- Poly28637 (See other available formats)
- Other Names
- Adenosine Deaminase, Adenosine Aminohydrolase, EC 188.8.131.52, ADA1
- Rabbit Polyclonal IgG
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Adenosine Deaminase (ADA) is an enzyme that catalyzes hydrolytic deamination of adenosine and 2-deoxyadenosine. It is involved in purine metabolism, and plays an important role in adenosine homeostasis. ADA can also function as a positive regulator of T-cell coactivation and lymphocyte-epithelial cell adhesion. Mutations in ADA are linked to various human diseases, including autosomal recessive Omenn syndrome and congenital hemolytic anemia.Product Details
- Antibody Type
- Host Species
- Recombinant Adenosine Deaminase expressed in E.coli.
- 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
WB - Quality tested
IHC-P - Validated
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- ADA is a 363 amino acid protein with predicted molecular mass of ~41 kD and observed molecular mass of ~41 kD.
Tissue Distribution: Spleen, T-cells, lymphocytes, and monocytes
Cellular Distribution: Cytosol
- ADA is involved in purine metabolism and adenosine homeostasis. It also functions as a positive regulator of T-cell coactivation and lymphocyte-epithelial cell adhesion.
- DPP4, ADORA1, ADORA2A
- Cell Type
- B cells, Lymphocytes, NK cells, T cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Innate Immunity
- Molecular Family
- Enzymes and Regulators, Innate Immune Signaling
- Antigen References
- Bradford KL, et al. 2017. J Clin Immunol. 37(7):626.
- Samuel CE. 2019. J Biol Chem. 294(5):1710.
- Gene ID
- 100 View all products for this Gene ID 11486 View all products for this Gene ID 25367 View all products for this Gene ID
- View information about Adenosine Deaminase on UniProt.org
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