- YGL 386 (See other available formats)
- Regulatory Status
- Other Names
- AITRL, TNFSF18, TL6, GITRL
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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GITR ligand (GITRL) is a member of the TNF superfamily, also known as TNFSF18 or TL6. It is expressed on B cells, macrophages, dendritic cells and endothelial cells. The expression of GITRL on dendritic cell surface can be transiently up-regulated and then rapidly down-regulated by LPS stimulation. GITRL binds to its receptor, GITR, to co-stimulate T cell activation, proliferation, and cytokine production, and inhibit the suppressive functions of CD4+CD25+ Treg cells, as well as induce macrophages activation. GITR-GITRL interaction has been implicated as an essential regulator of immune response to self antigens and phathogens.Product Details
- Antibody Type
- Host Species
- Recombinant mouse GITRL protein and Transfected cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059
- Lu LF, et al. 2005. J. Immunol. 175:1651
- Esparza EM and RH Arch. 2005. J. Immunol. 174:7875
- Ray A, et al. 2012. J. Immunol. 188:3188. PubMed.
AB_2207249 (BioLegend Cat. No. 120302)
- TNF superfamily member
B cells, macrophages, dendritic cells, endothelial cells.
- Bind GITR receptor to co-stimulate T cells activation, proliferation, and cytokine production; inhibit the suppressive activities of CD4+CD25+ Treg cells.
- GITR (TNFRSF18)
- Cell Type
- B cells, Dendritic cells, Endothelial cells, Macrophages, Tregs
- Biology Area
- Antigen References
1. Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059.
2. Kim JD, et al. 2003. Genes Immun. 4:564.
3. Yu KY, et al. 2003. Biochem. Biophys. Res. Commun. 310:433.
4. Shin HH, et al. 2002. Cytokine 19:187.
- Gene ID
- 240873 View all products for this Gene ID
- View information about GITRL on UniProt.org
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