- 8F11-M16 (See other available formats)
- Regulatory Status
- Other Names
- Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. Binding of ligand to CXCR7 induces proliferation and migration of immature neurons, glia and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells. Surface expression of CXCR7 was also reported to be on tumor cells, activated endothelial cells, fetal liver cells, and other cell types.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Human CXCR7 transfectant
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
ICFC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2 µg per million cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: Intracellular staining for flow cytometry.2
(PubMed link indicates BioLegend citation)
- Product Citations
AB_2089777 (BioLegend Cat. No. 331102)
- G protein-coupled receptor super family
Monocytes, B cells, T cells and mature dendritic cells
- CXCL12/SDF-1 and CXCL11/I-TAC
- Cell Sources
- On a wide variety of tissues and cells including monocytes, B cells, T cells and mature dendritic cells
- Cell Type
- B cells, Dendritic cells, Monocytes, T cells
- Biology Area
- Molecular Family
- Cytokine/Chemokine Receptors, GPCR
- Antigen References
1. Burns JM, et al. 2006. J. Exp. Med. 203:2201.
2. Infantino S, et al. 2006. J. Immunol. 176:2197.
- Regulates the trafficking and activation of leukocytes
- Gene ID
- 12778 View all products for this Gene ID 57007 View all products for this Gene ID
- View information about CXCR7 on UniProt.org
- Does staining at room temperature or even at 37°C help for checking chemokine receptors expression?
Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal.
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