2018. Cell stem cell. 23(5):758-771 . PubMed
  678. Umegaki Y et al. 2018. The Journal of Neuroscience. 38(21):4985-4995 . PubMed
  679. Urrea L, et al. 2018. Mol Neurobiol. 15:1630. PubMed
  680. Gangoso E, et al. 2021. Cell. 184:2454. PubMed
  681. Sun Z, et al. 2021. Aging (Albany NY). 13:12587. PubMed
  682. Chen Y, et al. 2021. Nat Methods. 18:528. PubMed
  683. Cast TP, et al. 2021. J Neurosci. 41:392. PubMed
  684. Satoh M, et al. 2021. Int J Mol Sci. 22:. PubMed
  685. Eriksen AZ, et al. 2022. STAR Protoc. 3:101383. PubMed
  686. Kempfle JS, et al. 2021. Front Cell Neurosci. 15:666706. PubMed
  687. Guan Y, et al. 2021. Nat Commun. 12:5078. PubMed
  688. Yao X, et al. 2022. Nat Commun. 13:3883. PubMed
  689. Tasdemir-Yilmaz OE, et al. 2021. Dev Cell. 56:2516. PubMed
  690. Dudok J, et al. 2016. Neurosci Res. S0168-0102(16)00002-X. PubMed
  691. Rooney G, et al. 2016. J Neurosci. 36: 142 - 152.. PubMed
  692. Takeo Y, et al. 2016. Sci Rep. 6: 25180. PubMed
  693. Okamoto-Uchida Y, et al. 2016. Sci Rep. 6:37697. PubMed
  694. Wang H, et al. 2017. J Neurochem. 141:347. PubMed
  695. Arber C, et al. 2020. Mol Psychiatry. 25:2919. PubMed
  696. Dementyeva EV, et al. 2021. Stem Cell Research. 53:102348. PubMed
  697. Hung C, et al. 2021. Cell Reports. 35(11):109259. PubMed
  698. Cartoni R, et al. 2016. Neuron. 92(6):1294-1307. PubMed
  699. Schoger E, et al. 2021. Stem Cell Research. 55:102473. PubMed
  700. Valdez C, et al. 2020. Hum Mol Genet. 716:29. PubMed
  701. Tolomeo AM, et al. 2021. Front Cell Neurosci. 602888:15. PubMed
  702. Ornaghi F, et al. 2020. Neurobiol Dis. 134:104667. PubMed
  703. Hackelberg S, et al. 2017. PLoS One. 10.1371/journal.pone.0180427. PubMed
  704. Stepp MA, et al. 2018. Exp Eye Res. 10:113. PubMed
  705. Merten N et al. 2018. Cell chemical biology. 25(6):775-786 . PubMed
  706. Tandon R et al. 2018. Stem cell research. 33:120-124 . PubMed
  707. Kaur T et al. 2018. The Journal of comparative neurology. 526(5):824-835 . PubMed
  708. Lang C et al. 2019. Cell stem cell. 24(1):93-106 . PubMed
  709. Stylianou N, et al. 2019. Oncogene. 38:913. PubMed
  710. Tiihonen J, et al. 2019. Nat Commun. 10:3933. PubMed
  711. Park KK et al. 2017. The Journal of comparative neurology. 525(2):380-388 . PubMed
  712. Chang CH, et al. 2019. Dev Cell. 48:184. PubMed
  713. Hertz NT et al. 2019. Neuron. 103(3):412-422 . PubMed
  714. Angelim MKSC et al. 2018. Glia. 66(11):2470-2486 . PubMed
  715. Wu J et al. 2017. Cell. 168(3):473-486 . PubMed
  716. Ma S et al. 2017. Developmental cell. 41(4):366-381 . PubMed
  717. Sevilla A et al. 2017. Stem Cell Res. 25:217-220 . PubMed
  718. Crouch EE et al. 2015. The Journal of Neuroscience. 35(11):4528-39 . PubMed
  719. Liu Z, et al. 2017. Stem Cells Dev. 26:177. PubMed
  720. Maslon MM, et al. 2019. EMBO J. 38:e101244. PubMed
  721. Steevens AR, et al. 2019. Development. 146:dev170522. PubMed
  722. Liu W, et al. 2019. Invest Ophthalmol Vis Sci. 60:965. PubMed
  723. Lee JH, et al. 2019. Aging (Albany NY). 11:11541. PubMed
  724. Peng XQ, et al. 2020. Front Cell Neurosci. 0.674305556. PubMed
  725. Vicentini FA, et al. 2021. Microbiome. 9:210. PubMed
  726. Díaz-García S, et al. 2021. Acta Neuropathol. 142:985. PubMed
  727. Harbuzariu A, et al. 2022. iScience. 25:104407. PubMed
  728. Karpinski BA, et al. 2022. Dis Model Mech. 15:. PubMed
  729. Cai T, et al. 2021. Cell Reports. 36(2):109337. PubMed
  730. van Helden RWJ, et al. 2021. Stem Cell Research. 53:102374. PubMed
  731. Calado SM, et al. 2021. Stem Cell Research. 53:102302. PubMed
  732. Sepehrimanesh M, et al. 2020. American Journal of Physiology-Cell Physiology. 319(4):C771-C780. PubMed
  733. Li C, et al. 2020. eLife. 9:00. PubMed
  734. Fame R, et al. 2016. J Neurosci. 36: 6403 - 6419. PubMed
  735. Long K, et al. 2016. Nat Commun. 7:10354. PubMed
  736. Hindman HB, et al. 2019. Exp Eye Res. 181:49. PubMed
  737. Aravamudhan P, et al. 2020. PLoS Pathog. 16:e1008380. PubMed
  738. Medeiros CS, et al. 2018. J Refract Surg. 34:790. PubMed
  739. Romer–Seibert JS, et al. 2019. FASEB J. 33:3291. PubMed
  740. Cotton JL et al. 2017. Developmental cell. 43(1):35-47 . PubMed
  741. Lin B et al. 2017. Cell stem cell. 21(6):761-774 . PubMed
  742. Richard E et al. 2018. Stem cell research. 29:143-147 . PubMed
  743. Kano M, et al. 2019. Endocrinology. 160:1701. PubMed
  744. Schreurs RRCE, et al. 2019. Immunity. 50:462. PubMed
  745. Ioannou MS et al. 2019. Curr Protoc Cell Biol. 84(1):e95 . PubMed
  746. Poulopoulos A, et al. 2019. Nature. 565:356. PubMed
  747. Sun Z, et al. 2019. Nat Commun. 10:3892. PubMed
  748. Ding D, et al. 2018. J Otol. 13:115. PubMed
  749. Fan L et al. 2018. eLife. 7 pii: e35242. PubMed
  750. Amrita Pathak et al. 2018. Developmental cell. 46(3):376-387 . PubMed
  751. Marlier Q et al. 2018. Cell Death Discov. 4:43 . PubMed
RRID
AB_2313773 (BioLegend Cat. No. 801213)
AB_2313773 (BioLegend Cat. No. 801201)
AB_2313773 (BioLegend Cat. No. 801202)
Disclaimer

Covered by US patents 5,675,063 and 7,429,487. Sold under license from Epitomics.

Antigen Details

Structure
Tubulin β 3 is a 450 amino acid protein with a molecular mass of ~50 kD.
Distribution

Tissue distribution: central and peripheral nervous system.
Cellular distribution: cytosol, cytoskeleton and nucleus.

Function
Tubulin β 3 is the major constituent of microtubules, and plays a critical role in proper axon guidance and maintenance.
Interaction
Alpha tubulin, kinesin and dynein.
Cell Type
Mature Neurons, Neural Stem Cells
Biology Area
Cell Biology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family
Microtubules
Antigen References

1. Zhao X, et al. 2017. Med Sci Monit. 22: 3915.
2. Lebok P, et al. 2016. Oncol Lett. 11(3):1987.
3. Du J, et al. 2015. BMC Cancer. 15:536. PubMed
4. Rogue DM., et al. 2013. Clin Exp Metastasis. 31(1): 101.
5. Ploussard G, et al. 2010. Cancer Res. 70(22):9253. PubMed

Gene ID
10381 View all products for this Gene ID
UniProt
View information about Tubulin beta-3 on UniProt.org

Related FAQs

If an antibody clone has been previously successfully used in IBEX in one fluorescent format, will other antibody formats work as well?

It’s likely that other fluorophore conjugates to the same antibody clone will also be compatible with IBEX using the same sample fixation procedure. Ultimately a directly conjugated antibody’s utility in fluorescent imaging and IBEX may be specific to the sample and microscope being used in the experiment. Some antibody clone conjugates may perform better than others due to performance differences in non-specific binding, fluorophore brightness, and other biochemical properties unique to that conjugate.

Will antibodies my lab is already using for fluorescent or chromogenic IHC work in IBEX?

Fundamentally, IBEX as a technique that works much in the same way as single antibody panels or single marker IF/IHC. If you’re already successfully using an antibody clone on a sample of interest, it is likely that clone will have utility in IBEX. It is expected some optimization and testing of different antibody fluorophore conjugates will be required to find a suitable format; however, legacy microscopy techniques like chromogenic IHC on fixed or frozen tissue is an excellent place to start looking for useful antibodies.

Are other fluorophores compatible with IBEX?

Over 18 fluorescent formats have been screened for use in IBEX, however, it is likely that other fluorophores are able to be rapidly bleached in IBEX. If a fluorophore format is already suitable for your imaging platform it can be tested for compatibility in IBEX.

The same antibody works in one tissue type but not another. What is happening?

Differences in tissue properties may impact both the ability of an antibody to bind its target specifically and impact the ability of a specific fluorophore conjugate to overcome the background fluorescent signal in a given tissue. Secondary stains, as well as testing multiple fluorescent conjugates of the same clone, may help to troubleshoot challenging targets or tissues. Using a reference control tissue may also give confidence in the specificity of your staining.

How can I be sure the staining I’m seeing in my tissue is real?

In general, best practices for validating an antibody in traditional chromogenic or fluorescent IHC are applicable to IBEX. Please reference the Nature Methods review on antibody based multiplexed imaging for resources on validating antibodies for IBEX.

Go To Top Version: 7    Revision Date: 01/24/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

ProductsHere

Login / Register
Remember me
Forgot your password? Reset password?
Create an Account