- 16E5 (See other available formats)
- Regulatory Status
- Other Names
- Trem-l4, TREM like transcript 4, triggering receptor expressed on myeloid cells-like 4
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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Trem-like 4, a type I transmembrane protein and a member of the TREM family, consists of a single extracellular Ig-like domain of the V-type, a transmembrane domain, and a short cytoplasmic domain. Trem-like 4 is expressed on macrophages in the spleen, and dendritic cells, especially CD8+ dendritic cells. It is proposed to regulate the immune response based on its expression profile. It has been reported that B7-H3 is a receptor and that the soluble form of Treml4 has a binding affinity to late apoptotic or necrotic cells.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Extracellular domain of recombinant mouse Trem-like 4
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
IHC-F, IP, WB - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
Additional reported applications (for the relevant formats) include: immunofluorescent staining, immunoprecipitation, and Western blotting1.
- Application References
- Hemmi H, et al. 2009. J. Immunol. 182:1278. (WB)
AB_11149169 (BioLegend Cat. No. 143302)
- Type I transmembrane protein; member of the TREM family
CD8+ dendritic cells, dendritic cell subsets, macrophages in the spleen, myeloid cells
- Regulates innate immune response and homeostatis
- Associates with DAP12; binds late apoptotic cells/necrotic cells
- Cell Type
- B cells, Dendritic cells, Macrophages
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- MHC Antigens
- Antigen References
1. Ford JW and McVicar DW. 2009. Curr. Opin. Immunol. 21:38.
2. Hemmi H, et al. 2009. J. Immunol. 182:1278.
- Gene ID
- 224840 View all products for this Gene ID
- View information about Trem-like 4 on UniProt.org
|Purified anti-mouse Trem-like 4 (Treml4)||16E5||FC, IHC-F, IP, WB|
|PE anti-mouse Trem-like 4 (Treml4)||16E5||FC|
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