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FITC anti-human CD157 (BST-1) Antibody

Pricing & Availability
Clone
W21007F (See other available formats)
Regulatory Status
RUO
Other Names
BST1
Isotype
Rat IgG2a, λ
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Product Citations
publications
W21007F_FITC_CD157_Antibody_030122
Human peripheral blood mononuclear cells were stained with anti-human CD14 APC and anti-human CD157 (BST-1) (clone W21007F) FITC (right) or rat IgG2a, λ FITC isotype control (left). Data shown was gated on CD45-positive lymphocytes+monocytes.
  • W21007F_FITC_CD157_Antibody_030122
    Human peripheral blood mononuclear cells were stained with anti-human CD14 APC and anti-human CD157 (BST-1) (clone W21007F) FITC (right) or rat IgG2a, λ FITC isotype control (left). Data shown was gated on CD45-positive lymphocytes+monocytes.
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382103 25 tests 113€
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382104 100 tests 254€
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Description

CD157, also known as Bone Marrow Stromal Cell Antigen 1 (BST1), is a GPI-anchored glycoprotein. It is an ectoenzyme that has both cyclic ADP-ribose hydrolase and ADP-ribosyl cyclase activities. It is prevalently expressed by cells of the myelomonocytic lineage, and modulates adhesion of neutrophils and monocytes to the extracellular matrix. CD157 is expressed in 97% of primary acute myeloid leukemia samples, and is used as a marker for diagnosis of Paroxysmal Nocturnal Hemoglobinuria, a disease caused by intrinsic deficiency of GPI anchors. 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
hCD157 stable transfectant followed by recombinant protein (aa29-293)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
RRID
AB_2941559 (BioLegend Cat. No. 382103)
AB_2941559 (BioLegend Cat. No. 382104)

Antigen Details

Structure
GPI-anchored, ADP-ribosyl cyclase
Distribution

Cell Membrane

Function
ADP-ribosyl cyclase activity. Fibronectin, fibrinogen, laminin-1 and type 1 collagen binding. Hydrolase, Transferase.
Interaction
CD11b/CD18, ECM components
Ligand/Receptor
NAD, NADP
Cell Type
Antigen-presenting cells, Granulocytes, Monocytes
Biology Area
Cell Adhesion, Cell Proliferation and Viability, Innate Immunity
Molecular Family
CD Molecules, Enzymes and Regulators, Innate Immune Signaling
Antigen References
  1. Ortolan E, et al. 2019. Immunology Letters. 205:59-64
  2. Ferrero E, et al. 2017. Sci Rep. 7: 15923.
  3. Kaisho T, et al. 1994. Proc Natl Acad Sci USA. 91:5325-9.
  4. Morone S, et al. 2014. J Biol Chem. 289:15588-601.
Gene ID
683 View all products for this Gene ID
UniProt
View information about CD157 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 02/28/2022

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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