- 5D3 (See other available formats)
- Regulatory Status
- HCDM listed
- Other Names
- ABCG2, CDw338, Bcrp1, MXR
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CD338, known as ABCG2 (BCRP1), is a multi-drug resistance (MDR) family protein that is a member of ATP binding cassette (ABC) transporters. It is highly expressed on primitive ‘side population’ (SP) stem cells. This SP phenotype is based on the efflux of fluorescent dyes such as Rhodamine 123 and Hoechst 33342. The SP cells express low or undetectable levels of CD34. In the bone marrow, about 0.05% population of cells displays the low fluorescence and are highly enriched for repopulating cells. The highest levels of BCRP1 mRNA expression have been seen in KDR+ human stem cells. The expression of ABCG2 appears to be highly conserved as it has been identified in various species.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
This clone is listed under the following US Patent Numbers:
6,313,277; 7,541,437; 7,655,755; 7,741,455
(PubMed link indicates BioLegend citation)
- Product Citations
AB_1227470 (BioLegend Cat. No. 332020)
primitive 'sidepopulation' (SP) stem cells, KDR+ human stem cells
- Cell Type
- Embryonic Stem Cells, Hematopoietic stem and progenitors, Neural Stem Cells
- Biology Area
- Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells
- Molecular Family
- CD Molecules
- Antigen References
1. Kim M, et al. 2002. Clin. Cancer Res. 8:228.
2. Scharenber CW, et al. 2002. Blood 99:50712.
3.Goodell MA, et al. 1997. Nat. Med. 3:133745.
4. Bunting KD. 2002. Stem Cells. 20:11.
- Gene ID
- 9429 View all products for this Gene ID
- View information about CD338 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD338 Reagents Request Custom Conjugation
|PE anti-human CD338 (ABCG2)||5D3||FC|
|FITC anti-human CD338 (ABCG2)||5D3||FC|
|APC anti-human CD338 (ABCG2)||5D3||FC|
|PerCP/Cyanine5.5 anti-human CD338 (ABCG2)||5D3||FC|
|PE/Cyanine7 anti-human CD338 (ABCG2)||5D3||FC|
|TotalSeq™-C0569 anti-human CD338 (ABCG2)||5D3||PG|
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