- O93F3 (See other available formats)
- Other Names
- ATG6 Autophagy Related 6 Homolog, VSP30
- Mouse IgG1
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- Product Citations
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Beclin-1 plays a central role in autophagy and is involved in autophagosome formation. It acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Beclin-1 is necessary for the initiation of autophagy, and it has been shown to be reduced in the brains of patients with Alzheimer’s disease. Reduced Beclin-1 levels lead to decreased autophagy, the accumulation of Aβ peptides, and neurodegeneration in mouse models of Alzheimer's disease.Product Details
- Human, Rat, Mouse
- Antibody Type
- Host Species
- Full length recombinant human Beclin-1 protein (NP_003757) produced in HEK293T cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 5.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Deng X, et al. 2017. Biochim. Biophys. Acta. 1862(3):337-350 (WB).
AB_2687306 (BioLegend Cat. No. 849701)
AB_2687307 (BioLegend Cat. No. 849702)
- Beclin-1 is a 450 amino acid protein with a molecular mass of 52 kD.
Tissue distribution: Beclin-1 is ubiquitously expressed. </br>Cellular distribution: Cytosol, endoplasmic reticulum, endosome, mitochondria, and nucleus.
- Beclin-1 is involved in autophagosome formation in autophagy.
- Beclin-1 interacts with Bcl-2 and PI3K class III.
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Neuroscience Cell Markers, Protein Trafficking and Clearance
- Molecular Family
- Autophagosome Markers
- Antigen References
- Cao Y, et al. 2007. Cell. Research 17:839.
- Gene ID
- 8678 View all products for this Gene ID
- View information about Beclin-1 on UniProt.org
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