Purified anti-RIG-1 Antibody

Pricing & Availability
Clone
SS1A (See other available formats)
Regulatory Status
RUO
Other Names
Retinoic acid-inducible gene 1 protein, DEAD-box protein 58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
SS1A_RIG1_Purified_Antibody_WB_012114.jpg
Western blot analysis of extracts from Raw 264.7 cells starved for 20h (lane 1) and starved for 20h and treated with 1 µg/ml LPS for 9h (lane 2) using anti-RIG-1 antibody (clone SS1A).
  • SS1A_RIG1_Purified_Antibody_WB_012114.jpg
    Western blot analysis of extracts from Raw 264.7 cells starved for 20h (lane 1) and starved for 20h and treated with 1 µg/ml LPS for 9h (lane 2) using anti-RIG-1 antibody (clone SS1A).
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635201 25 µg 112 CHF
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Description

RIG-1/DDX58(Retinoic acid-inducible gene 1 protein/ DEAD-box protein 58) is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 and MDA5 (melanoma differentiation-associated gene 5) are key intracellular receptors that sense intracellular viral infection and trigger a signal forinnate antiviral responses including the production of typeI IFN. Clone SS1A has been shown to be useful for western blotting of the mouse RIG-1 protein.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Peptide-KLH, C-terminal end of murine RIG-1
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Wang W, et al. 2016. Proc Natl Acad Sci U S A. 113: 9581 - 9586. PubMed
RRID
AB_940599 (BioLegend Cat. No. 635201)

Antigen Details

Structure
RIG-1 is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD.
Distribution

Cytoplasm.

Function
Involved in innate immune defense against viruses. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 is one of the key intracellular receptors that sense intracellular viral infection and trigger a signal for
Interaction
Cardif
Biology Area
Cell Biology, Transcription Factors
Antigen References

1. Imaizumi T, et al. 2002. Biochem. Biophys. Res. Commun. 292:274
2. Kato H, et al. 2006. Nature 441:101
3. Kato H, et al. 2005. Immunity 23:19

Gene ID
109906 View all products for this Gene ID
UniProt
View information about RIG-1 on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 01.21.2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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