- F31-5G3 (See other available formats)
- Regulatory Status
- Other Names
- T cell immunoglobulin and mucin domain containing protein-4
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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TIM4 is a transmembrane protein known as T cell immunoglobulin and mucin domain containing protein-4. It is expressed on antigen-presenting cells and not on T cells.TIM4 binds to TIM1 to promote T cell proliferation by enhancing cell division and reducing apoptosis.TIM4 bind to phosphatidylserine through its FG-CC’ binding cleft in the N-terminal IgV domain to facilitate the clearance of apoptotic cells or bodies.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Mouse TIM4-Ig fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
(PubMed link indicates BioLegend citation)
- Rodriguez-Manzanet R, et al. 2008. J. Immunol. 180:4706
- Product Citations
AB_1227799 (BioLegend Cat. No. 129905)
AB_1227798 (BioLegend Cat. No. 129906)
- Transmembrane protein containing immunoglobulin domain and mucin-like domain
Unlike the other TIMs, TIM4 is only expressed by antigen-presenting cells, but not by T cells.
- TIM4 is expressed on antigen-presenting cells. It provides co-stimulation to promote T cell proliferation and survival and has a possible role in clearance of apoptotic cells by binding phosphatidylserine.
- Phosphatiylserine is the ligand of TIM4 and TIM4 is a ligand of TIM1
- Phosphatidylserine, TIM1
- Cell Type
- Antigen-presenting cells
- Biology Area
- Antigen References
1. Kuchroo VK, et al. 2008. Nat. Rev. Immunol. 8:577
2. Miyanishi M et al. 2007. Nature 450:435
3. Rodriguez-Manzanet R et al. 2008. J. Immunol. 180:4706
- Gene ID
- 276891 View all products for this Gene ID
- View information about Tim-4 on UniProt.org
Related Pages & Pathways
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other FormatsView All Tim-4 Reagents Request Custom Conjugation
|PE anti-mouse Tim-4||F31-5G3||FC|
|Alexa Fluor® 647 anti-mouse Tim-4||F31-5G3||FC|
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