- P84F8 (See other available formats)
- Regulatory Status
- Other Names
- B-Cell CLL/Lymphoma 10, B-Cell Lymphoma/Leukemia 10, Bcl-10, BCL-10, CARD Containing Molecule Enhancing NF-KB, CLAP, Me10, CIPER, c-E10, CARMEN, IMD37
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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BCL10 (B cell lymphoma 10), together with CARMA1 (CARD11) and lymphoid tissue lymphoma-translocation gene 1 (MALT1) are signaling proteins. They have a key role in antigen-receptor-mediated lymphocyte activation through the NF-κB pathway. Activation of NF-κB is essential for the immune system to function normally. Deregulated NF-κB in lymphocytes can lead to immunodeficiency, but also to autoimmunity or lymphomas. Phosphorylation of the CARMA1 and BCL10 proteins and ubiquitylation of BCL10 affect the formation and stability of the CARMA1-BCL10-MALT1 (CBM) complex, and also control negative feedback regulation of the NF-κB signaling pathway. Also, recent studies point out an unexpected role for BCL10 in the regulation of the actin cytoskeleton.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Purified recombinant fragment of human BCL10 expressed in E. Coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Reacts with mouse BCL10.
AB_2572170 (BioLegend Cat. No. 684702)
- 233 amino acids with the predicted molecular weight of approximately 26kD with the characteristic of caspase recruitment domain.
BCL10 is expressed in all normal and malignant tissues. In the lymphoid tissue, it is highly expressed in the germinal center but low in the mantle zone, and intermediate in the marginal zone.
- Antigen-receptor-mediated lymphocyte activation through the NF-κB pathway.
- CARMA1, CARD9, 10 and 14, MALT1, BCR, TCR
- Cell Type
- B cells, Neutrophils
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cancer Biomarkers, Cell Biology, Cell Cycle/DNA Replication, Cell Motility/Cytoskeleton/Structure, Immunology, Innate Immunity, Signal Transduction, Transcription Factors, Ubiquitin/Protein Degradation
- Antigen References
1. Turvey SE, et al. 2014. J. Allergy Clin. Immunol. 134:276.
2. Thome M, et al. 2010. Cold Spring Harb. Perspect. Biol. 2:a003004.
3. Thome M, et al. 2007. Trends Immunol. 28:281.
4. Pérez de Diego R, et al. 2015. J. Allergy Clin. Immunol. 136:1139.
5. Sun W, et al. 2010. Cell Signal. 22:1799.
6. Jost P, et al. 2006. Curr. Drug Targets 7:1335.
7. Lin X, et al. 2004. Semin. Immunol. 16:429.
8. Thome M, et al. 2004. Nat. Rev. Immunol. 4:348.
9. Marion S, et al. 2012. Dev. Cell 5:954-967.
- Gene ID
- 8915 View all products for this Gene ID
- View information about BCL10 on UniProt.org
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