To drive innovation in cell signaling pathways, we offer unique antibody clones for novel phosphorylation sites and specificities. Many of our clones have been cross-platform validated for use in intracellular flow cytometry, western blotting, immunocytochemistry, immunohistochemistry and more. We test our antibodies on primary cells to ensure that our antibodies recognize endogenous protein modifications.
ZAP70 plays a critical role in T cell receptor signaling pathways including activation and cytokine production. After receptor engagement, ZAP70 undergoes multiple phosphorylation events. We offer a complete set of phosphorylation-specific ZAP70 antibodies, including a unique specificity for phosphorylated Tyr493.
Stimulated (left) or unstimulated (right) human peripheral blood lymphocytes stained with anti-ZAP70 Phospho (Tyr493) antibody.
T Cell Signaling Antibodies
LCK Phospho (Tyr505)
PLCγ1 Phospho (Tyr783)
SLP76 Phospho (Ser376)
ZAP70 Phospho (Tyr 292)
ZAP70 Phospho (Tyr319)/Syk Phospho (Tyr352)
ZAP70 Phospho (Tyr493)
Recombinant Proteins for T cell Activation
IL-2
IL-12
BTK-mediated B cell receptor signaling is required for B cell survival. Dysregulation of BTK is associated with hematological malignancies. BTK signaling relies on a number of specific-phosphorylation events. In addition to a complete set of BTK phosphorylation-specific antibodies, we offer the only antibody specific to BTK phospho Tyr223 which does not exhibit cross-reactivity to YTK. These reagents make it easier to identify novel roles for phosphorylation events in signaling pathways.
Mouse splenocytes were treated with hydrogen peroxide and stained with anti-CD19 APC and anti-BTK Phospho (Tyr223) PE antibodies (left)
or isotype control (right).
B Cell Signaling Antibodies
BTK Phospho (Tyr223)
BTK Phospho (Tyr223)/ITK Phospho (Tyr180)
BTK Phopho (Tyr551)/ITK Phospho (Tyr512)
Recombinant Proteins for B cell Activation
BAFF
CD40L
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