- 14D2C43 (See other available formats)
- Regulatory Status
- Other Names
- ARG1, Liver Arginase, Type 1 Arginase, Arginase-1, Liver-Type Arginase
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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Arginase I, also known as ARG1, is a 34.7kD protein expressed by neutrophils and myeloid-derived suppressor cells (MDSCs). There are two isoforms that are differentiated based on their tissue distribution and subcellular localization. Arginase I converts L-arginine into L-ornithine and urea; it is the final enzyme in the urea cycle. While mostly found in the liver, it can also be expressed in cells lacking a comprehensive urea cycle. Also, it contributes to vasodilation and vascular function. Arginase I is also reported to be involved in MDSC mediated suppression of T cell proliferation. Arginase I has been implicated in hyperargininemia (decreased function of arginase I) and Q fever.Product Details
- Antibody Type
- Host Species
- Full length recombinant protein expressed in E.coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
ICFC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2571897 (BioLegend Cat. No. 369701)
AB_2571898 (BioLegend Cat. No. 369702)
- Belongs to the ureohydrolase family and has a molecular mass of 34.7 kD.
- Neutrophils and myeloid-derived suppressor cells (MDSC).
- Converts L-arginine into L-ornithine and urea.
- Cell Type
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- Enzymes and Regulators
- Antigen References
1. Munder M, et al. 2005. Blood 105:2549.
2. Luckner-Minden C, et al. 2010. JLB. 87:1125.
3. Holowatz L, et al. 2006. Journal of Physiology 574:573.
4. Sin YY, et al. 2013. PLoS One 8:11.
5. Benoit M, et al. 2008. Eur. J. Immunol. 4:1065.
- Gene ID
- 383 View all products for this Gene ID
- View information about Arginase I on UniProt.org
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