- L24/18 (See other available formats)
- Other Names
- Inositol 1,4,5-trisphosphate receptor type 1, IP-3-R, IP3R 1, IP3 receptor, type 1 InsP3 receptor, inositol 1,4,5-triphosphate receptor 1, inositol 1,4,5-triphosphate receptor, type 1, type 1 inositol 1,4,5-trisphosphate receptor
Covance Catalog# MMS-5151
- Mouse IgG1
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Inositol 1,4,5-triphosphate (IP3) is a calcium-regulating second messenger that receptor involved in ER stress-induced apoptosis. IP3 receptor, type 1 (IP3R1) is a receptor for IP3 expressed on the ER which opens a calcium channel on the ER after IP3 bidning. IP3R1 is expressed in developing and mature neurons and its dysregulation may be involved in progression of certain neurodegenerative diseases. IP3R1 is also involved in autophagy, cellular energenetics, macrophage inflammasomes, and other cellular processes.Product Details
- Human, Mouse, Rat
- Host Species
- This monoclonal antibody was raised against a fusion protein corresponding to amino acids 2680-2749 of rat IP3 receptor type 1.
- Phosphate-buffered solution.
- The antibody was purified by affinity chromatography.
- 1 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
- Recommended Usage
Each lot of this antibody is quality control tested by immunohistochemical staining.
The optimal working dilution should be determined for each specific assay condition.
• WB: 1-10 µg/ml
• IHC: 1-10 µg/ml
- Application Notes
This antibody is effective in immunoblotting (WB) and immunohistochemistry (IHC).
This antibody is less reactive in human samples than mouse and rat sample in WB.
(PubMed link indicates BioLegend citation)
- Zhao G, et al. 2010. J. Gen. Physiol. 136(3):283-91 (WB)
- Watanabe S, et al. 2016. EMBO Mol Med. 8(12):1421-1437. PubMed
AB_2564813 (BioLegend Cat. No. 817701)
- IP3R1 is a 2758 amino acid protein with an apparent molecular mass of 314 kD.
Cellular distribution: Plasma membrane, endoplasmic reticulum, and nucleus.
- Antigen References
Tang T-S, et al. 2009. J. Neurosci. 29 (5) 1257-66.
- Gene ID
- 25262 View all products for this Gene ID
- View information about IP3R1 on UniProt.org
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