- SA011F11 (See other available formats)
- Regulatory Status
- Other Names
- Chemokine (C-X3-C motif) receptor 1, Fractalkine receptor, GPR13, CCRL1, CMKBRL1, CMKDR1, V28
- Mouse IgG2a, κ
- Ave. Rating
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- Product Citations
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CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Mouse CX3CR1-transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 650™ under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 650™ excites at 405 nm and emits at 645 nm. The bandpass filter 660/20 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 650™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
- Excitation Laser
Violet Laser (405 nm)
- Application Notes
View more applications data for a different format of this clone in our Scientific Poster Library.
- Product Citations
AB_2565999 (BioLegend Cat. No. 149033)
- G-protein coupled receptor, 7 transmembrane regions, 40 kD.
Resident and alternatively activated macrophages (M2), subset of monocytes, dendritic cells (DCs), natural killer cells (NK), subset of memory T cells, mast cells, glial cells, and astrocytes.
- Involved in cell recruitment during inflammation, participates in cell adhesion and extravasation from blood vessels, coreceptor for HIV1.
- CX3CL1 (fractalkine, neurotactin).
- Cell Type
- Astrocytes, Dendritic cells, Macrophages, Mast cells, Microglia, Monocytes, NK cells, T cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Cytokine/Chemokine Receptors, GPCR
- Antigen References
1. Ponzetta A, et al. 2013. J. Immunol. 191:5684.
2. Jacquelin S, et al. 2013. Blood. 122:674.
3. Garcia JA, et al. 2013. J. Immunol. 191:1063.
4. Lee YS, et al. 2013. Cell. 153:413.
5. Shechter R, et al. 2013. Immunity. 38:555.
- Gene ID
- 13051 View all products for this Gene ID
- View information about CX3CR1 on UniProt.org
Related Pages & Pathways
Other FormatsView All CX3CR1 Reagents Request Custom Conjugation
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Purified anti-mouse CX3CR1
Alexa Fluor® 647 anti-mouse CX3CR1
PE anti-mouse CX3CR1
APC anti-mouse CX3CR1
PerCP/Cyanine5.5 anti-mouse CX3CR1
Brilliant Violet 421™ anti-mouse CX3CR1
Brilliant Violet 510™ anti-mouse CX3CR1
FITC anti-mouse CX3CR1
Alexa Fluor® 488 anti-mouse CX3CR1
PE/Dazzle™ 594 anti-mouse CX3CR1
PE/Cyanine7 anti-mouse CX3CR1
Biotin anti-mouse CX3CR1
Brilliant Violet 605™ anti-mouse CX3CR1
Brilliant Violet 785™ anti-mouse CX3CR1
Brilliant Violet 711™ anti-mouse CX3CR1
Brilliant Violet 650™ anti-mouse CX3CR1
Alexa Fluor® 700 anti-mouse CX3CR1
APC/Fire™ 750 anti-mouse CX3CR1
Pacific Blue™ anti-mouse CX3CR1
TotalSeq™-A0563 anti-mouse CX3CR1
TotalSeq™-C0563 anti-mouse CX3CR1
TotalSeq™-B0563 anti-mouse CX3CR1
APC/Cyanine7 anti-mouse CX3CR1 Antibody
PE/Cyanine5 anti-mouse CX3CR1
PE/Fire™ 700 anti-mouse CX3CR1
APC/Fire™ 810 anti-mouse CX3CR1
PE/Fire™ 640 anti-mouse CX3CR1