Purified anti-human CD179b (Ig λ5) Antibody

Pricing & Availability
HSL11 (See other available formats)
Other Names
Ig Lambda 5, λ5, Ig omega
Mouse IgG1, κ
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Product Citations
Human cell lines REH (pro-B, blue), NALM-6 (pre-B, orange) and Ramos (B cell, open) stained with purified HSL11 conjugated with PE
  • HSL11_PE_081210
    Human cell lines REH (pro-B, blue), NALM-6 (pre-B, orange) and Ramos (B cell, open) stained with purified HSL11 conjugated with PE
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349802 100 µg 120€
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CD179b, also known as Ig Lambda 5, λ5, and Ig omega, is a 22 kD, C-like protein member within the Ig superfamily. λ5 associates with CD179a (VpreB) to form a surrogate light (SL) chain that in turn associates with the IgM heavy chain and the CD79a/CD79b heterodimer to form the pre-B cell receptor (PreBCR) complex. The function of CD179a/CD179b is still under investigation, though it has been reported that the deficiency of CD179a and/or CD179b impairs the maturation of the B cell precursors beyond the pre-B cell stage.

Product Details
Technical data sheet

Product Details

Human, African Green
Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested
ICFC, IHC-P, IHC-F, IP - Reported in the literature

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation1 and immunohistochemistry of frozen and paraffin-embedded samples2.

Application References

(PubMed link indicates BioLegend citation)
  1. Tsyganezawa K, et al. 1998. Blood 92:4317. (IP)
  2. Kiyokawa N, et al. 2004. Modern Pathol. 17:423. (ICFC, IHC)
AB_10644164 (BioLegend Cat. No. 349802)

Antigen Details

Immunoglobine (Ig) V-like protein. Molecular weight 22 kD. Associates with CD179a (VpreB) to form the surrogate light (SL) chain, which binds to the the Ig µ heavy chain and CD79a/CD79b heterodimer complex to form the pre-B cell receptor (preBCR).

Pro-B and early Pre-B cells

Cell Type
B cells
Biology Area
Cell Biology, Costimulatory Molecules, Immunology, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc.
2. Zhang M, et al. 2004. Cell. Mol. Immunol. 1:89.
3. Hendriks RW and Middendorp S. 2004. Trends Immunol. 25:249.

Gene ID
3543 View all products for this Gene ID
View information about CD179b on UniProt.org

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Go To Top Version: 1    Revision Date: 11.30.2012

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