- A15165E (See other available formats)
- Regulatory Status
- Other Names
- PARK2, AR-JP, LPRS2, PDJ, PRKN, E3 ubiquitin-protein ligase parkin, Parkin 2, E3 ubiquitin ligase, parkinson disease protein 2, parkinson juvenile disease protein 2, Parkinson disease (autosomal recessive, juvenile) 2
- Mouse IgG2b, κ
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- Product Citations
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Parkin (also known as PARK2, AR-JP, PRKN) is a protein encoded by the PARK2 gene in humans. It is a component of the E3 ubiquitin ligase complex that mediates the targeting of proteins for degradation. Mutations in the PARK2 gene cause a familial form of Parkinson’s disease called autosomal recessive juvenile parkinsonism (AR-JP).Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant full-length human Parkin protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 2 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2820192 (BioLegend Cat. No. 870401)
AB_2820193 (BioLegend Cat. No. 870402)
- Human Parkin is a 465 amino acid protein with a predicted molecular mass of ~52 kD.
Tissue distribution: Brain, heart, testis, and skeletal muscle
Cellular distribution: Cytosol, mitochondria, nucleus, and endoplasmic reticulum
- Parkin is involved in protein ubiquitination, protein degradation, mitochondria function, and neurodegeneration.
- Ubiquitin, PINK1
- BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1
- Cell Type
- Biology Area
- Cell Biology, Mitochondrial Function, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Protein Misfolding and Aggregation, Protein Trafficking and Clearance, Ubiquitin/Protein Degradation
- Molecular Family
- Antigen References
- Tay SP, et al. 2010. J Biol Chem. 285: 29231-8.
- Pawlyk AC, et al. 2003. J Biol Chem. 278(48):48120-8.
- Gene ID
- 5071 View all products for this Gene ID
- View information about Parkin on UniProt.org
Related Pages & Pathways
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