- 14D2C43 (See other available formats)
- Regulatory Status
- Other Names
- ARG1, Liver Arginase, Type 1 Arginase, Arginase-1, Liver-Type Arginase
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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Arginase I, also known as ARG1, is a 34.7kD protein expressed by neutrophils and myeloid-derived suppressor cells (MDSCs). There are two isoforms that are differentiated based on their tissue distribution and subcellular localization. Arginase I converts L-arginine into L-ornithine and urea; it is the final enzyme in the urea cycle. While mostly found in the liver, it can also be expressed in cells lacking a comprehensive urea cycle. Also, it contributes to vasodilation and vascular function. Arginase I is also reported to be involved in MDSC mediated suppression of T cell proliferation. Arginase I has been implicated in hyperargininemia (decreased function of arginase I) and Q fever.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Full length recombinant protein expressed in E.coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with PerCP/Cyanine5.5 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICFC – Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.
- Excitation Laser
Blue Laser (488 nm)
AB_2910417 (BioLegend Cat. No. 369709)
AB_2910417 (BioLegend Cat. No. 369710)
- Belongs to the ureohydrolase family and has a molecular mass of 34.7 kD.
Neutrophils and myeloid-derived suppressor cells (MDSC)
- Converts L-arginine into L-ornithine and urea
- Cell Type
- Biology Area
- Cell Biology, Immunology, Neuroinflammation, Neuroscience
- Molecular Family
- Enzymes and Regulators
- Antigen References
- Munder M, et al. 2005. Blood. 105:2549-56.
- Luckner-Minden C, et al. 2010. J Leukoc Biol. 87:1125-32.
- Holowatz L, et al. 2006. Journal of Physiology. 574:573-81.
- Sin YY, et al. 2013. PLoS One. 8:11.
- Benoit M, et al. 2008. Eur J Immunol. 4:1065-70.
- Gene ID
- 383 View all products for this Gene ID
- View information about Arginase I on UniProt.org
- How stable is PerCP/Cyanine5.5 tandem as compared to PerCP alone?
PerCP/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.
|Purified anti-human Arginase I||14D2C43||ICFC|
|PE anti-human Arginase I||14D2C43||ICFC|
|APC anti-human Arginase I||14D2C43||ICFC|
|PE/Cyanine7 anti-human Arginase I||14D2C43||ICFC|
|PerCP/Cyanine5.5 anti-human Arginase 1||14D2C43||ICFC|
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