APC anti-human CD271 (NGFR) Antibody

Pricing & Availability
ME20.4 (See other available formats)
Regulatory Status
Other Names
p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, NGFR, Nerve Growth Factor Receptor
Mouse IgG1, κ
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Product Citations
Human neuroblastoma cell line, SK-N-MC, stained with ME20.4 APC
  • ME20dot4_APC_040810
    Human neuroblastoma cell line, SK-N-MC, stained with ME20.4 APC
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345107 25 tests 124€
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345108 100 tests 261€
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CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Host Species
WM245 melanoma cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications for the relevant formats include: immunoprecipitation1, Western blotting4, immunohistochemical staining of frozen or paraffin embedded tissue sections1,2, and blocking of NGF binding1.

Application References
  1. Ross A, et al. 1984. P. Natl. Acad. Sci. USA 81:6681. (FC, IP, Block, IHC)
  2. Cattoretti G, et al. 1993. Blood 81:1726. (IHC)
  3. Kamke MR, et al. 2005. Hear Res. 206:89.
  4. Baker D, et al. 1989. Cancer Res. 49:4142-4146. (FC, WB)
Product Citations
  1. Torre E et al. 2018. Cell systems. 6(2):171-179 . PubMed
  2. Torre EA, et al. 2021. Nat Genet. 53:76. PubMed
  3. Peng K, et al. 2020. Sci Rep. 10:18433. PubMed
  4. Fahl SP, et al. 2018. J Immunol. 200:3450. PubMed
  5. Giambra V et al. 2018. Cell stem cell. 23(5):714-726 . PubMed
  6. Gu P, et al. 2016. Oncogene. 10.1038/onc.2016.405. PubMed
  7. Greenwood EJD et al. 2019. Cell Rep. 27(5):1579-1596 . PubMed
  8. Berical A, et al. 2022. Nat Commun. 13:4270. PubMed
  9. Brun J, et al. 2015. PLoS One. 10: 0145153. PubMed
  10. Leibel SL, et al. 2022. iScience. 25:103797. PubMed
  11. Duan X, et al. 2022. Cell Biosci. 12:60. PubMed
  12. Kumar B, et al. 2022. Sci Adv. 8:eabh3375. PubMed
  13. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  14. Portillo AL, et al. 2021. STAR Protoc. 2:100956. PubMed
  15. Stowe CL, et al. 2019. eLife. 0.333333333333333. PubMed
  16. Jiang M, et al. 2021. Developmental Cell. 56(11):1646-1660.e5. PubMed
  17. Bazot Q, et al. 2014. Nucleic Acids Res. 42:9700. PubMed
  18. Loo CS, et al. 2020. Immunity. 53:143. PubMed
  19. Barbarani G, et al. 2019. Sci Rep. 9:3388. PubMed
  20. Shalabi SF, et al. 2021. Nat Aging. 1:838. PubMed
  21. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  22. Kumar B, et al. 2018. Cancer Res. 78:5107. PubMed
  23. Hawkins FJ, et al. 2020. Cell Stem Cell. 28(1):79-95.e8. PubMed
  24. Shin B, et al. 2020. Cell Rep. 1898:30. PubMed
  25. Hu Y, et al. 2016. J Exp Med. 213: 2759 - 2772. PubMed
  26. Rodrigues Toste de Carvalho AL, et al. 2021. Nat Protoc. 16:1802. PubMed
  27. Portillo AL, et al. 2021. iScience. 24(6):102619. PubMed
  28. Boshuizen J, et al. 2020. Nat Commun. 3.198611111. PubMed
AB_10639737 (BioLegend Cat. No. 345107)
AB_10645515 (BioLegend Cat. No. 345108)

Antigen Details

Type I transmembranal protein with a MW of 75 kD. The extracellular portion contains four TNFR-Cys repeats that form the NGF binding domain; the intracellular portion contains a death domain.

Expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells, melanocytes.

Apoptosis, differentiation, neurogenesis.
Nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF), Neurotrophin 3. (NTF3) , Neurotrophin 4 (NTF4)
Apoptosis, differentiation, neurogenesis.
Cell Type
Dendritic cells, Mesenchymal cells, Mesenchymal Stem Cells, Neurons
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, Postsynaptic proteins
Antigen References

1. Friedman MJ, et al. 2009. J. Biol. Chem. 284:27944.
2. Rock JR, et al. 2009. Proc Natl Acad Sci USA. 106:12771.
3. Kidd SK, et al. 2008. Brain Res.1195:113.
4. Peters EM, et al. 2007. Am J Pathol. 171:1872.
5. Jansen P, et al. 2007. Nat Neurosci. 10:1449.

Gene ID
4804 View all products for this Gene ID
View information about CD271 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/30/2012

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD271 (NGFR)

  • FITC anti-human CD271 (NGFR)

  • PE anti-human CD271 (NGFR)

  • APC anti-human CD271 (NGFR)

  • PE/Cyanine7 anti-human CD271 (NGFR)

  • PerCP/Cyanine5.5 anti-human CD271 (NGFR)

  • Alexa Fluor® 647 anti-human CD271 (NGFR)

  • Alexa Fluor® 700 anti-human CD271 (NGFR)

  • PE/Dazzle™ 594 anti-human CD271 (NGFR)

  • APC/Fire™ 750 anti-human CD271 (NGFR)

  • Biotin anti-human CD271 (NGFR)

  • TotalSeq™-A0816 anti-human CD271 (NGFR)

  • APC/Cyanine7 anti-human CD271 (NGFR)

  • TotalSeq™-C0816 anti-human CD271 (NGFR)

  • TotalSeq™-B0816 anti-human CD271 (NGFR)

  • Pacific Blue™ anti-human CD271 (NGFR) Antibody

  • TotalSeq™-D0816 anti-human CD271 (NGFR)


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