- 162.1 (See other available formats)
- Regulatory Status
- Other Names
- CD2 like receptor activating cytotoxic cells, CD319, CS1, 19A24
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CD319 is a single-pass type l transmembrane glycoprotein, expressed on NK cells, subsets of mature dendritic cells, activated B cells, and cytotoxic lymphocytes, but not in promyelocytic, B or T cell lines. Expression is highest in the spleen, lymph nodes, and peripheral blood leukocytes, and lowest in bone marrow. Additionally, it is expressed in the small intestine, stomach, appendix, lung, and trachea. CD319 is tyrosine phosphorylated in activated NK cells and is associated with 19 and 39 kD proteins. CD319 has homology with the CD2 family of receptors within the Ig superfamily. Some of the CD2 members stimulate cytotoxicity through the CD319 associated protein.Product Details
- Human, Cynomolgus
- Antibody Type
- Host Species
- CRACC-Human IgG1 fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Bouchon A, et al. 2001. J. Immunol. 167:551721.
- Tassi I and Colonna M. 2005. J. Immunol. 175:79968002.
- Veillette A. 2006. Immunol. Rev. 214:2234.
- Product Citations
AB_961330 (BioLegend Cat. No. 331802)
- Ig superfamily, 66 kD.
NK cells, subsets of mature dendritic cells, activated B cells, cytotoxic lymphocytes but not in promyelocytic, B or T cell lines.
- Regulates T cell and NK cell functions.
- Cell Type
- B cells, Dendritic cells, Lymphocytes, NK cells, Tregs
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Bouchon A, et al. 2001. J. Immunol. 167:551721.
2. Tassi I and Colonna M. 2005. J. Immunol. 175:79968002.
3. Veillette A. 2006. Immunol. Rev. 214:2234.
- Gene ID
- 57823 View all products for this Gene ID
- View information about CD319 on UniProt.org
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