- NKTA255 (See other available formats)
- Regulatory Status
- HCDM listed
- Other Names
- LAIR-1 (Leukocyte-associated Ig-like receptor 1)
- Mouse IgG1
- Ave. Rating
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- Product Citations
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CD305, also known as LAIR-1 (leukocyte-associated Ig-like receptor-1), is a 40 kD type I transmembrane glycoprotein. LAIR-1 and LAIR-2 are the only members of the LAIR family in the Ig superfamily. LAIR-1 is an inhibitory molecule characterized by ITIMs in the cytoplasmic domain and collagen ligands. CD305 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells. LAIR-1 functions in the inhibition of cell cytotoxicity, cell activation, proliferation and differentiation.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Poggi A, et al. 1995. Eur. J. Immunol. 25:369
- Product Citations
AB_1659239 (BioLegend Cat. No. 342801)
AB_2133480 (BioLegend Cat. No. 342802)
- 40 kD type I transmembrane protein, cytoplasmic domain contains ITIM motifs, Ig superfamily
NK cells, T cell, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells
- Inhibition of cell cytotoxicity, cell activation, proliferation and differentiation
- Cell Type
- B cells, Basophils, Dendritic cells, Eosinophils, Macrophages, Mast cells, Monocytes, NK cells, T cells
- Biology Area
- Immunology, Inhibitory Molecules, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
1. Meyaard L, et al. 2008. J. Leukoc. Biol. 83:799
2. Lebbink RJ, et al. 2006. J. Exp. Med. 203:1419
- Gene ID
- 3903 View all products for this Gene ID
- View information about CD305 on UniProt.org
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