- 3A6 (See other available formats)
- Regulatory Status
- HCDM listed
- Other Names
- CD6 ligand, Activated Leukocyte Cell Adhesion Molecule (ALCAM)
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD166, also known as the CD6 ligand or the Activated Leukocyte Cell Adhesion Molecule (ALCAM), is a 100-105 kD transmembrane glycoprotein. It belongs to the Ig superfamily of proteins and expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, and neurons. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. Recently CD166 has also been used as a potential cancer stem cell marker. The antibody reacts with human activated leukocyte cell adhesion molecule (ALCAM).Product Details
- Verified Reactivity
- Reported Reactivity
- African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Cultured human thymic epithelial cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-P, ICC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunohistochemical staining of paraffin-embedded tissue sections and immunofluorescence.1
(PubMed link indicates BioLegend citation)
- Pretzel D, et al. 2011. Arthritis Res. Ther. 13:R64. (IHC, IF, FC)
- Product Citations
AB_2223892 (BioLegend Cat. No. 343902)
- A type I transmembrane glycoprotein belonging to the Ig superfamily of proteins.
CD166 is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, and neurons.
- Play an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development.
- Cell Type
- Epithelial cells, Fibroblasts, Mesenchymal Stem Cells, Monocytes, Neurons, T cells
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Aruffo A, et al. 1997. Immunol Today. 18(10):498
2. Patel DD, et al. 1995. J. Exp. Med. 181:2213
3. Bowen MA, et al. 1995. J. Exp. Med. 181:1563
4. Horst D, et al. 2009. Cancer Invest. 22:1
- Gene ID
- 214 View all products for this Gene ID
- View information about CD166 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD166 Reagents Request Custom Conjugation
|Purified anti-human CD166||3A6||FC,IHC-P,ICC|
|PE anti-human CD166||3A6||FC|
|APC/Fire™ 750 anti-human CD166||3A6||FC|
|PE/Cyanine7 anti-human CD166||3A6||FC|
|PerCP/Cyanine5.5 anti-human CD166||3A6||FC|
|APC anti-human CD166||3A6||FC|
|TotalSeq™-A1015 anti-human CD166||3A6||PG|
|TotalSeq™-D1015 anti-human CD166 Antibody||3A6||PG|
|TotalSeq™-C1015 anti-human CD166||3A6||PG|
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