Amyloid precursor protein (APP) is a transmembrane protein that is highly expressed in neuronal tissues and enriched at synapses. APP undergoes proteolytic processing through two distinct pathways: 1) the amyloidogenic pathway that generates amyloid beta (Aβ) peptides through sequential processing by β- and γ-secretases, and 2) the non-amyloidogenic pathway, where processing by α-secretase precludes the generation of Aβ. Aberrant processing and accumulation of Aβ peptides leads to the formation of oligomeric and fibrillar aggregates, which interfere with cellular processes and lead to neuronal cell death. The Aβ aggregates are a hallmark of Alzheimer’s disease (AD) and other Aβ-related disorders, and can be used as a tool for pathology detection.
BioLegend’s APP/Aβ Antibody Sampler Kit offers an easy solution for detection of full-length APP and various APP cleavage fragments including Aβ 1-40 and Aβ 1-42 peptides.