Purified anti-human CD323 (JAM3) Antibody

Pricing & Availability
Clone
SHM33 (See other available formats)
Other Names
JAM-C, Jcam3
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
SHM33_Purified_CD323_Antibody_FC_011713
Human melanoma cell line, A375, was stained with purified CD323 (clone SHM33, filled histogram) or mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG PE.
  • SHM33_Purified_CD323_Antibody_FC_011713
    Human melanoma cell line, A375, was stained with purified CD323 (clone SHM33, filled histogram) or mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG PE.
Cat # Size Price Quantity Avail. Save
356701 25 µg $95
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356702 100 µg $245
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Description

CD323, also known as JAM3 and JAM-C, is a member of the junctional adhesion molecule family and plays a role in leukocyte migration.  It is a type I transmembrane protein and is involved in cell-cell adhesion by forming homotypic or heterotypic molecules with JAM family members or integrins.  CD323 is expressed in intestinal epithelial cells and is a component of epithelial desmosomes, endothelial cells, and platelets.  It is expressed at low levels on T cells and is upregulated upon activation.  Due to their presence in tight junction and lateral membranes, JAMs are candidate receptors for leukocytes to use when they migrate.  Thrombin induces localization of JAM3 in the tight junctions, whereas angiopoietin-1 prevents JAM3 localization.

Product Details
Technical data sheet

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2561800 (BioLegend Cat. No. 356701)
AB_2561801 (BioLegend Cat. No. 356702)

Antigen Details

Structure
42 kD, type I transmembrane protein, immunoglobulin superfamily
Distribution
Intestinal epithelial cells, epithelia desmosomes, peripheral B cells, endothelial cells, platelets and a subset of T cells
Function
Leukocyte migration
Interaction
Integrins
Cell Type
Epithelial cells, B cells, Endothelial cells, Platelets, T cells
Biology Area
Cell Adhesion, Cell Biology, Immunology
Molecular Family
CD Molecules
Gene ID
83700 View all products for this Gene ID
UniProt
View information about CD323 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 02/13/2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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