- Ba160 (See other available formats)
- Regulatory Status
- Other Names
- CD200 R3, CD200RLb, OX-2 Receptor 3, CD200 receptor 3
- Rat IgG2b, κ
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- Product Citations
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CD200R3, also known as CD200RLb and OX-2 Receptor 3, is a disulfide-linked dimmeric CD200R-like receptor which belongs to immunoglobulin superfamily. Its positively charged aminio acid lysinein associates with ITAM- or YxxM motif-bearing adaptor molecules such as DAP12, DAP10, FcRγ, and CD3ζ. CD200R3 functions as an activating receptor to regulate IgE independent immune response.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Mouse primary basophils
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
Depletion - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Ba160 recognizes circulating and bone marrow basophils; it also recognizes a subset of mast cells in the peritoneal cavity and skin.
A single intravenous administration of 30 µg of LEAF Ba160 to mice induces a dramatic reduction of basophil number in peripheral blood from day 1 to day 10. *Tested in the development stage.
AB_10915471 (BioLegend Cat. No. 142302)
- Immunoglobulin superfamily; disulfide-linked dimmer with positively charged amino acids in transmembrane; molecular weight is about ~38 kD or ~74 kD (reduced or non-reduced condition, respectively).
Basophils in peripheral blood, bone marrow, spleen: mast cells in peritoneal cavity and skin.
- Transduce stimulatory signals.
- DAP12, DAP10, FcRγ, or CD3ζ
- Cell Type
- Basophils, Mast cells
- Biology Area
- Immunology, Inhibitory Molecules
- Molecular Family
- CD Molecules
- Antigen References
1. Voehringer D, et al. 2004. J. Biol. Chem. 52:54117.
2. Kojima T, et al. 2007. J. Immunol. 179:7093.
3. Sato K, et al. 2009. Blood 113:4780.
- Gene ID
- 74603 View all products for this Gene ID
- View information about CD200R3 on UniProt.org
|Purified anti-mouse CD200R3||Ba160||FC, Depletion|
|PE anti-mouse CD200R3||Ba160||FC|
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