- HSL11 (See other available formats)
- Other Names
- Ig Lambda 5, λ5, Ig omega
- Mouse IgG1, κ
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- Product Citations
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CD179b, also known as Ig Lambda 5, λ5, and Ig omega, is a 22 kD, C-like protein member within the Ig superfamily. λ5 associates with CD179a (VpreB) to form a surrogate light (SL) chain that in turn associates with the IgM heavy chain and the CD79a/CD79b heterodimer to form the pre-B cell receptor (PreBCR) complex. The function of CD179a/CD179b is still under investigation, though it has been reported that the deficiency of CD179a and/or CD179b impairs the maturation of the B cell precursors beyond the pre-B cell stage.Product Details
- Human, African Green
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
ICFC, IHC-P, IHC-F, IP - Reported in the literature
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation1 and immunohistochemistry of frozen and paraffin-embedded samples2.
(PubMed link indicates BioLegend citation)
- Tsyganezawa K, et al. 1998. Blood 92:4317. (IP)
- Kiyokawa N, et al. 2004. Modern Pathol. 17:423. (ICFC, IHC)
AB_10644164 (BioLegend Cat. No. 349802)
- Immunoglobine (Ig) V-like protein. Molecular weight 22 kD. Associates with CD179a (VpreB) to form the surrogate light (SL) chain, which binds to the the Ig µ heavy chain and CD79a/CD79b heterodimer complex to form the pre-B cell receptor (preBCR).
Pro-B and early Pre-B cells
- Cell Type
- B cells
- Biology Area
- Cell Biology, Immunology, Signal Transduction, Costimulatory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc.
2. Zhang M, et al. 2004. Cell. Mol. Immunol. 1:89.
3. Hendriks RW and Middendorp S. 2004. Trends Immunol. 25:249.
- Gene ID
- 3543 View all products for this Gene ID
- View information about CD179b on UniProt.org
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