Analyte Specific Reagent. Analytical and performance characteristics are not established.
- Other Names
- T44, Tp44
- Mouse IgG1, κ
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CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major costimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.Product Details
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
- 100 µg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C and protected from prolonged exposure to light. Do not freeze.
Suggested for Flow Cytometry
WARNINGS AND PRECAUTIONS
- Use appropriate personal protective equipment and safety practices per universal precautions when working with this reagent. Refer to the reagent safety data sheet.
- This antibody contains sodium azide. Follow federal, state and local regulations to dispose of this reagent. Sodium azide build-up in metal wastepipes may lead to explosive conditions; if disposing of reagent down wastepipes, flush with water after disposal.
- All specimens, samples and any material coming in contact with them should be considered potentially infectious and should be disposed of with proper precautions and in accordance with federal, state and local regulations.
- Do not use this reagent beyond the expiration date stated on the label.
- Do not use this reagent if it appears cloudy or if there is any change in the appearance of the reagent as these may be indication of possible deterioration.
- Avoid prolonged exposure of the reagent or stained cells to light.
- Antigen References
- Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York.
- June CH, et al. 1994. Immunol. Today 15:321.
- Linskey PS, et al. 1993. Annu. Rev. Immunol. 11:191.
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