- QA21A08 (See other available formats)
- Regulatory Status
- Other Names
- S152, T14, TNFRSF7
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD27 is a 50-55 kD type I membrane protein also known as S152 and T14. It is a lymphocyte-specific member of the TNF-receptor superfamily. CD27 is expressed on medullary thymocytes, virtually all mature T cells, some B cells, and NK cells. CD27 binds to CD70, and plays a role in costimulation of T cell activation and regulation of B cell differentiation and proliferation. The cytoplasmic domains of CD27 have also been shown to interact with TRAF2 and TRAF5 to elicit NF-κB and SAPK/JNK activation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- PBS, pH 7.2, containing 50mM sodium citrate and 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Clone QA21A08 can completely block the binding of clone M-T271 on target cells.
AB_2922616 (BioLegend Cat. No. 382502)
- TNF-R superfamily, type I transmembrane glycoprotein, 50-55 kD
Medullary thymocytes, T and B cell subsets, NK cells
- TRAF2, TRAF5
- Cell Type
- B cells, NK cells, T cells, Thymocytes
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
- Knapp W, et al. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press.
- Schlossman S, et al. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press.
- Hintzen RQ, et al. 1994. Immunol Today. 15:307-11.
- Agematsu K, et al. 1995. J Immunol. 154:3627-35.
- Gene ID
- 939 View all products for this Gene ID
- View information about CD27 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD27 Reagents Request Custom Conjugation
|Purified anti-human CD27 Recombinant Antibody||QA21A08||FC|
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