- H194-112 (See other available formats)
- Regulatory Status
- Other Names
- Dipeptidyl peptidase 4, THAM
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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CD26, also known as DPP IV or THAM, is a 220 kD type II transmembrane homodimer. It consists of an α/β hydrolase domain and an eight-blade beta-propeller domain. After proteolysis of the membrane-bound CD26, a soluble form of DPP IV is released. CD26 is expressed on thymocytes (development dependent), T cells, B cells, NK cells, and macrophages. It is involved in T cell costimulation, endothelial cell migration and proteolysis processes.Product Details
- Antibody Type
- Host Species
- BALB/c thymocytes
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP, IHC-F - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications include: in vitro activation of thymocytes1, immunoprecipitation from cell lysates and cell-free supernatants1,2 and immunohistochemical staining of frozen tissue sections1.
(PubMed link indicates BioLegend citation)
- Product Citations
AB_10567106 (BioLegend Cat. No. 137801)
AB_2093730 (BioLegend Cat. No. 137802)
- Homodimer, each monomer is a single chain type II transmembranal molecule of 110 kD that consists of two domains; soluble form is released after proteolysis of the membrane form
Mature thymocytes, activated T cells, B cells, NK cells, macrophages
- T cell costimulation, endothelial cell migration, proteolysis
- CAV1, IGF2R, PTPRC, BCL10, CARD1, IKBKB
- ADA, collagen
- Cell Type
- B cells, Macrophages, NK cells, T cells, Thymocytes
- Biology Area
- Immunology, Costimulatory Molecules
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Cooper KG, et al. 2009. Infect. Immun. 77:2447.
2. Eltzschig HK, et al. 2006. Blood 108:1602.
3. Peranteau WH, et al. 2006. Blood 108:4268.
- Gene ID
- 13482 View all products for this Gene ID
- View information about CD26 on UniProt.org
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