- Clone
- 5-369 (See other available formats)
- Other Names
- ACE, kininase II, dipeptidyl dipeptidase 1, peptidase P, carboxycathepsin
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
GM-CSF-stimulated human peripheral blood mononuclear cells (day-3) were stained with CD143 (clone 5-369) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram). Data shown was gated on CD14+ cell population.
| Cat # | Size | Price | Quantity Avail. | Save | ||
|---|---|---|---|---|---|---|
| 344206 | 100 tests | 275 CHF | ||||
CD143 (ACE, kininase II, peptidyl dipeptidase 1, peptidase P, carboxycathepsin) is a 171 kD, type I, single chain transmembranal metallopeptidase, whose cofactor is zinc. Its main targets are angiotensin I and bradykinin, acting as a blood pressure regulator. CD143 is expressed in endothelial cells; varying amounts of CD143 have been reported in different epithelial cells. The activation of macrophages and histiocytes induces the expression of this molecule.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
- Concentration
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Red Laser (633 nm)
- Product Citations
-
- RRID
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AB_11149487 (BioLegend Cat. No. 344206)
Antigen Details
- Structure
- Single chain, type I transmembranal zinc metallopeptidase, 170 kD.
- Distribution
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Endothelial cells, some types of epithelial cells, activated macrophages and histiocytes.
- Function
- Regulates blood pressure by promoting vasoconstriction by the conversion of angiotensin I to angiotensin II and by the degradation of bradykinin, a vasodilator.
- Ligand/Receptor
- Angiotensin I, bradykinin.
- Bioactivity
- Blood pressure regulator.
- Cell Type
- Endothelial cells, Epithelial cells, Macrophages
- Biology Area
- Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Nakamura T, et al. 2009. Int Heart J. 50:501.
2. Jayasooriya AP, et al. 2008. P. Natl. Acad. Sci. USA 105:6531.
3. Jokubaitis VJ, et al. 2008. Blood 111:4055.
4. Arndt PG, et al. 2006. J. Immunol. 177:7233.
5. Balyasnikova IV, et al. 2002. Biochem J. 362:585. - Gene ID
- 1636 View all products for this Gene ID
- UniProt
- View information about CD143 on UniProt.org
Related Pages & Pathways
Pathways
Related FAQs
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