Purified anti-mouse GITR Ligand Antibody

Pricing & Availability
YGL 386 (See other available formats)
Regulatory Status
Other Names
Rat IgG1, κ
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Product Citations
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120302 200 µg 200,00€
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GITR ligand (GITRL) is a member of the TNF superfamily, also known as TNFSF18 or TL6. It is expressed on B cells, macrophages, dendritic cells and endothelial cells. The expression of GITRL on dendritic cell surface can be transiently up-regulated and then rapidly down-regulated by LPS stimulation. GITRL binds to its receptor, GITR, to co-stimulate T cell activation, proliferation, and cytokine production, and inhibit the suppressive functions of CD4+CD25+ Treg cells, as well as induce macrophages activation. GITR-GITRL interaction has been implicated as an essential regulator of immune response to self antigens and phathogens.

Product Details
Technical Data Sheet (pdf)

Product Details

Antibody Type
Host Species
Recombinant mouse GITRL protein and Transfected cells
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059
  2. Lu LF, et al. 2005. J. Immunol. 175:1651
  3. Esparza EM and RH Arch. 2005. J. Immunol. 174:7875
  4. Ray A, et al. 2012. J. Immunol. 188:3188. PubMed.
AB_2207249 (BioLegend Cat. No. 120302)

Antigen Details

TNF superfamily member

B cells, macrophages, dendritic cells, endothelial cells.

Bind GITR receptor to co-stimulate T cells activation, proliferation, and cytokine production; inhibit the suppressive activities of CD4+CD25+ Treg cells.
Cell Type
B cells, Dendritic cells, Endothelial cells, Macrophages, Tregs
Biology Area
Antigen References

1. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059.
2. Kim JD, et al. 2003. Genes Immun. 4:564.
3. Yu KY, et al. 2003. Biochem. Biophys. Res. Commun. 310:433.
4. Shin HH, et al. 2002. Cytokine 19:187.

Gene ID
240873 View all products for this Gene ID
View information about GITRL on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.30.2012

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