- 8F11-M16 (See other available formats)
- Regulatory Status
- Other Names
- Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. Binding of ligand to CXCR7 induces proliferation and migration of immature neurons, glia and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells. Surface expression of CXCR7 was also reported to be on tumor cells, activated endothelial cells, fetal liver cells, and other cell types.Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Host Species
- Human CXCR7 transfectant
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2 µg per million cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Product Citations
AB_2089777 (BioLegend Cat. No. 331102)
- G protein-coupled receptor super family
Monocytes, B cells, T cells and mature dendritic cells
- CXCL12/SDF-1 and CXCL11/I-TAC
- Cell Sources
- On a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells
- Cell Type
- B cells, Dendritic cells, Monocytes, T cells
- Biology Area
- Molecular Family
- Cytokine/Chemokine Receptors, GPCR
- Antigen References
1. Burns JM, et al. 2006. J. Exp. Med. 203:2201.
2. Infantino S, et al. 2006. J. Immunol. 176:2197.
- Regulates the trafficking and activation of leukocytes
- Gene ID
- 12778 View all products for this Gene ID 57007 View all products for this Gene ID
- View information about CXCR7 on UniProt.org
Related Pages & Pathways
- Does staining at room temperature or even at 37°C help for checking chemokine receptors expression?
Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal.
Other FormatsView All CXCR7 Reagents Request Custom Conjugation
|Purified anti-human/mouse CXCR7||8F11-M16||FC|
|PE anti-human/mouse CXCR7||8F11-M16||FC|
|Biotin anti-human/mouse CXCR7||8F11-M16||FC|
|APC anti-human/mouse CXCR7||8F11-M16||FC|
|PE/Cyanine7 anti-human/mouse CXCR7||8F11-M16||FC|
|PE/Dazzle™ 594 anti-human/mouse CXCR7||8F11-M16||FC|
|PerCP/Cyanine5.5 anti-human/mouse CXCR7||8F11-M16||FC|
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